Using blood flow imaging to assess glaucoma
Official title: Ocular Blood Flow Imaging for Glaucoma Assessment
Run by University of Maryland, Baltimore · NCT05726058 · Data updated 2026-11-12
This study is testing whether new imaging tools can help doctors see differences in blood flow in the eyes of people with glaucoma compared to healthy individuals.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 88 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | University of Maryland, Baltimore Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Status | Recruiting |
| Started | March 30, 2023 |
| Main results expected | December 31, 2027 |
| Study ends | April 30, 2028 |
| Registry record updated | July 2, 2026 |
| Trial ID | NCT05726058 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals aged 18 and older with binocular vision, either healthy controls or those recommended for glaucoma assessment or diagnosed with moderate to severe glaucoma.
✕Probably not a fit
Patients with significant media opacity, previous ocular surgeries (other than uncomplicated cataract extraction), or other ocular diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of the XyCAM RI and XyCAM FC, FDA-cleared retinal blood flow imaging instruments, in managing glaucoma. The study aims to determine if blood flow measurements can differentiate between early-stage glaucoma and matched controls, while also validating the simultaneous capture of stereo fundus photography and ocular blood flow monitoring. Participants will undergo a series of imaging tests, including blood flow imaging and standard clinical assessments, to gather comprehensive data on their ocular health. The trial will involve both healthy controls and patients diagnosed with moderate to severe glaucoma.
Why it matters
Potential benefit: If successful, this study could enhance the accuracy of glaucoma assessments and improve patient management strategies.
How similar studies have gone: Other studies utilizing advanced imaging techniques for glaucoma assessment have shown promise, indicating potential success for this novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 and older with binocular vision * Able to provide informed consent * Patient is a healthy control OR is recommended for glaucoma assessment OR diagnosed with moderate to severe glaucoma in at least one eye as determined by Hodapp Anderson Criteria Exclusion Criteria: * The subject has significant media opacity (e.g., a visually significant cataract or significant corneal scar) * The subject has previous ocular surgery other than uncomplicated cataract extraction, laser trabeculoplasty (ALT or SLT), or YAG capsulotomy * The subject has prior ocular disease other than glaucoma * The subject has anatomically narrow angles or a prior adverse reaction to administration of Tropicamide or fluorescein dye * The subject has more than 15 diopters of refractive error * The subject is a female who is pregnant or nursing * The subject has diabetes mellitus
Where it's running
-
University of Maryland Eye Associates at Redwood
Baltimore, Maryland, United States Recruiting
Study contacts
- Study coordinator: Osamah J Saeedi, MD, MS
- Email: osaeedi@som.umaryland.edu
- Phone: (410) 328-5929
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Balance training for people with glaucoma
A randomized study tests whether a structured eight-week balance program helps adults with glaucoma improve balance, reduce fall risk, and lessen fear of falling.
-
Eye drops Rhopressa vs Timolol to protect nerve cells in glaucoma
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This study tests whether the FT-1000 non-contact tonometer gives measurements that agree with the Goldmann applanation tonometer in adults with glaucoma.
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This study tests whether removing the ripcord from an implanted glaucoma drainage device changes eye pressure for adults with open-angle glaucoma.
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Glaucoma and Brain Changes: How Brain Structure and Size See What Glaucoma Is Doing
This study tests whether glaucoma is linked to broader brain changes by comparing brain MRI and eye health over time in people with glaucoma and matched controls.
-
Long-Term Results After Ab-interno Trabeculotomy for Glaucoma
This study tests whether ab-interno trabeculotomy with the Trabectome can provide sustained intraocular pressure reduction in glaucoma patients who had the procedure between 2019 and 2021.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.