Choroid and retina imaging in angle‑closure versus open‑angle glaucoma using OCT and OCTA
Choroidal and Retinal Features in PACD and POAG on OCT and OCTA
This project will use OCT and OCTA eye scans to see if choroidal and retinal features differ between people with primary angle‑closure disease, primary open‑angle glaucoma, and healthy volunteers.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 132 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Zhongshan Ophthalmic Center, Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT07580014 on ClinicalTrials.gov |
What this trial studies
This observational study will use optical coherence tomography (OCT) and OCT angiography (OCTA) to measure choroidal and retinal structural and vascular features in people with primary angle‑closure disease (PACS/PAC/PACG), primary open‑angle glaucoma (POAG), and healthy controls. Participants are enrolled based on glaucoma specialist–confirmed diagnosis using ISGEO staging or control criteria (no ocular surgery, intraocular pressure <21 mmHg, cup‑to‑disc ratio <0.5 bilaterally without asymmetry). Key exclusions include retinal or macular disease, non‑glaucomatous optic neuropathy, poor OCT/OCTA image quality, and refusal to consent. All imaging and evaluations are performed at Zhongshan Ophthalmic Center in Guangzhou to compare choroidal thickness, retinal layer measures, and microvascular parameters between groups.
Who should consider this trial
Good fit: Ideal candidates are adults with a glaucoma specialist–confirmed diagnosis of POAG or PACD (PACS/PAC/PACG) or healthy volunteers with IOP <21 mmHg, symmetric cup‑to‑disc ratios <0.5 and no history of ocular surgery.
Not a fit: People with retinal or macular diseases (for example AMD or diabetic retinopathy), non‑glaucomatous optic neuropathies, prior relevant ocular surgery, or those unable to produce high‑quality OCT/OCTA images are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this could help clinicians use noninvasive OCT/OCTA scans to better distinguish PACD from POAG or detect glaucoma‑related changes earlier.
How similar studies have performed: OCT and OCTA have been widely used in glaucoma research and have shown promise for detecting retinal and microvascular changes, but using choroidal features to distinguish PACD from POAG remains an emerging area with mixed evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Control group: Healthy individuals with no history of ocular surgery, IOP \< 21 mmHg, and CDR \< 0.5 bilaterally without asymmetry * Observation group: Glaucoma specialist-confirmed diagnosis of POAG or PACD (per ISGEO staging: PACS/PAC/PACG) Exclusion Criteria: * History of retinal or macular disease (e.g., AMD, DR, RVO, ERM) * Non-glaucomatous optic neuropathy (e.g., MS, NMO) * Poor OCT/OCTA image quality * Refusal to sign informed consent
Where this trial is running
Guangzhou, Guangdong
- Zhongshan Ophthalmic Center, Sun Yat-sen University — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Study coordinator: Yuheng Tan
- Email: tanyuhesper@163.com
- Phone: +02066615461
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.