Examining blood vessel changes in advanced glaucoma patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to analyze the progression of advanced glaucoma by comparing three examinations over three years: one functional test (visual field) and two anatomical tests (OCTa and OCTrnfl). Glaucoma is a chronic disease that leads to vision loss, and understanding the vascular changes around the optic nerve could provide insights into disease progression. The study utilizes optical coherence tomography angiography (OCTa), a non-invasive imaging method that visualizes retinal blood flow, to assess changes in the peripapillary vascular plexus. By correlating these findings with visual field deficits, the study seeks to enhance monitoring and management of glaucoma.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women aged 18 and over
* Patient with glaucoma followed in the ophthalmology department of Nantes University Hospital
* mean visual field deficit (MD) \>10dB

Exclusion Criteria:

* Retinal vascular pathology (moderate to severe non-proliferative diabetic retinopathy, complicated diabetic retinopathy, OVCR/OBVR, OACR/OBAR, NOIAA...) Non-glaucomatous optic neuropathy, neurological pathology leading to visual field deficit (stroke with HLH, quadranopsia, chiasmatic Sd...)
* PPR (retinal PanPhotocoagulation), retinal cerclage
* Retinal pathology leading to visual field impairment (e.g. retinitis pigmentosa)
* AMD and other macular pathologies that can lead to central visual field deficits
* Significant environmental disorders impairing retinal imaging (e.g. active uveitis, dense cataract)
* Loss of fixation point preventing visual field formation Pregnant or breast-feeding women
* Protected adults under guardianship or curatorship
* with unreliable visual fields (false positives and false negatives \> 33%)
* with an uninterpretable OCTrnfl or OCTa (artifact, low quality score)

Where it's running

• CHU Nantes
  Nantes, Nantes, France Recruiting
• Jean-Baptiste Ducloyer
  Nantes, Nantes, France Not yet recruiting

Study contacts

• Study coordinator: Jean-Baptiste Ducloyer, M.D
• Email: jeanbatiste.ducloyer@chu-nantes.fr
• Phone: 02 40 08 34 01

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.