Evaluating pupil response to light in patients with retinal conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the effectiveness of objective perimetry using a chromatic multifocal pupillometer to monitor visual field defects in patients with retinal dystrophies and glaucoma. The study will measure the pupil light reflex (PLR) in response to short and long wavelength light stimuli across 76 points in the visual field. By comparing the PLR of affected patients to that of healthy participants, the study seeks to establish a more accurate method for detecting visual field defects than traditional subjective perimetry.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-80 years old.
* Signing informed consent.
* Pupillary reflex to light.

Exclusion Criteria:

1. Cloudy corneas.
2. Surgical intraocular ophthalmic procedure within the past 30 days.
3. No reactive pupils.
4. Synechia of the iris to the lens after surgery or inflammation.
5. Neovascularization.
6. Axenfeld-Rieger Syndrome.
7. Iris atrophy (ICE syndrome).
8. Iris coloboma.
9. Sphincter damage due to ischemia.
10. Sphincter damage due to trauma (tears of sphincter or diffuse damage to muscle).
11. Sphincter damage due to Herpes Zoster Uveitis.
12. Sphincter damage due to high intraocular pressure.
13. Iris tumor or cyst.
14. Ectropion uvae.
15. Adie's pupil.
16. Third nerve aberrant regeneration of the iris sphincter.
17. RP patients with Optic neuropathy with the potential of producing a positive RAPD (Relative Afferent Pupillary Defect).
18. Chronic use of myotics or mydriatics.
19. Systemic medication that have affect on pupillary reflex .
20. Any condition preventing accurate measurement or examination of the pupil.

Where it's running

• Sheba Medical Center
  Tel HaShomer, Israel Recruiting

Study contacts

• Study coordinator: Ygal Rotenstreich, MD
• Email: Ygal.Rotenstreich@sheba.health.gov.il
• Phone: 972547898137

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.