Condition

Age-Related Macular Degeneration clinical trials and research

• 50Clinical trials
• 61NIH research projects
• 32Countries

Newest Age-Related Macular Degeneration clinical trials

All recruiting trials (50)

• Blepharoptosis After Repeated Anti-VEGF Injections in One Eye

  This study tests whether repeated intravitreal anti-VEGF injections in one eye affect eyelid position compared with the untreated fellow eye.

  Recruiting Fatih Sultan Mehmet Training and Research Hospital · Istanbul · NCT07821450

• First-in-human test of ARO-033 in adults

  This study tests whether ARO-033 is safe and tolerable, and how it behaves in the body, in healthy adults and in adults with age-related macular degeneration.

  Recruiting Phase 1 Arrowhead Pharmaceuticals · Auckland · NCT07662096

• Predicting Risk of AMD Progression Using Imaging in Aging Eyes

  Researchers are test a new screening approach to detect early AMD and monitor its progression in adults 55 and older, to see if personalized monitoring can help in community settings.

  Recruiting at 2 sites Singapore National Eye Centre · Singapore and 1 other locations · NCT07653269

• C.001 for retinal degeneration: a first-in-human dose-escalation safety test

  A first-in-human study will test the safety and tolerability of a single subretinal injection of C.001 in adults with retinal diseases involving retinal pigment epithelium degeneration.

  Recruiting at 2 sites Phase 1 Cellio Therapeutics Inc · Beverly Hills, California and 2 other locations · NCT07594236

• Central microperimetry and radial OCT in geographic atrophy

  We will test whether central microperimetry and radial OCT scans can more accurately measure how geographic atrophy progresses toward the fovea in people with or at risk for GA from age-related macular degeneration.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07556406

• Hyperspectral imaging to map retinal and optic nerve structures

  This study will test whether hyperspectral retinal imaging can detect disease-related features in adults with diabetic retinopathy, glaucoma, age-related macular degeneration, and in healthy volunteers.

  Recruiting Center for Eye Research Australia · Melbourne, Victoria · NCT07555574

• Tiespectus (MK-8748) versus aflibercept to treat neovascular (wet) age-related macular degeneration

  The study will see if tiespectus (MK-8748) works as well as aflibercept for people with newly diagnosed neovascular (wet) age-related macular degeneration.

  Recruiting at 71 sites Phase 2/3 EyeBiotech Ltd. · Gilbert, Arizona and 70 other locations · NCT07496567

• Personalized treat-and-extend faricimab regimen for treatment-naive polypoidal choroidal vasculopathy

  This tests whether a personalized treat-and-extend dosing schedule of faricimab (Vabysmo) helps people with newly diagnosed polypoidal choroidal vasculopathy keep or improve their vision.

  Recruiting Phase 3 Yeungnam University College of Medicine · Daegu, Namgu · NCT07461441

• Comparing tiespectus (MK-8748) with aflibercept for wet age-related macular degeneration

  This study will test whether tiespectus (MK-8748) works as well as aflibercept for people with newly diagnosed neovascular (wet) age-related macular degeneration.

  Recruiting at 132 sites Phase 2/3 EyeBiotech Ltd. · Scottsdale, Arizona and 131 other locations · NCT07440225

• High Resolution Imaging OCT Study

  This study tests whether two investigational OCT devices (R1 and HighRes OCT) produce better image quality than the standard Spectralis in adults with normal eyes or with AMD, diabetic retinopathy, or other retinal diseases.

  Recruiting Heidelberg Engineering GmbH · Milan · NCT07338461

• Eye-fluid signals linked to poor response to anti-VEGF in wet AMD

  This work tests whether analyzing eye fluid from people with treatment-naïve wet AMD who respond poorly to standard anti-VEGF injections can reveal other disease drivers and whether switching to faricimab improves vision outcomes.

  Recruiting Singapore National Eye Centre · Singapore · NCT07249216

• Eye injections of ABBV-6628 for geographic atrophy from age-related macular degeneration

  This trial will test whether intravitreal ABBV-6628 is safe and how the drug moves through the body in adults aged 50 and older with geographic atrophy from AMD.

  Recruiting at 5 sites Phase 1/2 AbbVie · Carmel, Indiana and 4 other locations · NCT07160179

• Vision screening in general practice to catch preventable sight loss in people over 70

  This project will test a GP-based vision-screening program for people aged 70 and older with at least one chronic condition to find sight problems early.

  Recruiting at 2 sites University of Copenhagen · Copenhagen, Capital Region and 1 other locations · NCT07015034

• Watching a short video before anti-VEGF eye injections

  This trial will test whether watching a brief procedural video before a first anti-VEGF intravitreal injection helps people with retinal diseases feel less anxious and have fewer or smaller subconjunctival hemorrhages.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07002372

• Improving follow-up after an eye screening referral

  This trial tries text message or health worker reminders to help people referred after an eye screening get to their hospital appointment within 21 days.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06943599

• Creating a dataset for Age-Related Macular Degeneration imaging

  This study is collecting eye images from people aged 50 and older to see if a new AI tool can help spot early signs of Age-Related Macular Degeneration and prevent vision loss.

  Recruiting at 13 sites University of Wisconsin, Madison · Atlanta, Georgia and 14 other locations · NCT06924021

• Evaluating progression and quality of life in patients with age-related macular degeneration

  This study is testing how age-related macular degeneration affects vision and quality of life in people over 50 to see what factors influence the disease's progression.

  Recruiting University of Udine · Udine, UD · NCT06899360

• New peptide therapy for retinal diseases

  This study is testing a new peptide therapy to see if it can help adults with retinal diseases like age-related macular degeneration and diabetic retinopathy improve their vision and eye health.

  Recruiting at 2 sites Phase 1/2 Ace Cells Lab Limited · Cairo and 1 other locations · NCT06787482

• Investigating vision changes in early age-related macular degeneration

  This study is trying to see how early changes in vision affect people with early age-related macular degeneration to help find better treatments in the future.

  Recruiting Fondation Ophtalmologique Adolphe de Rothschild · Paris · NCT06694272

• Microcurrent therapy for advanced age-related macular degeneration

  This study is testing a new device that uses microcurrents to see if it can improve vision and eye health in people with advanced age-related macular degeneration.

  Recruiting at 11 sites i-Lumen Scientific AUS PTY LTD · Poway, California and 12 other locations · NCT06662162

• Night-vision (rod) testing linked to everyday reading and mobility in AMD

  We will test whether reduced night vision (rod-mediated dark adaptation) is linked to reading and mobility performance in people 50 and older with early or intermediate AMD, subretinal drusenoid deposits, or healthy maculas.

  Recruiting Duke University · Durham, North Carolina · NCT06619405

• Assessing visual frailty in older adults with age-related macular degeneration

  This study is trying to see if a new tool can help understand how vision problems affect older adults with advanced age-related macular degeneration and their overall health.

  Recruiting University of Edinburgh · Edinburgh, Scotland and 1 other locations · NCT06604104

• Improving medication management for patients with vision loss

  This study is testing if personalized help from occupational therapy can improve medication management for people with vision loss from conditions like Age-Related Macular Degeneration, Diabetic Retinopathy, and Glaucoma.

  Recruiting Early Phase 1 MCPHS University · Worcester, Massachusetts · NCT06593405

• Impact of Lutein, Zeaxanthin, and Fish Oil on Health

  This study is testing if taking a daily supplement of lutein, zeaxanthin, and fish oil can help improve brain function, eye health, and bone strength in healthy adults aged 18-45 who have low eye pigment.

  Recruiting Texas A&M University · College Station, Texas · NCT06489873

• Gene therapy for treating neovascular age-related macular degeneration

  This study is testing a new gene therapy for people with neovascular age-related macular degeneration to see if a single injection can provide long-lasting treatment and reduce the need for frequent eye injections.

  Recruiting Phase 1/2 Chengdu Kanghong Pharmaceutical Group Co., Ltd. · Tianjin · NCT06458595

• Evaluating a stem cell treatment for geographic atrophy from dry age-related macular degeneration.

  This study is testing a new stem cell treatment for people with geographic atrophy from dry age-related macular degeneration to see if it can help improve their vision.

  Recruiting at 3 sites Phase 1/2 Eyestem Research Pvt. Ltd. · Jālna, Maharashtra and 2 other locations · NCT06394232

• Monitoring age-related macular degeneration using artificial intelligence

  This study is testing if using artificial intelligence with advanced imaging can help track how early and intermediate age-related macular degeneration progresses in people aged 55-99 over two years.

  Recruiting at 6 sites Medical University of Vienna · Vienna and 6 other locations · NCT06351670

• Monitoring progression of non-foveal age-related macular degeneration using artificial intelligence

  This study is testing how well artificial intelligence can help track the progression of a specific type of age-related macular degeneration in patients over two years.

  Recruiting at 6 sites Medical University of Vienna · Vienna and 6 other locations · NCT06351657

• Disulfiram (Antabuse) for vision in retinal degeneration

  This study will test whether taking oral disulfiram (Antabuse) improves vision in adults with retinal degeneration who are also being treated for alcohol use disorder.

  Recruiting Phase 1 University of Rochester · Rochester, New York · NCT06319872

• Switching patients with AMD from ranibizumab or aflibercept to faricimab

  This study is testing if switching people with age-related macular degeneration from their current eye injections to a new treatment called faricimab can improve their vision and reduce the number of injections they need.

  Recruiting Nantes University Hospital · Nantes, Nantes · NCT06271330

• Effects of Goji Berries on Age-Related Macular Degeneration

  This study is testing whether eating goji berries can help improve eye health in people aged 50 to 95 who are at risk for age-related macular degeneration.

  Recruiting University of California, Davis · Sacramento, California · NCT06237127

• Investigating early atrophic age-related macular degeneration

  This study is trying to learn more about early atrophic age-related macular degeneration to see how it affects vision and what might help prevent further vision loss for people experiencing this condition.

  Recruiting University of Utah · Salt Lake City, Utah · NCT05959005

• Using structured light to detect early signs of age-related macular degeneration

  This study is testing a new way to spot early signs of age-related macular degeneration using special light techniques to see if it can help people with vision problems get diagnosed sooner.

  Recruiting Centre for Eye and Vision Research · Hong Kong, Guangdong · NCT05913063

• Safety of BBC1501 intravitreal injection for people with neovascular age-related macular degeneration

  BBC1501 injected into the eye will be tested for safety and tolerability in people 50 and older with wet AMD who have not responded to at least two prior anti-VEGF treatments.

  Recruiting Phase 1 Benobio Co., Ltd. · Sydney, New South Wales and 1 other locations · NCT05803785

• Expressive arts intervention for adults with vision loss due to aging

  This study is testing a creative arts program to see if it can help adults aged 50 to 80 with vision loss from aging feel better and adjust to their changes in sight.

  Recruiting The University of Hong Kong · Hong Kong · NCT05675150

• Gene therapy for age-related vision loss

  This study is testing a new gene therapy for people aged 50 to 85 with age-related vision loss to see if a single injection can help improve their eyesight and reduce the need for ongoing treatments.

  Recruiting Phase 1/2 Chengdu Kanghong Pharmaceutical Group Co., Ltd. · Beijing · NCT05672121

• Krill oil to slow progression of early and intermediate dry age-related macular degeneration

  This trial will test whether taking four krill oil capsules daily for three months can slow progression in adults with early or intermediate dry age-related macular degeneration.

  Recruiting Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai · NCT05465252

• New telescope implant for patients with late-stage age-related macular degeneration

  This study is testing a new small telescope implant to see if it can help older patients with severe vision loss from age-related macular degeneration see better after surgery.

  Recruiting at 10 sites VisionCare, Inc. · Loma Linda, California and 9 other locations · NCT05438732

• Imaging of outer retinal diseases using adaptive optics

  This study is trying to take detailed pictures of the retina in people with outer retinal diseases to help find better ways to diagnose and understand these conditions.

  Recruiting at 2 sites Food and Drug Administration (FDA) · Bethesda, Maryland and 1 other locations · NCT05355415

• Understanding Age-Related Macular Degeneration and Its Progression

  This study looks at how age-related macular degeneration develops and progresses by comparing people with the condition to healthy individuals, using non-invasive tests and personal feedback.

  Recruiting Center for Eye Research Australia · East Melbourne, Victoria · NCT04739319

• Understanding Age-Related Macular Degeneration and Its Progression

  This study looks at how age-related macular degeneration develops and progresses by comparing people with the condition to healthy individuals, using non-invasive tests and personal feedback.

  Recruiting Center for Eye Research Australia · East Melbourne, Victoria · NCT04739319

• High-dose atorvastatin to improve dark adaptation in intermediate AMD

  This trial tests whether taking high-dose atorvastatin (80 mg) can speed dark adaptation recovery in people with high-risk intermediate age-related macular degeneration.

  Recruiting Phase 2 Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT04735263

• Investigating Monocytes in Patients with Atrophic Age-Related Macular Degeneration

  This study is testing how certain immune cells in people with atrophic age-related macular degeneration might affect the disease and looking for clues that could lead to new treatments.

  Recruiting at 2 sites Hospices Civils de Lyon · Lyon and 1 other locations · NCT04697095

• Improving reading for patients with central vision loss

  This study is testing different ways to help people with age-related macular degeneration read better by trying out techniques that adjust missing text.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT03848663

• Community-based eye screening program to prevent blindness

  This study is testing whether a community eye screening program in Nepal can help prevent avoidable blindness by catching eye problems early.

  Recruiting University of California, San Francisco · San Francisco, California · NCT03752840

• Testing a new treatment for vision loss in older adults with age-related macular degeneration

  This study is testing a new treatment using stem cells to see if it can help older adults with vision loss from age-related macular degeneration feel better and improve their sight.

  Recruiting at 13 sites Phase 1 Astellas Pharma Inc · Phoenix, Arizona and 19 other locations · NCT03178149

• Using stem cells to treat retinal and optic nerve damage

  This study is testing if using stem cells from your own bone marrow can help improve vision in people with serious eye damage from conditions like age-related macular degeneration and optic nerve problems.

  Recruiting at 4 sites MD Stem Cells · Westport, Connecticut and 3 other locations · NCT03011541

• Switching from ranibizumab to aflibercept for eye conditions

  This study is testing if switching patients with certain eye conditions from one medication to another can help improve their vision.

  Recruiting Medical University of Vienna · Vienna · NCT02669953

• High-resolution imaging of the retina

  This study is testing a new way to take detailed pictures of the retina to help doctors better understand and treat eye diseases like Stargardt's and age-related macular degeneration in people aged 7 and older.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT01866371

• Biorepository for studying retinal diseases

  This study is collecting health information and samples from people with and without eye diseases to see how these conditions develop and respond to treatments.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01496625

NIH-funded research (newest 40 of 61)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• AI-powered tool to predict 2-year risk of late AMD

  A new AI software helps people at risk of age-related macular degeneration understand their 2-year risk and what steps could protect their vision.

  NIH research Ihealthscreen, INC. · Richmond Hill, UNITED STATES · NIH-11552709

• Active cycling program to support vision and daily living in Veterans with AMD

  A 6-month online group spin cycling program is tested to help Veterans with age-related macular degeneration maintain vision and improve daily functioning.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-11456784

• Transplanting stem-cell–derived retinal cells to treat dry AMD

  A medical team is testing a stem cell therapy to replace damaged retinal cells in adults with dry age-related macular degeneration.

  NIH research Regenerative Research Foundation · Albany, UNITED STATES · NIH-11439991

• RPESC-derived RPE Transplant for Dry AMD in adults

  A new cell-based therapy derived from RPESCs is being tested to help adults with dry age-related macular degeneration regain vision.

  NIH research Regenerative Research Foundation · Albany, UNITED STATES · NIH-11436542

• New high-resolution OCT biomarkers to map early AMD changes

  A new imaging approach using advanced OCT methods will help doctors see early changes in age-related macular degeneration to guide treatment and improve quality of life for older adults.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11431137

• Targeting inflammation in age-related macular degeneration

  Aims to understand how inflammation drives age-related macular degeneration in people and explore new targets to slow or stop vision loss.

  NIH research Yale University · New Haven, United States · NIH-11418964

• Early atrophic AMD: understanding how the disease progresses to protect vision

  This NIH grant studies how age-related macular degeneration advances in its early atrophic stage to help prevent vision loss.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11418467

• Inhibiting new blood vessel growth and scarring under the retina in AMD

  This grant tests drug-based strategies to prevent abnormal blood vessel growth and scarring under the retina in adults with age-related macular degeneration.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11418408

• Non-exudative Type 1 MNV and AMD: protect vision with smarter imaging

  This project studies how a specific, non-exudative form of eye blood vessels in AMD might help preserve vision, using advanced eye imaging and patient-friendly tests.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11418359

• PRMT5 inhibitors for tough-to-treat age-related eye disease

  A new PRMT5 inhibitor is being explored as a treatment for people with neovascular age-related macular degeneration who don’t fully respond to current anti-VEGF therapies.

  NIH research Eqon Pharmaceuticals, LLC · Carmel, United States · NIH-11409867

• Predicting 2-year risk of age-related macular degeneration with AI

  A patient-friendly AI tool is being developed to predict who is at higher risk of developing late AMD within the next two years.

  NIH research Ihealthscreen, INC. · Richmond Hill, UNITED STATES · NIH-11399767

• Understanding how a protein called osteopontin affects aging eyes and dry age-related macular degeneration

  A researcher at Duke is studying how osteopontin, a protein involved in inflammation, may contribute to aging of the eye and the most common cause of vision loss in older adults.

  NIH research Duke University · Durham, United States · NIH-11384499

• Role of ARMS2 mutations in age-related macular degeneration

  This grant explores how ARMS2 genetic changes may drive age-related macular degeneration and how these changes cause AMD-related eye damage in mouse models.

  NIH research Jackson Laboratory · Bar Harbor, United States · NIH-11384282

• Metabolomics approach to uncover how age-related macular degeneration develops

  A patient-facing look at how we study small molecules in blood and eye tissue to understand why people develop AMD and how it progresses.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11380958

• OCT Angiography for Age-related Macular Degeneration

  A patient-friendly look at using advanced eye imaging to help diagnose and monitor age-related macular degeneration, with the goal of protecting vision.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11379944

• Role of Bruch Membrane Heparan Sulfate in Drusen Formation in Age-Related Macular Degeneration

  Researchers are studying how a sugar molecule on Bruch’s membrane may influence the buildup of drusen and progression of age-related macular degeneration to guide new treatments.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11374972

• Understanding how non-coding genetic risk affects AMD in the eye

  A study explores how non-coding genetic differences near the 10q26 region contribute to age-related macular degeneration and tests new therapeutic ideas.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11367610

• Gene therapy to protect vision in age-related macular degeneration

  A patient-focused gene therapy approach aims to slow or prevent progression of intermediate AMD to more advanced stages.

  NIH research Oculogenex · Dallas, UNITED STATES · NIH-11311499

• Efficient photostress recovery biomarkers for age-related macular degeneration

  A small NIH-funded project will test quick, easy biomarkers of how well people with age-related macular degeneration recover after light exposure to help track disease progression and treatment effects.

  NIH research Perzeption INC. · Littleton, UNITED STATES · NIH-11310564

• Maximizing Visual Potential for People with Age-Related Macular Degeneration

  This grant investigates how people with age-related macular degeneration adapt their eye movements and attention to use the best remaining vision to perform everyday tasks.

  NIH research Smith-Kettlewell Eye Research Institute · San Francisco, United States · NIH-11298071

• Rebuilding the blood–retina barrier to learn how APOE gene types affect macular degeneration

  Researchers will grow a human retinal tissue with blood-vessel channels to learn how different APOE gene types influence age-related macular degeneration in people.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11270833

• Humanin-like gene and mitochondrial health in age-related macular degeneration

  This project looks at a gene called MTRNR2L1 and how it affects the energy-making parts of eye cells in people with age-related macular degeneration.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11267232

• Inflammasome-driven inflammation in age-related macular degeneration

  This work looks at how two inflammation proteins, AIM2 and NLRP3, may cause or worsen wet age-related macular degeneration to help find better treatments for people with AMD.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11259425

• Dissecting retinal glial regulome to refine AMD risk genes and networks

  This project looks at how genetic and epigenetic changes in retinal glial cells contribute to age-related macular degeneration, with the goal of better understanding why some people develop AMD.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11224284

• Exercise program to help Veterans with age-related macular degeneration keep vision and daily function

  Veterans with intermediate age-related macular degeneration will join a 6-month online group spin cycling program to try to preserve vision, thinking, and everyday functioning.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-11222659

• Ribozyme treatment to reduce toxic retinal pigments in dry macular degeneration

  This project will develop a ribozyme treatment to break down toxic pigments in the retina and help protect vision for people with dry age-related and juvenile macular degeneration.

  NIH research VA Western New York Healthcare System · Buffalo, United States · NIH-11218694

• Reducing harmful inflammation in wet age-related macular degeneration

  This project looks for ways to block damaging immune inflammation in people with neovascular (wet) age-related macular degeneration to help protect their vision.

  NIH research Yale University · New Haven, United States · NIH-11172498

• Tool to predict your 2-year risk of late age-related macular degeneration

  This AI tool predicts whether people with early or intermediate age-related macular degeneration are likely to develop late AMD within two years.

  NIH research Ihealthscreen, INC. · Richmond Hill, UNITED STATES · NIH-11146532

• Improving Vision for Veterans with Macular Degeneration

  This project explores new ways to help Veterans with age-related macular degeneration regain some vision by teaching their brains to use touch more effectively.

  NIH research Charlie Norwood VA Medical Center · Augusta, United States · NIH-11144249

• Stopping abnormal blood vessel growth and scar tissue under the retina in wet age-related macular degeneration

  This project tests new drug approaches to prevent abnormal blood vessels and scarring under the retina in adults with neovascular (wet) age-related macular degeneration.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11142546

• A new approach to treat dry age-related macular degeneration

  This study is exploring a new treatment for dry age-related macular degeneration and juvenile macular degeneration by using special tools to help clear out harmful substances in the eye, with the hope of protecting and improving vision for those affected.

  NIH research VA Western New York Healthcare System · Buffalo, United States · NIH-11138540

• How sex affects mitochondrial and epigenetic factors in age-related vision loss.

  This study is looking at how being male or female might affect the way age-related macular degeneration (AMD) develops, especially in women over 60, to help find better treatments tailored to each person's needs.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11134035

• Measuring small molecules to better understand age-related macular degeneration

  This project will measure specific small molecules in people with age-related macular degeneration to find signals that predict progression.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11131651

• Osteopontin's role in aging eyes and macular degeneration

  This project looks at how a protein called osteopontin affects retinal cells in older adults and may contribute to dry age-related macular degeneration.

  NIH research Duke University · Durham, United States · NIH-11131110

• Non-leaky (Type 1) macular blood vessels and age-related macular degeneration

  This project looks at whether a quiet, non-leaking form of new blood vessels in the macula helps protect vision in people with age-related macular degeneration.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11123162

• Improving OCT Angiography to Find and Monitor Age-related Macular Degeneration

  This project develops clearer OCT angiography scans and AI tools to find and track harmful blood-vessel changes in people with age-related macular degeneration.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11123132

• Tracking early atrophic changes in age-related macular degeneration

  This project follows people with early atrophic (dry) AMD using detailed eye imaging and vision tests to see who is most likely to lose vision.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11117094

• Understanding a Key Component in Age-Related Macular Degeneration

  This work explores how a specific sugar molecule in the eye's support layer contributes to the deposits that cause vision loss in dry age-related macular degeneration.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11101418

• ARMS2 gene changes and age-related macular degeneration

  This project looks at whether a common ARMS2 gene change (A69S) causes AMD and how it damages the retina to help people with age-related macular degeneration.

  NIH research Jackson Laboratory · Bar Harbor, United States · NIH-11099960

• Investigating a new gene related to age-related macular degeneration

  This study is looking at a specific gene that might be important in understanding how age-related macular degeneration (AMD) develops, with the hope that what they learn could help create better treatments for people dealing with this eye condition.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11062896

Related topics

Quick answers

How many Age-Related Macular Degeneration clinical trials are recruiting right now?

50, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 32 countries. The most sites are in United States (23 trials), Australia (7 trials), France (6 trials), United Kingdom (5 trials), Spain (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 5, Phase 1: 5, Phase 2/3: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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