Clinical trial Recruiting at 1 site Observational

Relieving eye-surface discomfort in glaucoma patients using multiple eye drops

Official title: Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications

Run by University of California, Los Angeles · NCT04354545 · Data updated 2026-11-12

This will try Xiidra eye drops to relieve ocular surface discomfort in people with glaucoma who are using one or more topical glaucoma medications.

Quick facts

Study typeObservational
SexAll
Enrollment75 (estimated)
SponsorUniversity of California, Los Angeles
Academic / other
Locations1 site (Fountain Valley, California)
StatusRecruiting
StartedApril 1, 2021
Main results expectedDecember 1, 2026
Study endsDecember 1, 2026
Registry record updatedMarch 13, 2026
Trial IDNCT04354545 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are people with glaucoma who are using at least one topical glaucoma eye drop, report ocular surface discomfort, and whose clinician plans to prescribe Xiidra as standard care.

Probably not a fit

Patients with a history of glaucoma filtration or ocular surface surgery, those who had incisional ocular surgery in the past six months, or those currently using topical cyclosporine or steroids are unlikely to benefit from this observational evaluation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project follows glaucoma patients who are prescribed Xiidra (lifitegrast 5%) as part of routine care to address ocular surface discomfort related in part to topical glaucoma medications. Participants are adults already using one or more topical glaucoma antihypertensives and reporting symptoms of ocular surface discomfort, while patients with recent ocular surgery or current topical cyclosporine or steroid use are excluded. Researchers will document symptom changes and tolerability after Xiidra prescription without altering the treating clinician's plan. The work is conducted at Doheny Eye Center UCLA in Fountain Valley, California, with treatment provided as standard of care.

Why it matters

Potential benefit: If successful, this could reduce eye-surface discomfort and make glaucoma medication use more comfortable for affected patients.

How similar studies have gone: Lifitegrast (Xiidra) is FDA-approved and has shown benefit for dry eye disease in prior studies, but its specific effects in glaucoma patients on multiple topical medications have been less well studied.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Currently using one or more topical glaucoma antihypertensives
* Self-described symptoms of ocular surface discomfort
* Xiidra is being prescribed as part of the subject's standard care

Exclusion Criteria:

* History of glaucoma filtration surgery, history of ocular surface surgery (pterygium, conjunctivoplasty, etc.),
* current use of topical cyclosporine
* current use of topical steroids
* incisional ocular surgery within 6 months

Where it's running

  • Doheny Eye Center UCLA
    Fountain Valley, California, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.