Optic Nerve Strain in Non-glaucoma Eyes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial uses a non-invasive imaging approach to measure biomechanical strain on the optic nerve at two intra-ocular pressure levels. It involves giving latanoprost to temporarily reduce eye pressure and capturing optic nerve images before and after the drop. Healthy adults over 30 without open-angle glaucoma (OAG) will be scanned, and results will be compared with glaucoma patients using the same methods. The study is conducted at Johns Hopkins with collaboration from the NEI and focuses on baseline biomechanical properties that may influence glaucoma analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults who have no history of OAG
* Have an ocular examination by a glaucoma specialist with no indications of OAG
* Have normal optical coherence tomography findings in the retinal nerve fiber layer.
* Over age 30 will be included from
* Both sexes
* All ethnic groups.
* Optic neuropathy.
* Both suspects and those with glaucoma damage will be included.
* When both eyes meet inclusion and exclusion criteria, both eyes will be included in the study and statistical methods will be used to account for correlations between eyes within the same individual.

Exclusion Criteria:

* in whom sitting in an upright position is impossible due to physical disability
* with ocular media opacity, corneal scarring, cataract or vitreous hemorrhage, that does not allow adequate imaging resolution.
* in whom keeping the eyes open during the imaging procedure is not possible or uncomfortable.
* who cannot perform home tonometry accurately at certification
* who do not have reliable clinical Optical Coherence Tomography (OCT) testing.
* with any form of glaucoma
* with high myopia defined as refractive error \> -8
* with past keratorefractive surgery, corneal dystrophy, or corneal ectasia that would make self-tonometry measurements difficult to interpret
* inability to understand English or with a language or hearing impairment

Where it's running

• Johns Hopkins Hospital
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Harry Quigley, MD — Johns Hopkins University
• Study coordinator: Harry A Quigley, MD
• Email: hquigley@jhmi.edu
• Phone: 410 955 6051

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Balance training for people with glaucoma

  A randomized study tests whether a structured eight-week balance program helps adults with glaucoma improve balance, reduce fall risk, and lessen fear of falling.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Küçükçekmece, Istanbul · NCT07910955

• Eye drops Rhopressa vs Timolol to protect nerve cells in glaucoma

  In adults with open-angle glaucoma, this study tests whether Rhopressa helps preserve retinal nerve cells better than Timolol while both lower eye pressure.

  Recruiting Phase 4 Indiana University · Bloomington, Indiana · NCT07847073

• Comparison of FT-1000 non-contact tonometry with Goldmann applanation tonometry in glaucoma patients

  This study tests whether the FT-1000 non-contact tonometer gives measurements that agree with the Goldmann applanation tonometer in adults with glaucoma.

  Recruiting Tomey Corporation · Jacksonville, Florida · NCT07804277

• Removing the ripcord from a glaucoma drainage device after 3 months

  This study tests whether removing the ripcord from an implanted glaucoma drainage device changes eye pressure for adults with open-angle glaucoma.

  Recruiting Duke University · Durham, North Carolina · NCT07803536

• Glaucoma and Brain Changes: How Brain Structure and Size See What Glaucoma Is Doing

  This study tests whether glaucoma is linked to broader brain changes by comparing brain MRI and eye health over time in people with glaucoma and matched controls.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT07802769

• Long-Term Results After Ab-interno Trabeculotomy for Glaucoma

  This study tests whether ab-interno trabeculotomy with the Trabectome can provide sustained intraocular pressure reduction in glaucoma patients who had the procedure between 2019 and 2021.

  Recruiting Wuerzburg University Hospital · Würzburg, Bavaria · NCT07780916

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.