Biofeedback training to improve vision in glaucoma
Efficacy of Biofeedback Training for Visual Function and Quality of Life in Glaucoma: A Randomized Controlled Trial
This study will test whether short sessions of visual biofeedback training can help people with glaucoma improve fixation stability, retinal sensitivity, and everyday vision.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Sex | All |
| Sponsor | University Health Network, Toronto Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT07409077 on ClinicalTrials.gov |
What this trial studies
This is a randomized controlled trial that will enroll 70 adults with glaucoma and paracentral scotomata and assign them 1:1 to either five weekly biofeedback training sessions or a control group receiving standard assessments. The intervention uses visual and auditory feedback during microperimetry to train eye movements toward retinal areas with better sensitivity and stability, with each session lasting about 20 minutes. Outcomes including fixation stability, retinal sensitivity, visual acuity, reading speed, contrast sensitivity, and vision-related quality of life will be measured at baseline and follow-up visits. The control group will be offered the training after completion of their study participation.
Who should consider this trial
Good fit: Adults aged 18–95 with a diagnosis of glaucoma, controlled intraocular pressure, paracentral scotomata within two degrees of fixation, and the ability to follow training instructions are the intended participants.
Not a fit: People with other significant ocular disease, media opacities that prevent reliable testing, prior low-vision rehabilitation, or who cannot perform study assessments are unlikely to benefit from or be eligible for this intervention.
Why it matters
Potential benefit: If successful, biofeedback training could help people with glaucoma make better use of their remaining vision and improve daily tasks like reading and mobility.
How similar studies have performed: Some small studies of visual biofeedback in other retinal conditions and low-vision populations have shown improvements in fixation and function, but evidence specifically in glaucoma is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-95 years old. * Glaucoma cases with adequate intraocular pressure control. * Presence of paracentral scotomata within two degrees of fixation. * Ability to follow instructions for biofeedback training. Exclusion Criteria: * Prior or current low vision rehabilitation treatment. * Ocular diseases or severe clinical conditions unrelated to glaucoma * Media opacities that prevent reliable microperimetry testing in both eyes. * Inability to perform study assessments or follow instructions for biofeedback training.
Where this trial is running
Toronto, Ontario
- University Health Network/ Toronto Western Hospital — Toronto, Ontario, Canada (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.