IOP and CSF Pressure in Glaucoma Risk
Official title: IOP and Cerebrospinal Fluid Pressure-related Risk Factors for Glaucoma
Funded at University of Alabama at Birmingham · NIH-11644421 · Data updated 2026-11-12
This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | December 1, 2015 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $230,754 |
| NIH project number | 3R01EY026035-09S1 |
| Project ID | NIH-11644421 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older who are at risk for glaucoma or undergoing eye pressure assessment may be eligible.
✕Less likely to help
Individuals without glaucoma risk factors or those not undergoing pressure assessments may have limited or no direct benefit.
What this research studies
Glaucoma is a major cause of irreversible vision loss, and this research examines how intraocular pressure and surrounding cerebrospinal fluid pressure interact at the optic nerve head. By measuring how pressure differences across the lamina cribrosa affect retinal nerve fibers, the project aims to identify why some people with similar eye pressures still develop glaucoma. The study uses human data and potentially related models to understand translaminar pressure dynamics and the role of lamina cribrosa thickness. Findings could lead to more personalized risk assessment and prevention strategies for glaucoma.
Why it matters
Potential benefit: If successful, the work could improve prediction of glaucoma risk and inform personalized approaches to prevent vision loss.
How similar studies have gone: Previous retrospective studies suggested a link between CSFP, IOP, and glaucoma risk, but continuous measurements are needed for stronger conclusions.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Downs, J Crawford — University of Alabama at Birmingham
- Study coordinator: Downs, J Crawford
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IOP and CSF Pressure Factors in Glaucoma
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.