Assessing the Glycocalyx in Patients with Primary Open-angle Glaucoma
Official title: Assessment of Endothelial Glycocalyx in Patients With Primary Open-angle Glaucoma: a Prospective Single-center Cross-sectional Case-control Study
Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT05264818 · Data updated 2026-11-12
This study is testing a special imaging technique to see if the tiny blood vessels in people with primary open-angle glaucoma are working properly compared to those without eye problems.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | May 6, 2022 |
| Main results expected | May 2026 |
| Study ends | May 2026 |
| Registry record updated | December 8, 2025 |
| Trial ID | NCT05264818 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with primary open-angle glaucoma who exhibit visual field damage attributed to glaucomatous optic neuropathy.
✕Probably not a fit
Patients with conditions such as sleep apnea, renal insufficiency, or recent history of stroke or myocardial infarction may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the integrity of the microvascular system in patients with primary open-angle glaucoma using a specialized imaging technique called GlycoCheck. By measuring parameters such as capillary density, red blood cell filling percentage, and perfused boundary region, the study will generate a MicroVascular Health score (MVHS) to explore the ischemic theory of glaucoma. The study includes a case group of patients with glaucoma and a control group without optic nerve pathology. Participants will undergo ophthalmological examinations alongside the GlycoCheck assessment.
Why it matters
Potential benefit: If successful, this study could enhance understanding of glaucoma's underlying mechanisms and lead to improved diagnostic and therapeutic strategies.
How similar studies have gone: While the approach of assessing glycocalyx integrity in glaucoma is innovative, similar studies in other vascular conditions have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Express consent to participate in the study * Only for case group: primary open angle glaucoma (defined as the presence of visual field damage attributed to glaucomatous optic neuropathy) in both eyes * Only for control group: Absence optic nerve pathology (including primary open angle glaucoma) Exclusion Criteria: * Pregnant or breastfeeding woman * Sleep apnea * Renal insufficiency * Parkinson's disease * Alzheimer's disease * Antiphospholipid syndrome * Cancer for which treatment ended less than 2 years ago * Stroke less than 1 year ago * Myocardial infarction less than 1 year ago
Where it's running
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Hôpital Fondation A. de Rothschild
Paris, France Recruiting
Study contacts
- Principal investigator: Cédric LAMIREL, MD — Hôpital Fondation A. de Rothschild
- Study coordinator: Amélie YAVCHITZ, MD
- Email: ayavchitz@for.paris
- Phone: 01 48 03 64 33
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.