Condition
Diabetic Retinopathy clinical trials and research
As of November 12, 2026, Find a Trial lists 46 Diabetic Retinopathy clinical trials that are recruiting, at sites in 27 countries (most in United States (19), China (5), United Kingdom (3)). By phase: Phase 1 (4), Phase 2 (3), Phase 3 (2), Phase 1/2 (1). The most active sponsors are University of California, San Francisco (2), Association for Innovation and Biomedical Research on Light and Image (2), University of Alabama at Birmingham (2). There are also 110 NIH-funded research projects on Diabetic Retinopathy, with $44.6 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 46Clinical trials
- 110NIH research projects
- 27Countries
Newest Diabetic Retinopathy clinical trials
All recruiting trials (46)
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Corticosteroid for Diabetic Macular Edema (DME) in Adults with Diabetic Retinopathy
This trial tests whether intravitreal corticosteroid injections can influence inflammatory biomarkers and improve DME in adults with type 2 diabetes.
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Automated detection of diabetic retinopathy lesions in fundus photos
This study tests a smart imaging system within the DDART device to see if it can reliably spot diabetic retinopathy lesions in color fundus photographs.
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Retinal microvascular changes in diabetic retinopathy measured with OCTA
This observational study tests how retinal blood vessel patterns seen on OCTA relate to vision and blood sugar control in adults with diabetic retinopathy.
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MK-8748 vs. aflibercept for diabetic macular edema
This trial tests whether the investigational medicine MK-8748 can treat diabetic macular edema as well as the standard treatment aflibercept in adults with diabetes.
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MK-8748 vs aflibercept for diabetic macular edema
This trial tests whether MK-8748 can treat diabetic macular edema as well as the standard treatment aflibercept in people with diabetes.
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Surabgene Lomparvovec in the Suprachoroidal Space for Diabetic Retinopathy
This study tests a one-time gene therapy called surabgene lomparvovec to see if it can help adults with non-proliferative diabetic retinopathy avoid vision-threatening events.
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RO7663498 eye injection safety in diabetic retinopathy
This study tests the safety, tolerability, and how the drug behaves in the body after an intravitreal injection for people with diabetic retinopathy.
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Hyperspectral imaging to map retinal and optic nerve structures
This study will test whether hyperspectral retinal imaging can detect disease-related features in adults with diabetic retinopathy, glaucoma, age-related macular degeneration, and in healthy volunteers.
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Tracking retinal changes over two years in people with moderate to early proliferative diabetic retinopathy
This project will try to find imaging, functional, and blood markers that show whether retinopathy is getting worse over two years in people with type 2 diabetes and moderate-to-mildly advanced disease.
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Finding eye changes that signal diabetic retinopathy progression and need for treatment
This study will try to see if specific retinal vessel and tissue changes measured with modern imaging can predict worsening diabetic retinopathy and cardiovascular risk in people aged 35 to 90 with type 2 diabetes.
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High Resolution Imaging OCT Study
This study tests whether two investigational OCT devices (R1 and HighRes OCT) produce better image quality than the standard Spectralis in adults with normal eyes or with AMD, diabetic retinopathy, or other retinal diseases.
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AI reading retinal photos for diabetic eye screening in primary care
This trial tests whether an artificial intelligence program can read retinal photos taken in primary care to screen adults with diabetes for diabetic retinopathy and macular edema instead of relying on ophthalmologists' reads.
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Vision screening in general practice to catch preventable sight loss in people over 70
This project will test a GP-based vision-screening program for people aged 70 and older with at least one chronic condition to find sight problems early.
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Watching a short video before anti-VEGF eye injections
This trial will test whether watching a brief procedural video before a first anti-VEGF intravitreal injection helps people with retinal diseases feel less anxious and have fewer or smaller subconjunctival hemorrhages.
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Community monitoring of diabetic eye conditions
This study is testing a new way for people with diabetes to have their eye conditions checked by local optometrists and doctors online to see if it makes monitoring easier and more effective.
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Improving follow-up after an eye screening referral
This trial tries text message or health worker reminders to help people referred after an eye screening get to their hospital appointment within 21 days.
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AI system for self-screening diabetic eye disease
This study is testing a new AI system that lets people with diabetes check their own eyes for signs of eye disease to see how well it works in different clinic settings.
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Using AI to screen for diabetic retinopathy
This study tests if an AI program can accurately find signs of diabetic retinopathy in eye images taken from people with diabetes.
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Improving diagnosis and treatment of diabetic retinopathy in type 2 diabetes
This study is testing a new way to spot and treat diabetic eye disease in people with type 2 diabetes by using a mix of health data and advanced technology to improve care.
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New peptide therapy for retinal diseases
This study is testing a new peptide therapy to see if it can help adults with retinal diseases like age-related macular degeneration and diabetic retinopathy improve their vision and eye health.
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Portable electroretinogram screening by an advanced practice nurse for diabetic retinopathy
This project will test whether a portable electroretinogram performed and read by an advanced practice nurse can detect diabetic retinopathy in adults with diabetes who have no known eye disease.
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Using AI to prevent vision loss from diabetes in underserved communities
This study is testing a new AI program to see if it can help people with diabetes in underserved communities get better eye care and follow-up after screenings.
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Remote ischemic conditioning to treat early diabetic retinopathy
This trial will test whether remote ischemic conditioning — brief, repeated arm cuff inflations — helps adults aged 40–80 with mild-to-moderate non-proliferative diabetic retinopathy.
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Testing THN391 for Diabetic Macular Edema
This study is testing a new drug called THN391 to see if it can safely help people with diabetic macular edema caused by diabetes.
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Comparing single-session and multiple-session laser treatment for diabetic eye disease
This study is testing whether one session or multiple sessions of laser treatment works better for people with newly diagnosed diabetic eye disease to help them keep their vision and avoid complications.
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Testing BI 764524 for treating diabetic retinopathy
This study is testing a new eye treatment called BI 764524 to see if it can help adults with moderate to severe diabetic retinopathy improve their eye health.
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Characterizing diabetes and obesity in Greenlandic patients
This study is trying to learn more about how genetics and environment affect type 2 diabetes and obesity in Greenlandic people, while also looking at related health issues like sleep apnea.
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Early angioplasty for diabetic foot syndrome
This study is testing if getting a quick angioplasty after being diagnosed with diabetic foot ulcers helps heal the wounds better than waiting for the procedure.
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Exploring new imaging techniques for eye diseases
This study is testing a new eye imaging technique to better understand diseases like diabetic retinopathy and macular degeneration in order to improve treatment for patients.
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Using AI Chatbots to Help Diabetic Patients
This study tests whether AI chatbots can help people with diabetes by giving them useful information on diet, stress management, and weight control, and compares their experiences with and without human support.
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Using stem cells from umbilical cords to treat non-arteritic ischemic optic neuropathy
This study is testing if using stem cells from umbilical cords can help people with non-arteritic ischemic optic neuropathy improve their vision and overall eye health.
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Identifying a biomarker for diabetic retinopathy
This study is trying to find a blood marker that can help show how healthy the eye blood vessels are in people with diabetic retinopathy.
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Using melatonin to improve sleep in patients with diabetic retinopathy
This study tests if taking melatonin can help people with diabetic retinopathy sleep better over eight weeks.
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Using advanced imaging to analyze retinal vascular diseases
This study is testing new imaging techniques to see how they can help doctors understand and track the progress of retinal diseases like diabetic retinopathy in both healthy people and those affected by these conditions.
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Program for screening and preventing diabetic retinopathy
This study is testing a new program that uses advanced technology to help find and manage diabetic retinopathy early in diabetes patients in China.
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Treatment for diabetic retinopathy with MS-553
This study is testing a new oral medication called MS-553 to see if it can improve vision and reduce swelling in the eyes of people with diabetic retinopathy.
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MB-102 versus fluorescein sodium for retinal angiography imaging
This trial will test whether the new dye MB-102 produces safe, high-quality retinal angiography images in adults with healthy eyes or retinal vascular disease compared with standard fluorescein sodium.
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Community-based eye screening program to prevent blindness
This study is testing whether a community eye screening program in Nepal can help prevent avoidable blindness by catching eye problems early.
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Using advanced imaging technology during eye surgery
This study is testing a new imaging technology during eye surgery to see if it can help doctors perform better and improve outcomes for patients with retinal diseases.
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Measuring sCD160 in eye fluids and blood to look for links with ischemic retinal diseases
This project tests whether sCD160 levels in the eye and blood are linked to ischemic retinal disease in adults having eye surgery.
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Using stem cells to repair blood vessels in diabetic eye disease
This study is testing if stem cells from the blood of diabetic patients can help repair damaged blood vessels in the eyes of people with diabetic eye disease.
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Exploring Liver X Receptor as a new target for treating Diabetic Retinopathy
This study is testing whether a new treatment that targets Liver X Receptors can help prevent diabetic retinopathy in people with diabetes.
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Levosulpiride treatment for diabetic eye conditions
This study is testing if a medication called levosulpiride can help improve eye problems caused by diabetes in people aged 40 to 69.
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Using advanced eye imaging to assess conditions and effects of a medical food
This study is testing how advanced eye imaging can help us understand eye conditions and see if a special medical food called Ocufolin can improve eye health over six months for both healthy people and those with eye issues.
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Analyzing eye fluid biomarkers in patients with retinal diseases
This study is trying to see if certain eye fluids can help us understand how serious retinal diseases like diabetic retinopathy and age-related macular degeneration are in patients.
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Biorepository for studying retinal diseases
This study is collecting health information and samples from people with and without eye diseases to see how these conditions develop and respond to treatments.
NIH-funded research (newest 40 of 110)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Integrative multi-omics to understand diabetic retinopathy
A doctor-scientist team will study blood markers and genetic signals to see why diabetic retinopathy happens and how it affects Hispanic/Latino people.
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Smartphone retinal imaging for diabetic eye disease in Egypt
This project uses a low-cost smartphone camera and AI to find signs of diabetic eye damage in adults with diabetes in Egypt.
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Retinal Cell Loss in Diabetic Retinopathy
This project looks at how mitochondrial problems and a specific kind of cell death called ferroptosis may cause retinal cells to die in people with diabetes-related eye disease.
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Redox-triggered REDD1 blockers for diabetic retinopathy
A research project tests new ways to stop a stress protein (REDD1) from causing vision problems in people with diabetic retinopathy.
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Ultrafast eye imaging to detect and track diabetic retinopathy
A doctor-science team is developing ultra-fast eye scans to better see tiny blood vessels in people with diabetic retinopathy, helping catch changes early and guide treatment.
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Practical device to automatically track abnormal retinal blood vessel growth in diabetic eye disease
A new, easier-to-use imaging device aims to automatically detect and monitor abnormal retinal blood vessel growth in people with diabetic retinopathy.
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Pro/renin receptor signaling and diabetic retinopathy
A diabetes-related eye disease called diabetic retinopathy will be studied to understand how a specific protein pathway contributes to eye damage.
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Retina-derived extracellular vesicles and diabetic retinopathy: possible roles in disease and therapy
Tiny vesicles from retinal cells may drive inflammation and damage in diabetic retinopathy, and this research looks at how they form, carry signals, and could be targeted for treatment.
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New ideas about how diabetic retinopathy damages the eye
A patient-focused look at how a molecule called PPARα may control inflammation in the retina to prevent or lessen diabetic retinopathy.
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RXR-based therapy to protect vision in diabetic retinopathy
Aims to deliver RXR-activating medicines directly into the eye to prevent or slow diabetic retinopathy in adults.
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Tiny particles from the retina and diabetic eye disease
This research looks at whether tiny particles released by retinal cells drive blood-vessel damage in diabetic retinopathy and could point to new treatments for people with diabetes-related vision loss.
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Sustained eye drops of fenofibrate to help people with diabetic retinopathy
A new eye-delivery system using tiny biodegradable nanoparticles may provide long-lasting fenofibrate in the retina to help people with diabetic retinopathy who don’t fully respond to current anti-VEGF treatments.
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Understanding how anti-VEGF injections affect retinal blood flow in diabetic eye disease
This project will use advanced eye imaging to see how anti-VEGF drugs change blood flow in the retina of people with diabetic retinopathy.
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Inflammaging and Diabetic Retinopathy in Adults
This NIH-funded project looks at why diabetes causes dangerous eye damage and how it might be prevented to preserve sight for adults.
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Epac1 as a new target to stop diabetic eye disease
A study in adults with diabetes aims to understand how Epac1 contributes to abnormal blood vessel growth in the retina and test whether targeting Epac1 could lead to better eye treatments.
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AI helps more people get diabetic retinopathy screening
A small study will look at how artificial intelligence-based eye screening can make it easier for adults with diabetes to get DR screening and treatment.
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Diabetic Retinopathy: Mitochondria, mtDNA, and Long Non-coding RNAs
A study at Wayne State University looks at how diabetes damages retinal cell powerhouses and their RNA to cause blindness, with potential for new therapies.
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Barber-CLIP: Expanding Vision Health Screening for Diabetic Retinopathy in Barbershops
A community-based program trains barbershop staff to screen men for diabetic retinopathy using tele-screening, linking them to eye care to prevent vision loss.
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Community Eye Connect: Using smart tools to boost follow-up after positive diabetic retinopathy screening
A multi-level health IT program helps people with diabetes at community health centers in Utah keep their eye care appointments after a positive retinopathy screening.
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Molecular triggers of diabetic retinopathy progression in adults
This grant explores how a specific cellular pathway linked to oxygen stress may drive eye damage in adults with diabetes, with the goal of stopping vision loss.
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Eye injection that targets RXR to treat diabetic retinopathy
This project aims to use a long‑lasting eye injection that activates RXR to reduce harmful fat buildup and inflammation in adults with diabetic retinopathy.
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Warburg metabolic switch in diabetic retinopathy
A study at Wayne State University will explore how retinal blood vessels change their energy use in people with long-standing diabetes to drive new blood vessel growth and vision loss.
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cGAS-STING signaling and monocyte activation in diabetic retinopathy
Aims to understand how a cell communication pathway called cGAS-STING affects monocytes and blood vessel leakage in diabetic retinopathy, and whether activating a protective receptor (PPARα) can help.
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Anti-ceramide therapy to protect the retina in diabetes
A doctor-scientist team is testing a targeted antibody approach to reduce inflammation and cell damage in the eyes of adults with diabetes who are at risk for vision loss.
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Early eye blood-vessel changes seen with OCTA that signal serious diabetic eye disease
Using a high-resolution eye scan called OCTA, researchers will look for early blood-vessel changes that predict serious diabetic eye problems in people with diabetic retinopathy.
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New treatment for diabetic eye disease using RXR therapy
This study is testing a new treatment for diabetic retinopathy that delivers special molecules directly to the eye to help reduce inflammation and improve eye health, which could lead to better vision for people with diabetes.
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Smartphone retinal imaging for diabetic eye disease in Egypt
This project is building a low-cost smartphone camera plus AI to spot diabetic eye damage for adults with diabetes in Egypt.
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Improving vision in diabetic patients by transferring mitochondria
This study is looking at how delivering healthy mitochondria from special cells can help improve energy in the eye cells of people with diabetic retinopathy, with the hope of preventing further damage and keeping their eyes healthier.
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Protecting vision in diabetes by targeting a key eye enzyme
This project tests whether boosting a molecule called soluble guanylate cyclase (sGC) can help protect the retinas of people with diabetic retinopathy.
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Using routine lab tests and health records to spot diabetic eye disease earlier
This project uses patterns in routine blood tests and electronic health records to help identify adults with diabetes who may have early diabetic retinopathy so they can get timely eye care.
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Targeting neutrophil traps and signals to protect the eye in diabetic retinopathy
Aims to understand how immune cells and their signals contribute to vision problems in adults with diabetes, with the goal of improving treatments for diabetic retinopathy.
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BMP2/ALK Signaling in Diabetic Retinopathy and Potential Therapies
This grant looks at how a specific signaling system in the eye may drive vision problems in diabetes and explores ways to block it to protect sight.
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Using AI across clinics to read eye scans for diabetic eye disease
This project trains AI on eye scans held at different hospitals to help doctors detect, predict, and track diabetic retinopathy in people with diabetes.
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Using fenofibrate to treat diabetic eye disease with a new delivery method
This study is testing a new way to give a medication called fenofibrate to help people with diabetes who have diabetic retinopathy, aiming to make treatment easier by reducing how often they need injections while improving their vision.
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Low-dose oral carbon monoxide for diabetic retinopathy
A low-dose oral carbon monoxide medicine aimed at protecting vision in adults with diabetic retinopathy.
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Understanding the causes of severe diabetic retinopathy
This study is looking into how a specific process in the eye can lead to serious vision problems for people with diabetes, and it hopes to find new ways to help prevent these issues for those affected by diabetic retinopathy.
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Targeting two retinal receptors linked to diabetic eye damage
Testing whether blocking two retinal receptors (GPR31 and GPR39) can reduce inflammation and abnormal blood-vessel growth that harm vision in people with diabetic retinopathy.
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Mitochondrial transfer to protect diabetic retinopathy patients’ eye vessels
A new approach tests whether giving healthy mitochondria to retinal cells can prevent blood vessel damage in people with diabetes-related eye disease.
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How neighborhood and local healthcare quality affect eye care for people with diabetes
This project looks at how where people live and the quality of local care relate to whether people with diabetes get recommended eye exams and follow-up to prevent vision loss.
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Targeting STING to treat diabetic eye disease
New medicines that block STING aim to reduce eye inflammation and prevent vision loss in people with diabetic retinopathy.
Related topics
Quick answers
How many Diabetic Retinopathy clinical trials are recruiting right now?
46, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 27 countries. The most sites are in United States (19 trials), China (5 trials), United Kingdom (3 trials), Australia (3 trials), Greece (2 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 4, Phase 2: 3, Phase 3: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.