Observing changes in the eye's drainage angle after surgery
Biometric Changes After Intervention of Anterior Chamber Angle : an Observational Study
Zhongshan Ophthalmic Center, Sun Yat-sen University · NCT06492538
This study looks at how different eye surgeries can help people with glaucoma by checking the changes in their eye drainage angle after the procedures.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 30 Years to 85 Years |
| Sex | All |
| Sponsor | Zhongshan Ophthalmic Center, Sun Yat-sen University (other) |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT06492538 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with glaucoma who are undergoing various minimally invasive angle interventions to improve aqueous humor outflow. The research team will utilize imaging techniques to monitor the healing of the anterior chamber angle tissues post-surgery. By employing methods such as laser peripheral iridotomy and goniosynechialysis, the study aims to enhance understanding and standardization of these surgical techniques. The goal is to track biometric changes that may lead to better outcomes for patients suffering from angle-closure glaucoma.
Who should consider this trial
Good fit: Ideal candidates include glaucoma patients eligible for angle intervention surgeries like laser peripheral iridotomy or goniosynechialysis.
Not a fit: Patients with severe ocular conditions or systemic diseases that could interfere with the study may not benefit.
Why it matters
Potential benefit: If successful, this study could lead to improved surgical techniques and outcomes for patients with angle-closure glaucoma.
How similar studies have performed: Other studies have shown promise in minimally invasive glaucoma surgeries, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Glaucoma patients eligible for standalone or combined angle intervention surgeries, such as LPI, LPIP, goniosynechialysis, trabeculotomy alone or combined with surgical iridectomy or phacoemulsification and intraocular lens implantation; * Patients capable of undergoing preoperative examinations including CASIA2-OCT (anterior segment OCT), UBM, slit-lamp gonioscopy, IOL Master (or other optical biometry); * Patients willing to participate in this study, signing informed consent, and agreeing to follow-up according to the study protocol. Exclusion Criteria: * Patients with severe ocular conditions such as corneal infection, ulcer, trauma, ocular tumors, retinal vascular occlusion, and retinal detachment; * Those with various types of eye diseases that affect ocular parameter acquisition or interfere with visual field examination; * Long-term local or systemic use of glucocorticoids; * Patients with severe systemic diseases; * Pregnant or lactating women; * Unable to complete 12-month postoperative follow-up.
Where this trial is running
Guangzhou, Guangdong
- Zhongshan ophthalmic center — Guangzhou, Guangdong, China (RECRUITING)
Study contacts
- Principal investigator: Xinbo Gao, MD — State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
- Study coordinator: Xinbo Gao, MD
- Email: gaoxb@mail.sysu.edu.cn
- Phone: +8618319579657
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Angle-closure Glaucoma, Minimally Invasive Glaucoma Surgery, Goniosynechialysis, Goniotomy, Glaucoma