Comparing the effects of two types of eye drops on eye health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of benzalkonium-chloride preserved eye drops versus preservative-free eye drops on conjunctival goblet cells in patients with open-angle glaucoma or ocular hypertension. A total of 28 subjects will participate, applying one type of eye drop in each eye for three months. The study is randomized and investigator-blind, ensuring unbiased results. Before and after the treatment period, conjunctival prints will be taken to evaluate changes in goblet cell density and intraocular pressure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age \>18years
2. Danish speaking
3. Open angle glaucoma or ocular hypertension
4. Average intraocular pressure equal to or above 22 mmHg

Exclusion Criteria:

a. history of significant eye diseae (including okular trauma) other than open angle glaucoma and ocular hypertension d. treatment with steroids within the last 3 months from inclusion e. Significant untreated systemic disease such as hypertension, heart failure, diabetes mellitus, stroke, lung disease and autoimmune diseases. Diseases are not reason for exclusion if they are well treated or does not need treatment g. pregnant or breast feeding h. women using unsafe anticonception i. allergy towards trial medication j. patients who cannot cooperate in eye examination k. ocular surface defects l. need for polytherapy in glaucoma treatment

Where it's running

• Department of drug design and pharmacology, University of Copenhagen
  Copenhagen, Denmark Recruiting
• Department of ophthalmology, rigshospitalet.glostrup
  Glostrup Municipality, Danmark, Denmark Not yet recruiting

Study contacts

• Principal investigator: Miriam Kolko, MD, PhD — Department of ophthalmology, rigshospitalet-Glostrup
• Study coordinator: Anne Nagstrup, MD
• Email: anne.hedengran.nagstrup@regionh.dk
• Phone: +4522334504

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.