How nutrition and body composition relate to outcomes in people with IBD
Official title: Nutrition and Body Composition and Association With Clinical Outcomes in Inflammatory Bowel Disease
Run by Barts & The London NHS Trust · NCT06550310 · Data updated 2026-11-12
This study will see if nutrition and muscle mass affect outcomes in people with Crohn's disease or ulcerative colitis who are starting advanced medicines or having IBD-related surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 16 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Barts & The London NHS Trust Academic / other |
| Locations | 1 site (London) |
| Status | Recruiting |
| Started | October 24, 2024 |
| Main results expected | May 2028 |
| Study ends | December 2028 |
| Registry record updated | February 19, 2026 |
| Trial ID | NCT06550310 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged over 16 with Crohn's disease, ulcerative colitis, or IBD-unclassified who are about to start a new advanced medical therapy or undergo IBD-related surgery and can provide written informed consent.
✕Probably not a fit
People under 16, those unable to give consent, patients with active cancer or severe cachexia, and those with contraindicated implants like pacemakers or internal defibrillators are excluded and would not be expected to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational cohort study that measures nutritional status, nutritional biomarkers, and body composition in people with IBD at baseline before starting advanced medical therapy or undergoing IBD-related surgery and again at scheduled follow-up. The study compares detection rates of undernutrition across several screening tools, physiological measures, and assessment instruments. It also correlates radiological muscle mass measurements (including lumbar skeletal muscle index) and other body composition markers with clinical outcomes such as treatment response, complications, and hospitalisation. No experimental treatments are given and assessments are limited to procedures done as part of standard clinical care.
Why it matters
Potential benefit: If successful, the results could help identify patients at higher risk who might benefit from targeted nutritional or muscle-preserving interventions to reduce complications and improve recovery.
How similar studies have gone: Previous observational studies have linked low muscle mass and poor nutritional status to worse IBD outcomes, but standardized screening tools and radiological measures have not been widely validated in this setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with inflammatory bowel disease (Crohn's disease, ulcerative colitis or IBD-U) starting a new advanced medical therapy * Patients with inflammatory bowel disease (Crohn's disease, ulcerative colitis or IBD-U) undergoing an IBD-related surgery * Age \>16 * Patients able and willing to provide written informed consent Exclusion Criteria: * Patients below the age of 16 * Patients who cannot provide informed consent * Patients with a cardiac pacemaker or internal defibrillator * Patients with active cancer and other disorders associated with severe cachexia
Where it's running
-
Barts Health NHS Trust
London, United Kingdom Recruiting
Study contacts
- Principal investigator: Shameer Mehta, MD — Barts & The London NHS Trust
- Study coordinator: Sarah Faloon, MBChB
- Email: sarah.faloon@nhs.net
- Phone: 07713444631
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Self-management program to improve health in inflammatory bowel disease
A digital self-management program is being tested to see if it helps people with inflammatory bowel disease feel better and manage their symptoms alongside standard care.
-
Observational study comparing inflammatory markers in IBD and non-IBD participants
This study is trying to see how inflammation levels in people with Crohn's Disease and Ulcerative Colitis compare to those without these conditions when they start new treatments.
-
Evaluating robotic surgery for inflammatory bowel disease
This study is testing if robotic surgery can be a good option for adults with inflammatory bowel disease, like Crohn's or ulcerative colitis, compared to traditional surgery methods.
-
Research on gut inflammation in pediatric patients with inflammatory bowel diseases
This study is trying to learn more about gut inflammation in kids with inflammatory bowel diseases by collecting health information and samples from them and comparing it to kids who have different gut issues but no inflammation.
-
Switching to subcutaneous infliximab for IBD treatment
This study is testing if switching people with inflammatory bowel disease from an intravenous form of infliximab to a subcutaneous version, given weekly or bi-weekly, can lead to better health results.
-
Analyzing genetic factors in inflammatory bowel disease across different populations
This study is trying to find out how genes and the environment affect inflammatory bowel disease by looking at samples from people with the condition and healthy individuals.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.