Evaluating pupil response to light in patients with retinal conditions

Objective Perimetry in Normal Subjects,Glaucoma Patients and Retinal Dystrophy Patients

This study is testing a new way to check vision by measuring how pupils respond to light in people with retinal conditions like glaucoma to see if it’s better than current methods.

Quick facts

• Study type: Observational
• Enrollment: 200 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Sheba Medical Center (Government)
• Locations: 1 site (Tel Litwinsky)
• Trial ID: NCT02014389 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess the effectiveness of objective perimetry using a chromatic multifocal pupillometer to monitor visual field defects in patients with retinal dystrophies and glaucoma. The study will measure the pupil light reflex (PLR) in response to short and long wavelength light stimuli across 76 points in the visual field. By comparing the PLR of affected patients to that of healthy participants, the study seeks to establish a more accurate method for detecting visual field defects than traditional subjective perimetry.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18-80 with retinal dystrophies or glaucoma who can provide informed consent.

Not a fit: Patients with conditions affecting the pupillary reflex or recent ocular surgeries may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved monitoring and management of visual field defects in patients with retinal dystrophies and glaucoma.

How similar studies have performed: Other studies have shown promise in using objective measures for assessing visual field defects, suggesting this approach may be effective.

Eligibility criteria

Inclusion Criteria:

* Age 18-80 years old.
* Signing informed consent.
* Pupillary reflex to light.

Exclusion Criteria:

1. Cloudy corneas.
2. Surgical intraocular ophthalmic procedure within the past 30 days.
3. No reactive pupils.
4. Synechia of the iris to the lens after surgery or inflammation.
5. Neovascularization.
6. Axenfeld-Rieger Syndrome.
7. Iris atrophy (ICE syndrome).
8. Iris coloboma.
9. Sphincter damage due to ischemia.
10. Sphincter damage due to trauma (tears of sphincter or diffuse damage to muscle).
11. Sphincter damage due to Herpes Zoster Uveitis.
12. Sphincter damage due to high intraocular pressure.
13. Iris tumor or cyst.
14. Ectropion uvae.
15. Adie's pupil.
16. Third nerve aberrant regeneration of the iris sphincter.
17. RP patients with Optic neuropathy with the potential of producing a positive RAPD (Relative Afferent Pupillary Defect).
18. Chronic use of myotics or mydriatics.
19. Systemic medication that have affect on pupillary reflex .
20. Any condition preventing accurate measurement or examination of the pupil.

Where this trial is running

Tel Litwinsky

• Sheba Medical Center — Tel Litwinsky, Israel (Recruiting)

Study contacts

• Study coordinator: Ygal Rotenstreich, MD

Conditions Retinal Dystrophies; Retinitis Pigmentosa; Glaucoma; Visual Field