NIH-funded research U01 cooperative agreement

AI-based glaucoma screening in community health centers

Official title: RFA-DP-24-081 Implementing AI-based Glaucoma Screening within Federally Qualified Health Centers

Funded at University of Alabama at Birmingham · NIH-11454104 · Data updated 2026-11-12

A new, easy-to-use AI screening approach will be tested in federally funded health centers to help identify people at risk for glaucoma, especially in communities with higher risk.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionUniversity of Alabama at Birmingham
NIH-funded
Lab location1 site (Birmingham, United States)
Project startSeptember 30, 2024
Project endSeptember 29, 2027
Funding year2026
Award (this year)$750,000
NIH project number5U01DP006827-03
Project IDNIH-11454104 on NIH RePORTER

Who could benefit from this research

Could help

Adults at risk for glaucoma who receive care at Federally Qualified Health Centers, especially individuals from populations with higher POAG risk.

Less likely to help

Patients not at risk for glaucoma or those not receiving eye care at participating centers may not benefit.

What this research studies

This project adapts a streamlined AI-assisted eye screening protocol to real-world clinics serving underserved populations. It uses images and clinical data to provide rapid interpretation and guide follow-up care, while studying how best to implement the program in everyday practice. The study combines feasibility testing with a comparative effectiveness component to see how well the intervention works in real clinics compared with current screening pathways.

Why it matters

Potential benefit: If successful, the program could enable earlier glaucoma detection and easier access to care for millions in underserved communities.

How similar studies have gone: Previous glaucoma screening work (including AI-based approaches) has shown promise, but real-world implementation in FQHCs is still being tested.

Where this research is happening

  • University of Alabama at Birmingham
    Birmingham, United States
    Active

Researchers

  • Principal investigator: Owsley, Cynthia — University of Alabama at Birmingham
  • Study coordinator: Owsley, Cynthia

Related research

Other NIH-funded projects on the same topics.

  • IOP and CSF Pressure in Glaucoma Risk

    This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11644421

  • Comparing tube positions in glaucoma implants to protect corneal cells

    This trial compares two tube placements for glaucoma drainage implants to see which better protects corneal cells and controls eye pressure in people with uncontrolled glaucoma.

    NIH research University of California, San Francisco · San Francisco, United States · NIH-11520347

  • Automated topographic test for glaucoma detection and progression

    A new automated method uses topographic structure-function mapping to help diagnose glaucoma earlier and track its progression in patients.

    NIH research Columbia University Health Sciences · New York, United States · NIH-11516608

  • Using AI on eye scans and genes to predict glaucoma risk

    This project uses artificial intelligence on eye scans, vision tests, and genetic information to find people most likely to develop or have worsening glaucoma.

    NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11469603

  • Understanding how glaucoma genes control eye cell function

    A long-term research project will study how genetic factors affect eye cells in adults with glaucoma to uncover new ideas for protecting vision.

    NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11450761

  • Targeted dendrimer-n-acetylcysteine for protecting vision in glaucoma

    A new patient-friendly treatment aims to deliver a neuroprotective drug directly to retinal cells to help people with glaucoma preserve their sight.

    NIH research Johns Hopkins University · Baltimore, United States · NIH-11450479

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.