Choroid and retina imaging in angle‑closure versus open‑angle glaucoma using OCT and OCTA
Official title: Choroidal and Retinal Features in PACD and POAG on OCT and OCTA
Run by Zhongshan Ophthalmic Center, Sun Yat-sen University · NCT07580014 · Data updated 2026-11-12
This project will use OCT and OCTA eye scans to see if choroidal and retinal features differ between people with primary angle‑closure disease, primary open‑angle glaucoma, and healthy volunteers.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 132 (estimated) |
| Sponsor | Zhongshan Ophthalmic Center, Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | July 16, 2024 |
| Main results expected | April 20, 2027 |
| Study ends | April 20, 2027 |
| Registry record updated | May 12, 2026 |
| Trial ID | NCT07580014 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with a glaucoma specialist–confirmed diagnosis of POAG or PACD (PACS/PAC/PACG) or healthy volunteers with IOP <21 mmHg, symmetric cup‑to‑disc ratios <0.5 and no history of ocular surgery.
✕Probably not a fit
People with retinal or macular diseases (for example AMD or diabetic retinopathy), non‑glaucomatous optic neuropathies, prior relevant ocular surgery, or those unable to produce high‑quality OCT/OCTA images are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will use optical coherence tomography (OCT) and OCT angiography (OCTA) to measure choroidal and retinal structural and vascular features in people with primary angle‑closure disease (PACS/PAC/PACG), primary open‑angle glaucoma (POAG), and healthy controls. Participants are enrolled based on glaucoma specialist–confirmed diagnosis using ISGEO staging or control criteria (no ocular surgery, intraocular pressure <21 mmHg, cup‑to‑disc ratio <0.5 bilaterally without asymmetry). Key exclusions include retinal or macular disease, non‑glaucomatous optic neuropathy, poor OCT/OCTA image quality, and refusal to consent. All imaging and evaluations are performed at Zhongshan Ophthalmic Center in Guangzhou to compare choroidal thickness, retinal layer measures, and microvascular parameters between groups.
Why it matters
Potential benefit: If successful, this could help clinicians use noninvasive OCT/OCTA scans to better distinguish PACD from POAG or detect glaucoma‑related changes earlier.
How similar studies have gone: OCT and OCTA have been widely used in glaucoma research and have shown promise for detecting retinal and microvascular changes, but using choroidal features to distinguish PACD from POAG remains an emerging area with mixed evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Control group: Healthy individuals with no history of ocular surgery, IOP \< 21 mmHg, and CDR \< 0.5 bilaterally without asymmetry * Observation group: Glaucoma specialist-confirmed diagnosis of POAG or PACD (per ISGEO staging: PACS/PAC/PACG) Exclusion Criteria: * History of retinal or macular disease (e.g., AMD, DR, RVO, ERM) * Non-glaucomatous optic neuropathy (e.g., MS, NMO) * Poor OCT/OCTA image quality * Refusal to sign informed consent
Where it's running
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Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Study coordinator: Yuheng Tan
- Email: tanyuhesper@163.com
- Phone: +02066615461
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.