Relieving eye-surface discomfort in glaucoma patients using multiple eye drops
Official title: Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications
Run by University of California, Los Angeles · NCT04354545 · Data updated 2026-11-12
This will try Xiidra eye drops to relieve ocular surface discomfort in people with glaucoma who are using one or more topical glaucoma medications.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | University of California, Los Angeles Academic / other |
| Locations | 1 site (Fountain Valley, California) |
| Status | Recruiting |
| Started | April 1, 2021 |
| Main results expected | December 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | March 13, 2026 |
| Trial ID | NCT04354545 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people with glaucoma who are using at least one topical glaucoma eye drop, report ocular surface discomfort, and whose clinician plans to prescribe Xiidra as standard care.
✕Probably not a fit
Patients with a history of glaucoma filtration or ocular surface surgery, those who had incisional ocular surgery in the past six months, or those currently using topical cyclosporine or steroids are unlikely to benefit from this observational evaluation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational project follows glaucoma patients who are prescribed Xiidra (lifitegrast 5%) as part of routine care to address ocular surface discomfort related in part to topical glaucoma medications. Participants are adults already using one or more topical glaucoma antihypertensives and reporting symptoms of ocular surface discomfort, while patients with recent ocular surgery or current topical cyclosporine or steroid use are excluded. Researchers will document symptom changes and tolerability after Xiidra prescription without altering the treating clinician's plan. The work is conducted at Doheny Eye Center UCLA in Fountain Valley, California, with treatment provided as standard of care.
Why it matters
Potential benefit: If successful, this could reduce eye-surface discomfort and make glaucoma medication use more comfortable for affected patients.
How similar studies have gone: Lifitegrast (Xiidra) is FDA-approved and has shown benefit for dry eye disease in prior studies, but its specific effects in glaucoma patients on multiple topical medications have been less well studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Currently using one or more topical glaucoma antihypertensives * Self-described symptoms of ocular surface discomfort * Xiidra is being prescribed as part of the subject's standard care Exclusion Criteria: * History of glaucoma filtration surgery, history of ocular surface surgery (pterygium, conjunctivoplasty, etc.), * current use of topical cyclosporine * current use of topical steroids * incisional ocular surgery within 6 months
Where it's running
-
Doheny Eye Center UCLA
Fountain Valley, California, United States Recruiting
Study contacts
- Study coordinator: Benjamin B Bert, MD
- Email: BBert@mednet.ucla.edu
- Phone: 626-817-4701
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.