NIH-funded research R01 grant

Monitoring advanced glaucoma with AI to track central vision

Official title: Monitoring of Glaucoma Patients in Advanced Disease

Funded at University of California, San Diego · NIH-11418939 · Data updated 2026-11-12

A study at UC San Diego uses computer-based AI tools to watch how severe glaucoma changes the central vision and macula over time so doctors can tailor care.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of California, San Diego
NIH-funded
Lab location1 site (La Jolla, United States)
Project startSeptember 1, 2022
Project endAugust 31, 2027
Funding year2026
Award (this year)$515,556
NIH project number5R01EY034148-05
Project IDNIH-11418939 on NIH RePORTER

Who could benefit from this research

Could help

Individuals with advanced open-angle glaucoma and measurable central visual field function.

Less likely to help

Patients with less advanced glaucoma or other eye diseases not meeting the advanced criteria may not benefit from this approach.

What this research studies

People with very advanced glaucoma often retain only a tiny central vision, making monitoring difficult. This project follows patients over time to map how central vision and macular structure change and to build AI-powered models that can detect and predict progression. It will combine central visual field data with new macular imaging to improve prediction of worsening vision. The goal is to give clinicians better guidance for when to adjust treatments in advanced disease.

Why it matters

Potential benefit: If successful, patients with advanced glaucoma could receive more accurate monitoring and timely treatment changes to protect remaining vision.

How similar studies have gone: Previous work suggests AI can help detect glaucoma progression, but this study targets the challenging advanced stage with central vision focus.

Where this research is happening

  • University of California, San Diego
    La Jolla, United States
    Active

Researchers

  • Principal investigator: Moghimi Araghi, Sasan — University of California, San Diego
  • Study coordinator: Moghimi Araghi, Sasan

Related research

Other NIH-funded projects on the same topics.

  • IOP and CSF Pressure in Glaucoma Risk

    This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11644421

  • Comparing tube positions in glaucoma implants to protect corneal cells

    This trial compares two tube placements for glaucoma drainage implants to see which better protects corneal cells and controls eye pressure in people with uncontrolled glaucoma.

    NIH research University of California, San Francisco · San Francisco, United States · NIH-11520347

  • Automated topographic test for glaucoma detection and progression

    A new automated method uses topographic structure-function mapping to help diagnose glaucoma earlier and track its progression in patients.

    NIH research Columbia University Health Sciences · New York, United States · NIH-11516608

  • Using AI on eye scans and genes to predict glaucoma risk

    This project uses artificial intelligence on eye scans, vision tests, and genetic information to find people most likely to develop or have worsening glaucoma.

    NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11469603

  • AI-based glaucoma screening in community health centers

    A new, easy-to-use AI screening approach will be tested in federally funded health centers to help identify people at risk for glaucoma, especially in communities with higher risk.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11454104

  • Understanding how glaucoma genes control eye cell function

    A long-term research project will study how genetic factors affect eye cells in adults with glaucoma to uncover new ideas for protecting vision.

    NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11450761

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.