Improving mobility in glaucoma patients using video games and exercise

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to enhance mobility and reduce the fear of falling in glaucoma patients with peripheral vision loss through an innovative intervention involving action video games and physical training. Participants will be randomly assigned to either an interactive video game training group or a conventional physical training group, with both groups undergoing 20 sessions over 10 weeks. The study will assess various outcomes related to mobility, balance, visual cognition, and quality of life before and after the intervention. The goal is to provide a fun and engaging way to improve rehabilitation outcomes for patients with visual impairments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Presence of moderate to severe bilateral glaucomatous optic neuropathy (GON) from primary open-angle (including normal tension) or angle-closure glaucoma, as determined by an ophthalmologist, with abnormal Glaucoma Hemifield Test on standard Humphrey Field Analyzer 24-2 testing and matching nerve-fiber layer thinning on optical coherence tomography;
2. Stable vision and visual field loss for at least 3 months;
3. With a best-corrected distance acuity of 6/12 or better (equivalent to 0.3 logMAR acuity or better to confirm that participant's central vision is preserved);
4. With a cognitive functional score of 22 or above in the Montreal Cognitive Assessment - Hong Kong version (to confirm participants' intact cognitive function).

Exclusion Criteria:

1. Advanced glaucoma with GON of median deviation worse than -25 decibel;
2. Ocular diseases other than glaucoma (e.g., age-related macular degeneration, diabetic retinopathy, and moderate to severe cataract);
3. Severe medical problems (e.g., stroke, Parkinson's disease) or self-reported neurological (e.g. brain surgery, brain tumor and peripheral neuropathy), or cognitive disorders (e.g., diagnosed dementia or cognitive impairment);
4. Physical impairments (e.g. need the use of orthopedic and mobility aids) or physical limitations restricting them from independent walking;
5. Self-reported or medically diagnosed vestibular/ cerebellar dysfunction, history of vertigo, or severe hearing loss;
6. Using any medications for any neurological conditions or psychiatric drugs (e.g. sedative, hypnotic) that might interfere motor control; and
7. Currently attending any intensive physical/balance training.

Where it's running

• The Hong Kong Polytechnic University
  Hong Kong, Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Allen Cheong, PhD — The Hong Kong Polytechnic University
• Study coordinator: Allen Cheong, PhD
• Email: allen.my.cheong@polyu.edu.hk
• Phone: 852-27666108

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.