Condition

Glaucoma clinical trials and research

• 100Clinical trials
• 257NIH research projects
• 1New in 30 days
• 28Countries

Newest Glaucoma clinical trials

All recruiting trials (100)

• Balance training for people with glaucoma

  A randomized study tests whether a structured eight-week balance program helps adults with glaucoma improve balance, reduce fall risk, and lessen fear of falling.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Küçükçekmece, Istanbul · NCT07910955

• Eye drops Rhopressa vs Timolol to protect nerve cells in glaucoma

  In adults with open-angle glaucoma, this study tests whether Rhopressa helps preserve retinal nerve cells better than Timolol while both lower eye pressure.

  Recruiting Phase 4 Indiana University · Bloomington, Indiana · NCT07847073

• Comparison of FT-1000 non-contact tonometry with Goldmann applanation tonometry in glaucoma patients

  This study tests whether the FT-1000 non-contact tonometer gives measurements that agree with the Goldmann applanation tonometer in adults with glaucoma.

  Recruiting Tomey Corporation · Jacksonville, Florida · NCT07804277

• Removing the ripcord from a glaucoma drainage device after 3 months

  This study tests whether removing the ripcord from an implanted glaucoma drainage device changes eye pressure for adults with open-angle glaucoma.

  Recruiting Duke University · Durham, North Carolina · NCT07803536

• Glaucoma and Brain Changes: How Brain Structure and Size See What Glaucoma Is Doing

  This study tests whether glaucoma is linked to broader brain changes by comparing brain MRI and eye health over time in people with glaucoma and matched controls.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT07802769

• Long-Term Results After Ab-interno Trabeculotomy for Glaucoma

  This study tests whether ab-interno trabeculotomy with the Trabectome can provide sustained intraocular pressure reduction in glaucoma patients who had the procedure between 2019 and 2021.

  Recruiting Wuerzburg University Hospital · Würzburg, Bavaria · NCT07780916

• Cross-modal cerebellar stimulation to improve balance and vision in glaucoma

  In older adults with glaucoma, this study tests whether different cerebellar transcranial electrical stimulation methods can improve balance and visual-cognitive function.

  Recruiting The Hong Kong Polytechnic University · Kowloon, Hong Kong · NCT07771699

• ASP2767 safety and potential nerve-protection gene therapy for open-angle glaucoma

  This study tests the safety and tolerability of ASP2767 gene therapy in people with open-angle glaucoma to see if it can help protect optic nerve and vision.

  Recruiting Phase 1/2 Astellas Pharma Inc · Boston, Massachusetts · NCT07770685

• AI-assisted detection of glaucoma-related lesions in retinal photos

  A device-powered AI system is being tested to see if it can automatically identify glaucoma-related lesions in retinal photos from adults.

  Recruiting Democritus University of Thrace · Alexandroupoli · NCT07758569

• Innovative Tube Trabeculectomy for Advanced and Refractory Glaucoma

  A randomized trial tests a new surgical method called ITT against standard trabeculectomy to see if it better lowers eye pressure with fewer medications and complications in adults with advanced or treatment-resistant glaucoma.

  Recruiting Benha University · Banhā · NCT07755761

• Can personality traits influence eye side effects from glaucoma meds?

  This study tests whether personality traits are linked to how often or how severely people experience eye side effects from glaucoma medications.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT07739784

• World Sight Foundation Field Machine pilot in glaucoma care

  This pilot tests a new field machine to see if it can help identify moderate to severe glaucoma in patients at a eye clinic, compared with the standard Humphrey Visual Field test.

  Recruiting Buckinghamshire Healthcare NHS Trust · Aylesbury · NCT07674069

• Imaging the effect of Netarsudil on the eye’s drainage system in glaucoma and ocular hypertension

  This study tests whether netarsudil eye drops change the trabecular meshwork’s structure compared with placebo in adults with ocular hypertension or open-angle glaucoma.

  Recruiting Phase 4 Indiana University · Bloomington, Indiana · NCT07588152

• Choroid and retina imaging in angle‑closure versus open‑angle glaucoma using OCT and OCTA

  This project will use OCT and OCTA eye scans to see if choroidal and retinal features differ between people with primary angle‑closure disease, primary open‑angle glaucoma, and healthy volunteers.

  Recruiting Zhongshan Ophthalmic Center, Sun Yat-sen University · Guangzhou, Guangdong · NCT07580014

• Hyperspectral imaging to map retinal and optic nerve structures

  This study will test whether hyperspectral retinal imaging can detect disease-related features in adults with diabetic retinopathy, glaucoma, age-related macular degeneration, and in healthy volunteers.

  Recruiting Center for Eye Research Australia · Melbourne, Victoria · NCT07555574

• Releasable intraluminal suture to reduce hypotony after Preserflo glaucoma surgery

  This trial tests a releasable stitch technique to lower the risk of hypotony after glaucoma surgery with the Preserflo device in adults with certain types of glaucoma.

  Recruiting Hôpital Privé de la Baie · Avranches · NCT07531199

• Quality of life for people with glaucoma

  This project asks adults with glaucoma to complete vision-related questionnaires before and 3–6 months after starting treatment or having surgery to see if their scores change.

  Recruiting University of Iowa · Iowa City, Iowa · NCT07510087

• Second-generation travoprost intracameral implant versus timolol drops for open-angle glaucoma

  This will test whether a small travoprost implant placed inside the eye can lower eye pressure as well as twice-daily timolol drops in people with open-angle glaucoma or ocular hypertension.

  Recruiting Phase 3 Glaukos Corporation · Dothan, Alabama · NCT07495852

• Rocklatan added after DSLT for open-angle glaucoma

  This trial tests whether adding Rocklatan to latanoprost after a laser treatment helps lower eye pressure more than latanoprost alone in people with mild to moderate open-angle glaucoma.

  Recruiting Phase 4 Eye Centers of Southeast Texas · Beaumont, Texas · NCT07465913

• Hydrus stent long-term follow-up after eight years

  This follow-up will see if the Hydrus microstent continues to lower eye pressure and remains safe in people with glaucoma who had the implant at least eight years ago.

  Recruiting Johannes Gutenberg University Mainz · Mainz, Rhineland-Palatinate · NCT07460791

• Modified trabeculectomy after failed combined phaco with GATT

  This trial tries a modified trabeculectomy operation to lower eye pressure in people whose cataract surgery combined with GATT or phacogoniopuncture did not control their glaucoma.

  Recruiting Assiut University · Asyut · NCT07455786

• Eye pressure swings after Direct Selective Laser Trabeculoplasty (DSLT)

  This will see if Direct Selective Laser Trabeculoplasty (DSLT) reduces daytime eye pressure swings in adults with primary open-angle glaucoma who are on 0–3 eye pressure medicines.

  Recruiting Ophthalmology Associates, Fort Worth · Fort Worth, Texas · NCT07428668

• Optic Nerve Strain in Non-glaucoma Eyes

  This study tests how optic nerve strain responds to lowered eye pressure in people without glaucoma to compare with those who have glaucoma.

  Recruiting Early Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT07425535

• Measuring eye pressure and fluid outflow during cataract or glaucoma surgery

  This will test whether measuring eye pressure and fluid outflow during cataract or glaucoma surgery with a disposable sensor can help predict and improve recovery for adults having these operations.

  Recruiting The New York Eye & Ear Infirmary · New York, New York · NCT07425496

• Biofeedback training to improve vision in glaucoma

  This study will test whether short sessions of visual biofeedback training can help people with glaucoma improve fixation stability, retinal sensitivity, and everyday vision.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07409077

• How glaucoma-related changes in light sensing affect sleep, mood, alertness, and thinking

  For adults 45–75 with glaucoma, this study will test whether reduced light sensitivity is linked to worse sleep, mood, alertness, and thinking, and whether safe full‑spectrum indoor light can help.

  Recruiting National University of Singapore · Singapore and 1 other locations · NCT07364929

• iStent with cataract surgery to lower eye pressure in open-angle glaucoma

  This trial will see if placing an iStent during cataract surgery helps lower eye pressure in adults with open-angle glaucoma.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07354009

• Brain stimulation to improve orientation and mobility in adults with vision impairment

  This pilot test checks if a non-invasive brain stimulation method can help people with constricted visual fields move around more easily using a cane and other cues.

  Recruiting University of Waterloo · Waterloo, Ontario · NCT07341763

• BrudyGlauco (DHA and citicoline) for people with glaucoma

  This trial will test whether taking BrudyGlauco (DHA plus citicoline) for 12 months helps preserve visual field in adults aged 50–75 with glaucoma.

  Recruiting Institut Catala de Retina · Barcelona, Barcelona and 1 other locations · NCT07322965

• Automated applanation tonometry to measure eye pressure

  We will test two new automated, portable ways to measure eye pressure in adults with glaucoma or suspected glaucoma and see how they compare to standard methods.

  Recruiting Duke University · Durham, North Carolina · NCT07298356

• AI-assisted glaucoma screening in Singapore's diabetic eye program

  It will test whether an AI algorithm can detect glaucoma from color fundus photos in adults with diabetes attending Singapore's diabetic eye screening program.

  Recruiting Singapore Eye Research Institute · Singapore, Singapore · NCT07243665

• Bimatoprost implant with SpyGlass intraocular lens vs timolol drops for cataract patients with glaucoma

  This study tests whether placing a bimatoprost implant together with a SpyGlass intraocular lens during cataract surgery controls eye pressure better than daily timolol drops in people with mild to moderate open‑angle glaucoma or ocular hypertension.

  Recruiting Phase 3 SpyGlass Pharma, Inc. · San Antonio, Texas · NCT07218796

• Combining a bimatoprost eye implant with the SpyGlass intraocular lens versus timolol eye drops for people having cataract removal

  This study will test whether placing a small bimatoprost implant with the SpyGlass intraocular lens at the time of cataract surgery better controls eye pressure than using timolol eye drops in people with mild to moderate open-angle glaucoma or ocular hypertension.

  Recruiting Phase 3 SpyGlass Pharma, Inc. · Houston, Texas · NCT07218783

• Eye-surface inflammation after replacing nightly preserved glaucoma drops with a Durysta implant

  We will try a single Durysta intracameral implant to see if cutting back nightly preserved glaucoma drops reduces eye-surface inflammation in people with open-angle glaucoma or ocular hypertension who are pseudophakic and have signs of surface damage.

  Recruiting Phase 4 University of Miami · Miami, Florida · NCT07217678

• Brimonidine 0.025% to reduce redness from netarsudil/latanoprost

  This tests whether adding brimonidine tartrate 0.025% eye drops can reduce conjunctival redness in adults with glaucoma or ocular hypertension who are using netarsudil 0.02%/latanoprost 0.005%.

  Recruiting Phase 4 Insight Eyecare Specialties, Inc. dba Vision Source Eyecare, · Kansas City, Missouri · NCT07209410

• Baduanjin exercise for glaucoma in older adults

  This trial will try Baduanjin, a gentle qigong exercise, with older adults who have high-tension primary open-angle glaucoma or ocular hypertension to see if daily practice helps their eye pressure or symptoms.

  Recruiting Cairo University · Giza, Dokki · NCT07163676

• OCT data collection from healthy and diseased eyes (A10900)

  This project will collect Optical Coherence Tomography (OCT) scans from adults 22 and older who have retinal disease, glaucoma, corneal conditions, or are healthy to build a reference dataset for A10900.

  Recruiting at 3 sites Optos, PLC · Anaheim, California and 3 other locations · NCT07149740

• Repeated transcranial alternating current stimulation to improve vision in glaucoma

  This trial will try repeated transcranial alternating current stimulation to see if it can reactivate damaged retinal ganglion cells and improve visual function in people with glaucoma.

  Recruiting National Taiwan University Hospital · Taipei, Hawaii · NCT07145073

• My Eyes, My Light — community eye screening in Char Fasson

  This project tests whether a community-based screening program can find treatable eye problems in people aged 35 and older who live in Char Fasson, Bangladesh.

  Recruiting Data Yakka, Inc. · Char Fasson, Bhola · NCT07135570

• Limbal function and tear protein changes in glaucoma

  This study tests whether glaucoma and long-term glaucoma medicines change limbal stem cell–related corneal epithelial thickness and tear proteins in people with glaucoma, ocular hypertension, or healthy adults.

  Recruiting National Taiwan University Hospital · Hsinchu · NCT07119580

• Direct selective laser trabeculoplasty to lower eye pressure in untreated open-angle glaucoma

  This study will try direct selective laser trabeculoplasty (DSLT) to lower eye pressure by more than 20% without glaucoma medications over six months in adults newly diagnosed with open-angle glaucoma or ocular hypertension.

  Recruiting Shafer Vision Institute · Plymouth Meeting, Pennsylvania · NCT07076303

• Second-generation travoprost intracameral implant for open-angle glaucoma and ocular hypertension

  This trial will test whether a second-generation travoprost implant placed inside the eye lowers eye pressure better than timolol eye drops in people with open-angle glaucoma or ocular hypertension.

  Recruiting at 3 sites Phase 2 Glaukos Corporation · Grand Junction, Colorado and 2 other locations · NCT07075718

• Sustained-release TimoD (timolol) implant placed during cataract surgery for glaucoma or ocular hypertension

  This trial tests whether a small TimoD timolol implant placed during cataract surgery is safe and well tolerated in people with glaucoma or ocular hypertension.

  Recruiting Phase 1/2 EyeD Pharma · Panama City · NCT07036510

• Vision screening in general practice to catch preventable sight loss in people over 70

  This project will test a GP-based vision-screening program for people aged 70 and older with at least one chronic condition to find sight problems early.

  Recruiting at 2 sites University of Copenhagen · Copenhagen, Capital Region and 1 other locations · NCT07015034

• MINIject S+ for Open Angle Glaucoma in Adults

  This study tests MINIject S+ implants in adults with open angle glaucoma to see if it works well and is safe using different insertion tools, with later expansion to more patients undergoing combined glaucoma and cataract surgery.

  Recruiting at 5 sites iSTAR Medical · Santa Rosa de Copán and 4 other locations · NCT07009236

• Measuring corneal stiffness in glaucoma with Brillouin microscopy

  We will use Brillouin microscopy to see if corneal stiffness differs between adults with normal-tension glaucoma, high-tension glaucoma, and people without glaucoma, and whether stiffness changes after common IOP-lowering eye drops.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT06993597

• Comparing NAD precursors to improve vision in glaucoma patients

  This study is testing whether different oral supplements can help improve vision in adults with glaucoma.

  Recruiting Phase 2 The University of Hong Kong · Wong Chuk Hang · NCT06991712

• Assessing the effects of repeated laser treatment for glaucoma management

  This study tests if giving two laser treatments for glaucoma can help keep eye pressure low without needing daily eye drops, compared to just one treatment.

  Recruiting Twin Cities Eye Consultants · Coon Rapids, Minnesota · NCT06963684

• Improving follow-up after an eye screening referral

  This trial tries text message or health worker reminders to help people referred after an eye screening get to their hospital appointment within 21 days.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06943599

• Michigan telemedicine screening for glaucoma and other sight‑threatening eye problems

  This program tests whether a technology-enhanced telemedicine screening finds glaucoma, diabetic eye disease, and visually significant cataracts more often than a standard optometric exam for patients at a community health center.

  Recruiting University of Michigan · Flint, Michigan · NCT06934577

• Combined glaucoma screening during diabetic eye exams

  This program tests whether adding an AI review of retinal photos, a quick eye pressure check, and a virtual-reality side-vision test to routine diabetic eye screening helps find glaucoma earlier in people with diabetes.

  Recruiting at 6 sites Massachusetts Eye and Ear Infirmary · Boston, Massachusetts and 6 other locations · NCT06882356

• Glaucoma screening to improve health of at-risk Californians

  This project will try mobile telemedicine glaucoma screening using OCT, fundus photos, and tonometry for older Black and Hispanic adults and people with diabetes seen at community clinics to see if it finds more undiagnosed glaucoma than giving education or delaying screening.

  Recruiting at 2 sites University of California, San Francisco · Fremont, California and 2 other locations · NCT06854198

• Comparing two microinvasive glaucoma surgeries with cataract surgery

  This study tests which of two new glaucoma surgeries, MINIject or Hydrus, works better when done with cataract surgery for people with chronic glaucoma.

  Recruiting Medical University of Graz · Graz, Styria · NCT06844292

• Auto-aligning handheld OCT for adult and pediatric retinal imaging

  We will test a new handheld OCT device that automatically aligns to capture retinal images in healthy adults, adult eye patients, and children.

  Recruiting Duke University · Durham, North Carolina · NCT06841575

• Evaluating the effectiveness of laser treatment for glaucoma patients

  This study tests whether a new laser treatment can help lower eye pressure in people with open-angle glaucoma over the course of a year.

  Recruiting Clínica Rementería · Madrid, Madrid · NCT06808633

• Investigating oral semaglutide for treating open-angle glaucoma

  This study is testing if a daily pill called semaglutide can help improve vision in people with open-angle glaucoma.

  Recruiting Phase 4 Glostrup University Hospital, Copenhagen · Glostrup Municipality · NCT06792422

• ELIOS laser used during cataract surgery to treat glaucoma

  This trial will test whether using the ELIOS excimer laser at the time of cataract surgery lowers eye pressure in adults with early to moderate open-angle glaucoma.

  Recruiting Hôpital Privé de la Baie · Avranches · NCT06760169

• Cataract surgery using low pressure techniques for glaucoma patients

  This study is testing a new cataract surgery method using lower pressure to see if it helps glaucoma patients have safer and better outcomes.

  Recruiting Visionair Oogzorg · Geel · NCT06712758

• Evaluating the long-term safety and effectiveness of a modified silicone tube for glaucoma treatment

  This study is testing a new silicone tube to see if it safely helps people with glaucoma manage their eye pressure and maintain good vision over the long term.

  Recruiting Davinci LTD · Tbilisi · NCT06691555

• Electrical stimulation to improve vision in glaucoma

  This trial will test whether a noninvasive transorbital alternating current stimulation device (EYETRONIC rtACS) can improve vision in adults with moderate open-angle glaucoma.

  Recruiting Stanford University · Palo Alto, California · NCT06685211

• Electrical stimulation treatment for visual field defects in glaucoma patients

  This study is testing if a new electrical stimulation treatment can help people with glaucoma keep their vision from getting worse while they continue using their regular eye drops.

  Recruiting Okuvision GmbH · Mainz · NCT06682962

• AI-based glaucoma and eye disease screening at federally qualified health centers

  This project will test whether an AI-assisted eye screening program at federally qualified health centers can find glaucoma and other eye problems (like diabetic retinopathy and cataracts) and whether people follow up with an eye doctor.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06629649

• Observing changes in the eye's drainage angle after surgery

  This study looks at how different eye surgeries can help people with glaucoma by checking the changes in their eye drainage angle after the procedures.

  Recruiting Zhongshan Ophthalmic Center, Sun Yat-sen University · Guangzhou, Guangdong · NCT06492538

• Comparing Hydrus Microstent and Goniotomy for Glaucoma Treatment

  This study is testing whether the Hydrus Microstent works better than goniotomy for lowering eye pressure in people with mild to moderate glaucoma who are also having cataract surgery.

  Recruiting Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT06289491

• Examining blood vessel changes in advanced glaucoma patients

  This study is testing how changes in blood vessels around the optic nerve affect vision loss in people with advanced glaucoma over three years.

  Recruiting Nantes University Hospital · Nantes, Nantes and 1 other locations · NCT06274593

• Comparing cytokine levels in eye fluids before and after a specific glaucoma treatment

  This study is testing how a glaucoma treatment called Ultrasound Cyclo Plasty affects certain proteins in the eye fluids of patients to see if it helps manage their condition better.

  Recruiting Zhongshan Ophthalmic Center, Sun Yat-sen University · Guangzhou, Guangdong · NCT06243497

• Evaluating visual field detection methods in early glaucoma patients

  This study is testing which of three different methods works best to find vision problems in people with early glaucoma.

  Recruiting at 2 sites Fondazione G.B. Bietti, IRCCS · Rome and 1 other locations · NCT06227611

• Comparing two OCT imaging systems for pediatric retina evaluation

  This study is testing two different eye imaging systems to see which one works better for looking at the retinas of children.

  Recruiting Duke University · Durham, North Carolina · NCT06139523

• Using hyperbaric oxygen therapy to treat optic neuropathies

  This study is testing if hyperbaric oxygen therapy can help improve vision and eye health for adults with optic neuropathy.

  Recruiting Stanford University · Palo Alto, California · NCT06128720

• Community-based treatment for glaucoma

  This study tests if community support and education can encourage Black or African American people who have been screened for glaucoma to seek eye care and prevent blindness.

  Recruiting University of Michigan · Ann Arbor, Michigan and 1 other locations · NCT06124521

• Treatment for mild to moderate primary open-angle glaucoma using the iStent Infinite device

  This study is testing a new device called the iStent Infinite to see if it can help adults with mild to moderate glaucoma who haven't had success with other treatments.

  Recruiting Glaukos Corporation · Cincinnati, Ohio · NCT06057051

• Improving mobility in glaucoma patients using video games and exercise

  This study is testing if playing action video games combined with exercise can help glaucoma patients improve their mobility and feel less afraid of falling.

  Recruiting The Hong Kong Polytechnic University · Hong Kong, Hong Kong · NCT06000865

• Home IOP telemonitoring with smartphone support for open-angle glaucoma

  This trial tests whether home intraocular pressure monitoring plus a smartphone-based management plan helps people with newly diagnosed open-angle glaucoma control eye pressure better than a smartphone-based plan alone.

  Recruiting The University of Hong Kong · Wong Chuk Hang · NCT05940623

• Comparing two methods of glaucoma drainage device implantation

  This study is testing whether placing a glaucoma drainage device in the front part of the eye or in a different spot helps people with glaucoma manage their eye pressure and cell health better over time.

  Recruiting at 8 sites University of Pennsylvania · San Francisco, California and 7 other locations · NCT05924477

• Improving vision in glaucoma patients using electrical stimulation and learning techniques

  This study is testing if combining brain stimulation with special learning techniques can help improve vision in people with glaucoma.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT05874258

• Evaluating visual field changes in glaucoma patients

  This study is trying to see how different ways of measuring vision changes can help track the progression of glaucoma in patients over three years.

  Recruiting at 2 sites Centervue SpA · Milan, Milano and 1 other locations · NCT05801471

• Using blood flow imaging to assess glaucoma

  This study is testing whether new imaging tools can help doctors see differences in blood flow in the eyes of people with glaucoma compared to healthy individuals.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT05726058

• Lignocaine microneedle patch versus 5% EMLA patch for numbing the skin before blood draws in adults

  We will try a dissolvable maltose microneedle patch that delivers lignocaine to numb the skin before blood draws in adults having eye surgery and compare it with the standard 5% EMLA patch.

  Recruiting Phase 1/2 Universiti Kebangsaan Malaysia Medical Centre · Kuala Lumpur, Kuala Lumpur · NCT05694858

• Comparing eye pressure measurements using the TonoVera device and other tonometers

  This study is testing how well the TonoVera device measures eye pressure compared to other common devices to help people with glaucoma.

  Recruiting State University of New York at Buffalo · Buffalo, New York · NCT05523622

• Metformin to protect the optic nerve in glaucoma

  This trial will test whether taking metformin twice daily helps slow optic nerve thinning and vision loss in adults with primary open‑angle glaucoma who are still progressing despite controlled eye pressure.

  Recruiting Phase 2 The University of Hong Kong · Wong Chuk Hang · NCT05426044

• Understanding retinal blood flow in glaucoma patients

  This study is testing if measuring blood flow in the retina can help find early signs of glaucoma in patients so that better treatments can be developed.

  Recruiting at 4 sites Phase 4 University of Maryland, Baltimore · Baltimore, Maryland and 3 other locations · NCT05344274

• Micro-invasive surgery for glaucoma treatment

  This study is testing a new micro-surgery for glaucoma to see if it works better and has fewer problems than traditional surgeries for patients needing treatment.

  Recruiting Oslo University Hospital · Oslo · NCT05340647

• Nicotinamide treatment for glaucoma patients

  This study is testing if Nicotinamide can help people with open-angle glaucoma keep their vision from getting worse over two years.

  Recruiting at 2 sites Umeå University · Stockholm and 1 other locations · NCT05275738

• Assessing the Glycocalyx in Patients with Primary Open-angle Glaucoma

  This study is testing a special imaging technique to see if the tiny blood vessels in people with primary open-angle glaucoma are working properly compared to those without eye problems.

  Recruiting Fondation Ophtalmologique Adolphe de Rothschild · Paris · NCT05264818

• Topical insulin treatment for glaucoma

  This study is testing if applying insulin directly to the eye can be a safe treatment for people with glaucoma and other optic nerve problems.

  Recruiting Phase 1 Stanford University · Palo Alto, California · NCT05206877

• Comparing the effects of two types of eye drops on eye health

  This study tests whether eye drops with preservatives or preservative-free eye drops are better for eye health in people with glaucoma or high eye pressure.

  Recruiting Phase 4 Copenhagen University Hospital, Rigshospitalet · Glostrup Municipality, Danmark and 1 other locations · NCT04957329

• Relieving eye-surface discomfort in glaucoma patients using multiple eye drops

  This will try Xiidra eye drops to relieve ocular surface discomfort in people with glaucoma who are using one or more topical glaucoma medications.

  Recruiting University of California, Los Angeles · Fountain Valley, California · NCT04354545

• Investigating inflammatory markers in glaucoma after corneal transplantation

  This study is trying to find out if certain markers in the tears and eye fluid of people who have had corneal transplants can help spot early signs of glaucoma.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT04339907

• Using laser treatment to manage glaucoma in patients receiving a Boston keratoprosthesis

  This study is testing a laser treatment to see if it can help manage glaucoma in patients who have received an artificial cornea to improve their vision.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT04232982

• Advanced imaging techniques for eye conditions

  This study is testing new advanced imaging techniques to see if they can help doctors better understand and diagnose eye diseases like retinitis pigmentosa and maculopathy.

  Recruiting Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts · Paris · NCT04129021

• Continuous intraocular pressure monitoring with a sensing contact lens versus standard tonometry

  This trial tests a smart contact lens that continuously measures eye pressure and compares its readings to standard tonometry in people with glaucoma or ocular hypertension.

  Recruiting Sensimed AG · Lausanne, Canton of Vaud · NCT04024293

• Pilocarpine after cataract and Kahook goniotomy

  This trial will test whether giving pilocarpine after combined cataract and Kahook Dual Blade surgery helps lower eye pressure and reduce the need for glaucoma medicines in people with open-angle glaucoma or ocular hypertension.

  Recruiting at 2 sites Phase 3 Montefiore Medical Center · The Bronx, New York and 1 other locations · NCT03933631

• Community-based eye screening program to prevent blindness

  This study is testing whether a community eye screening program in Nepal can help prevent avoidable blindness by catching eye problems early.

  Recruiting University of California, San Francisco · San Francisco, California · NCT03752840

• Investigating genetic factors in different types of glaucoma

  This study is trying to find out if certain genes are linked to different types of glaucoma by looking at blood samples from patients with these conditions and healthy people.

  Recruiting Medical University of Vienna · Vienna · NCT03423758

• Using stem cells to treat retinal and optic nerve damage

  This study is testing if using stem cells from your own bone marrow can help improve vision in people with serious eye damage from conditions like age-related macular degeneration and optic nerve problems.

  Recruiting at 4 sites MD Stem Cells · Westport, Connecticut and 3 other locations · NCT03011541

• Evaluation of glaucoma patient follow-up and treatment quality

  This study looks at how well glaucoma patients are being followed up and treated at a university hospital to see if their care can be improved.

  Recruiting Technische Universität Dresden · Dresden, Saxony · NCT02959242

• Timing of glaucoma drainage device placement with Boston keratoprosthesis

  This study is trying to find out the best time to place a glaucoma drainage device for patients getting a Boston keratoprosthesis to help prevent vision loss from glaucoma.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT02084745

• Evaluating pupil response to light in patients with retinal conditions

  This study is testing a new way to check vision by measuring how pupils respond to light in people with retinal conditions like glaucoma to see if it’s better than current methods.

  Recruiting Sheba Medical Center · Tel HaShomer · NCT02014389

• Improving imaging techniques for glaucoma detection

  This study is testing new imaging techniques to see if they can help doctors better detect and monitor glaucoma, especially in patients who have normal eye pressure.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT01957267

• Evaluating new technologies for diagnosing glaucoma and macular diseases

  This study is testing new imaging technologies to see if they can better diagnose and monitor eye diseases like glaucoma and macular degeneration, while also looking for eye signs that might indicate Alzheimer's Disease.

  Recruiting Wills Eye · Philadelphia, Pennsylvania · NCT00286637

NIH-funded research (newest 40 of 257)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• IOP and CSF Pressure in Glaucoma Risk

  This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11644421

• Comparing tube positions in glaucoma implants to protect corneal cells

  This trial compares two tube placements for glaucoma drainage implants to see which better protects corneal cells and controls eye pressure in people with uncontrolled glaucoma.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11520347

• Automated topographic test for glaucoma detection and progression

  A new automated method uses topographic structure-function mapping to help diagnose glaucoma earlier and track its progression in patients.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11516608

• Using AI on eye scans and genes to predict glaucoma risk

  This project uses artificial intelligence on eye scans, vision tests, and genetic information to find people most likely to develop or have worsening glaucoma.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11469603

• AI-based glaucoma screening in community health centers

  A new, easy-to-use AI screening approach will be tested in federally funded health centers to help identify people at risk for glaucoma, especially in communities with higher risk.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11454104

• Understanding how glaucoma genes control eye cell function

  A long-term research project will study how genetic factors affect eye cells in adults with glaucoma to uncover new ideas for protecting vision.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11450761

• Targeted dendrimer-n-acetylcysteine for protecting vision in glaucoma

  A new patient-friendly treatment aims to deliver a neuroprotective drug directly to retinal cells to help people with glaucoma preserve their sight.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11450479

• Apelin signaling role in Schlemm's canal development and congenital glaucoma

  Researchers are studying how a chemical signal called Apelin helps develop a key eye drainage channel to prevent high eye pressure and congenital glaucoma.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11450077

• WDR36 Variants and p53 in Glaucoma

  This grant studies how genetic changes in WDR36 and the p53 pathway contribute to glaucoma and whether gene-based approaches could protect eye cells.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11449005

• AI-powered eye scans to detect glaucoma earlier and more accurately

  A new project uses advanced eye imaging and artificial intelligence to measure a tiny retina layer more precisely, helping detect glaucoma earlier for patients.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11448822

• Purified myocilin and glaucoma: understanding a protein misfolding disease

  A research project at a major university is exploring how a protein called myocilin misfolds and contributes to glaucoma, with the goal of informing future treatments.

  NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11448745

• Early detection and noninvasive monitoring of glaucoma-related nerve changes

  Aims to identify and track early molecular changes in retinal nerve cells to help detect glaucoma sooner.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11446671

• Hyalocytes and glaucoma: how eye macrophages respond to pressure and help or harm vision

  This project looks at hyalocytes, special immune cells in the eye, to understand how they behave in glaucoma and what that means for people who may lose vision.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11441351

• Pulsatility in the Retina and Blood Flow in Glaucoma

  A project to study how pulsation and blood flow in the eye relate to glaucoma, using patient eyes and clinically available imaging tools.

  NIH research Legacy Emanuel Hospital and Health Center · Portland, UNITED STATES · NIH-11432658

• Epigenetic control of optic nerve head cells in glaucoma

  This grant aims to understand how age and eye pressure change specific brain-like cells at the optic nerve head to influence glaucoma progression and retinal cell survival.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11430238

• Macrophages and eye pressure: clearing a path to glaucoma prevention

  A Duke University team is studying how specific eye immune cells called macrophages help keep pressure in your eye stable to prevent glaucoma.

  NIH research Duke University · Durham, United States · NIH-11427533

• Artificial Intelligence–Assisted Teleophthalmology for Glaucoma Screening

  A large trial tests an AI-powered teleophthalmology platform to screen for glaucoma and help guide care, with patients at risk of vision loss in mind.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11423232

• Improving glaucoma implant surfaces to prevent scarring

  Trying new glaucoma implant surface designs to lower scarring and complications after surgery for people with advanced glaucoma.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11421501

• Glaucoma risk prediction with advanced genetics and machine learning

  Aiming to better predict who will develop glaucoma and how it might progress, using genetic information and smart computer methods so doctors can tailor care.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11420833

• Population-wide deep learning glaucoma screening Models

  Aims to create AI eye-screening tools that work well for diverse populations so people can get easy glaucoma checks from primary care or pharmacies.

  NIH research Schepens Eye Research Institute · Boston, United States · NIH-11419231

• Genetic profiling of childhood glaucoma in India

  A study will analyze the genetic makeup of children with glaucoma in India to better understand the causes and improve future diagnoses.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11419200

• AI-powered glaucoma screening tool using fundus photos

  A machine-learning model analyzes fundus photos to estimate glaucoma-related nerve damage, aiming to make screening cheaper and easier for adults.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11419186

• Advancing Eye Disease Care with AI: A Tool to Detect Glaucoma Earlier

  A university research team is building an AI-powered tool to help doctors detect glaucoma earlier and predict vision loss using multiple kinds of eye data.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11419179

• Longitudinal eye changes in naturally occurring glaucoma in nonhuman primates

  A study in rhesus macaques with naturally occurring glaucoma will track eye changes over time to better understand how glaucoma develops in a way that reflects human disease.

  NIH research Wills Eye Health System · Philadelphia, United States · NIH-11418950

• Monitoring advanced glaucoma with AI to track central vision

  A study at UC San Diego uses computer-based AI tools to watch how severe glaucoma changes the central vision and macula over time so doctors can tailor care.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11418939

• Understanding how myopia and glaucoma are connected through eye mechanics

  This study looks at how eye growth in myopia may influence glaucoma risk and what markers could identify it early.

  NIH research State College of Optometry · New York, United States · NIH-11418938

• Role of cellular memory in glaucoma

  Scientists are studying how eye cells in glaucoma “remember” mechanical stress and stay diseased even after conditions improve, with the goal of finding ways to prevent ongoing eye pressure damage.

  NIH research Upstate Medical University · Syracuse, United States · NIH-11418926

• Glypicans and eye drainage: a new path to lowering eye pressure

  This grant studies how certain surface molecules called glypicans influence eye fluid drainage and pressure in glaucoma, with the goal of finding safer ways to lower pressure.

  NIH research Duke University · Durham, United States · NIH-11418904

• Novel glaucoma diagnostics using 3-D imaging and AI

  A research project aims to improve early detection and tracking of glaucoma by combining 3-D eye imaging with artificial intelligence.

  NIH research Wills Eye Health System · Philadelphia, United States · NIH-11418896

• Microglia-driven inflammation in glaucoma and its impact on retinal cells

  A study in mice looks at how immune cells in the eye’s retina (microglia) drive damage in glaucoma and tests if blocking a specific receptor can protect retinal cells.

  NIH research Schepens Eye Research Institute · Boston, United States · NIH-11418878

• Cholinergic Dysfunction in Glaucoma

  This NIH grant funds research to understand how brain cholinergic signaling relates to glaucoma in adults and animal models, aiming to uncover new pathways beyond eye pressure to explain vision loss.

  NIH research Stanford University · Stanford, United States · NIH-11418841

• Understanding how glaucoma affects daily life and quality of life

  This project looks at how different patterns of vision loss from glaucoma influence everyday activities and overall well-being, and aims to translate that into practical guidance for patients and clinicians.

  NIH research Legacy Emanuel Hospital and Health Center · Portland, UNITED STATES · NIH-11418060

• Gene therapy to normalize eye pressure in juvenile glaucoma

  A first-in-class gene therapy using a safe viral vector is being explored to normalize eye pressure in children and adults with juvenile open-angle glaucoma.

  NIH research Diorasis Therapeutics Corporation · Watertown, UNITED STATES · NIH-11409527

• Imaging eye blood flow to guide tiny glaucoma surgeries

  A new imaging approach helps surgeons see eye blood flow during minimally invasive glaucoma surgery to improve outcomes for adults with glaucoma.

  NIH research Vasoptic Medical, INC. · Baltimore, United States · NIH-11407312

• VR headset tests for glaucoma patients who struggle with traditional vision tests

  A patient-friendly VR headset test is being developed to reliably measure glaucoma progression in people who have trouble with standard eye tests.

  NIH research Vivid Vision, INC. · San Francisco, United States · NIH-11406843

• One-Time CRISPR Therapy to Improve Eye Drainage in Glaucoma

  A one-time genetic therapy delivered into the eye aims to lower pressure in people with glaucoma by relaxing the eye’s drainage tissue and improving fluid outflow, potentially reducing the need for daily eye drops.

  NIH research Outflowgen LLC · Portland, United States · NIH-11405130

• Diagnostic Innovations in Glaucoma for High Myopia

  A study to improve early detection of open-angle glaucoma in people with high myopia using advanced eye imaging.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11397407

• Iris biomechanics and sex differences in primary angle-closure glaucoma

  This project looks at how the eye’s iris biomechanics and sex differences may contribute to angle-closure glaucoma and how this could affect risk and progression.

  NIH research University of South Florida · Tampa, United States · NIH-11394784

• Functionalized SARM1 nanobodies to protect vision in glaucoma

  A research project aims to create specially engineered nanobodies that inhibit SARM1 to protect retinal cells and preserve vision in glaucoma.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11394606

• ER stress–modulating chemicals to protect vision in glaucoma

  A Stanford team is testing small molecules that reduce stress in retinal cells to prevent vision loss from glaucoma.

  NIH research Stanford University · Stanford, United States · NIH-11394364

Related topics

Quick answers

How many Glaucoma clinical trials are recruiting right now?

100, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 28 countries. The most sites are in United States (44 trials), Canada (7 trials), France (6 trials), Hong Kong (6 trials), China (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 8, Phase 3: 4, Phase 2: 3, Phase 1/2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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