Understanding the human metagenome's role in metabolic diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study aims to explore the role of the human metagenome and associated metabolites in health and various metabolic diseases, particularly obesity and sarcopenia. Participants will provide fecal, salivary, urine, serum, and mucosal samples for metagenomic sequencing and metabolite analysis. The study seeks to identify differences in the metagenome and metabolome across different health states, with the potential for future personalized therapeutic applications. A cohort of healthy controls will also be included for comparison.

Why it matters

Who can join: the full rules

Inclusion Criteria (obese cohort):

* Obese (BMI\>27.5kg/m2)

Inclusion Criteria (sarcopenic cohort):

* Sarcopenic patients, defined as 1) low handgrip strength (\<26 for males; \<18kg for females), AND/OR low gait speed (\<0.8m/s) AND low muscle mass (\<7.0kg/m2 for males; \<5.7kg/m2 for females)

Inclusion Criteria (control cohort):

\- Healthy subjects without sarcopenia, and not obese (BMI\<27.5kg/m2)

Exclusion Criteria:

* No informed consent
* Presence of intestinal stoma, hence inability to collect fecal samples

Where it's running

• Sengkang General Hospital
  Singapore, Singapore Recruiting

Study contacts

• Study coordinator: Koy Min Chue
• Email: chue.koy.min@singhealth.com.sg
• Phone: 69305000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.