Investigating genetic factors in different types of glaucoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify genetic risk factors associated with pseudoexfoliation syndrome (PXF), primary angle closure glaucoma (PACG), and primary open-angle glaucoma (POAG) using a whole genome association approach. By analyzing blood samples from patients with these conditions and healthy controls, the study seeks to uncover susceptibility genes that may play a role in the development of glaucoma. The findings could enhance understanding of ocular development and lead to improved diagnostic and prognostic tools for these glaucoma types.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. For patients with PXF:

   * Patients with confirmed pseudoexfoliation syndrome (exfoliation glaucoma / pseudoexfoliation of the lens) in the medical history
   * Informed consent
   * Age 50 years or more
2. For patients with PACG:

   * Patients with confirmed acute primary angle closure (PAC) or primary angle closure glaucoma (PACG) in the medical history
   * Informed consent
   * Age 21 years or more
3. For healthy controls:

   * No evidence of PXF, glaucoma or uveitis during clinical examination or in the medical history
   * No evidence of major ocular disease such as diabetic retinopathy, age related macular degeneration or conditions with genetic background during clinical examination or in the medical history
   * Age more than 60 years
   * Informed consent
4. For patients with POAG:

   * Patients with confirmed primary open angle glaucoma (POAG)
   * No evidence of exfoliation glaucoma / pseudoexfoliation of the lens or pigment glaucoma
   * Informed consent
   * Age 30 or more

Exclusion Criteria:

* Patients and subjects will be excluded if one or more of the following criteria apply:
* Neovascular glaucoma
* Active or history of uveitis
* Secondary angle closure such as neovascular glaucoma or uveitis/inflammatory eye disease
* Inability to give informed consent

Where it's running

• Department of Clinical Pharmacology, Medical University of Vienna
  Vienna, Austria Recruiting

Study contacts

• Principal investigator: Gerhard Garhöfer — Medical University of Vienna
• Study coordinator: Gerhard Garhöfer
• Email: gerhard.garhoefer@meduniwien.ac.at
• Phone: 0140 400 29880

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.