Rocklatan added after DSLT for open-angle glaucoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-masked study conducted at a single site to compare two treatment strategies after Direct Selective Laser Trabeculoplasty (DSLT). Participants receive either the combination eye drop Rocklatan plus latanoprost or latanoprost alone, with outcomes measured mainly by changes in diurnal intraocular pressure. Key visits occur at screening/DSLT, a post-washout baseline, and a follow-up at week 12, including IOP measurements, visual field, and OCT imaging. The study enrollment targets adults with bilateral mild to moderate POAG or OAG who are on three glaucoma medications at screening and have suitable IOP after DSLT and washout.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults (≥18 years) with a diagnosis of mild to moderate bilateral primary open-angle glaucoma (POAG) or open-angle glaucoma (OAG).
* On 3 topical glaucoma medications at screening, one of which must be a prostaglandin analog.
* Post-DSLT and post-washout, baseline intraocular pressure (IOP) 16-36 mmHg in both eyes.
* Best-corrected visual acuity (BCVA) ≥20/60 in both eyes.
* Ability and willingness to provide informed consent.

Exclusion Criteria:

* Ocular hypertension only (no glaucomatous damage).
* Inability or medical ineligibility for washout of ocular hypotensive medications.
* Prior selective laser trabeculoplasty (SLT) within 12 months of screening.
* History of glaucoma surgery (trabeculectomy, tube shunt, minimally invasive glaucoma surgery \[MIGS\] affecting outflow).
* Narrow or closed angles with gonioscopy (Shaffer grading ≤2).
* Active ocular infection, uveitis, or severe dry eye.
* Corneal pathology interfering with IOP measurement.
* Advanced glaucoma (threat to fixation).
* Known hypersensitivity to Rocklatan, latanoprost, or study medication components.
* Pregnancy or lactation.

Where it's running

• Eye Centers of Southeast Texas
  Beaumont, Texas, United States Recruiting

Study contacts

• Principal investigator: Kevin Talbot, MD — Eye Centers of Southeast Texas

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.