Condition

Retinal Disease clinical trials and research

• 18Clinical trials
• 13NIH research projects
• 16Countries

Newest Retinal Disease clinical trials

All recruiting trials (18)

• Multimodal Eye Data Bank to Explore Inflammation-Related Eye Diseases

  This observational effort collects rich eye-imaging data from people with inflammatory and retinal conditions to see how the front and back of the eye relate and to build a standardized database that could support future AI tools.

  Recruiting Capital Medical University · Beijing · NCT07628946

• Tracking retinal changes over two years in people with moderate to early proliferative diabetic retinopathy

  This project will try to find imaging, functional, and blood markers that show whether retinopathy is getting worse over two years in people with type 2 diabetes and moderate-to-mildly advanced disease.

  Recruiting Association for Innovation and Biomedical Research on Light and Image · Coimbra · NCT07458516

• OCT data collection from healthy and diseased eyes (A10900)

  This project will collect Optical Coherence Tomography (OCT) scans from adults 22 and older who have retinal disease, glaucoma, corneal conditions, or are healthy to build a reference dataset for A10900.

  Recruiting at 3 sites Optos, PLC · Anaheim, California and 3 other locations · NCT07149740

• Choriocapillaris blood flow differences in people with pseudoxanthoma elasticum versus healthy adults

  We will test whether a noninvasive eye scan (OCT angiography) shows reduced choriocapillaris blood flow in adults with pseudoxanthoma elasticum compared with matched healthy adults.

  Recruiting University Hospital, Angers · Angers · NCT07006649

• Sepofarsen injections for LCA10 due to the CEP290 p.Cys998X mutation

  This study will test whether sepofarsen eye injections can improve vision in children and adults with LCA10 caused by the CEP290 c.2991+1655A>G (p.Cys998X) mutation.

  Recruiting at 17 sites Phase 3 Laboratoires Thea · San Francisco, California and 17 other locations · NCT06891443

• Auto-aligning handheld OCT for adult and pediatric retinal imaging

  We will test a new handheld OCT device that automatically aligns to capture retinal images in healthy adults, adult eye patients, and children.

  Recruiting Duke University · Durham, North Carolina · NCT06841575

• Using a short vitrectomy probe for pediatric eye surgeries

  This study tests a new shorter tool for eye surgery in children to see if it makes the surgery safer and easier for doctors.

  Recruiting Phase 4 Chang Gung Memorial Hospital · Taoyuan · NCT06520410

• Genetics Navigator: a digital platform to guide people through genetic testing

  This randomized trial will test whether the Genetics Navigator digital platform helps adults and parents of children referred for clinical genetic testing have less distress and a smoother testing process compared with usual genetics appointments.

  Recruiting at 3 sites Unity Health Toronto · Toronto, Ontario and 2 other locations · NCT06455384

• Evaluating a stem cell treatment for geographic atrophy from dry age-related macular degeneration.

  This study is testing a new stem cell treatment for people with geographic atrophy from dry age-related macular degeneration to see if it can help improve their vision.

  Recruiting at 3 sites Phase 1/2 Eyestem Research Pvt. Ltd. · Jālna, Maharashtra and 2 other locations · NCT06394232

• Comparing two imaging systems for inherited retinal disease

  This study is testing whether two new eye imaging systems can provide similar information as a standard system for people with inherited retinal diseases.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06380075

• Comparing two OCT imaging systems for pediatric retina evaluation

  This study is testing two different eye imaging systems to see which one works better for looking at the retinas of children.

  Recruiting Duke University · Durham, North Carolina · NCT06139523

• Exploring new imaging techniques for eye diseases

  This study is testing a new eye imaging technique to better understand diseases like diabetic retinopathy and macular degeneration in order to improve treatment for patients.

  Recruiting Johannes Kepler University of Linz · Linz, Upper Austria · NCT06074731

• Using advanced imaging technology during eye surgery

  This study is testing a new imaging technology during eye surgery to see if it can help doctors perform better and improve outcomes for patients with retinal diseases.

  Recruiting Duke University · Durham, North Carolina · NCT03713268

• Using stem cells to treat retinal and optic nerve damage

  This study is testing if using stem cells from your own bone marrow can help improve vision in people with serious eye damage from conditions like age-related macular degeneration and optic nerve problems.

  Recruiting at 4 sites MD Stem Cells · Westport, Connecticut and 3 other locations · NCT03011541

• Registry for inherited retinal degenerative diseases

  This study is creating a registry for people with rare inherited eye diseases to help track their health and experiences over time, making it easier to understand these conditions and support research.

  Recruiting Foundation Fighting Blindness · Columbia, Maryland · NCT02435940

• Biorepository for studying retinal diseases

  This study is collecting health information and samples from people with and without eye diseases to see how these conditions develop and respond to treatments.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01496625

• Collecting cells to study eye diseases

  This study is collecting hair, skin, and blood samples from people with certain eye diseases to see how these conditions develop and find new treatments.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01432847

• Investigating genetic factors in Plaquenil-induced retinal toxicity

  This study is trying to see if certain genetic changes in people can help explain why some patients develop eye problems from the medication Plaquenil while others do not.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01145196

NIH-funded research (13)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Integrative Curation of Clinically Relevant Variants in X-Linked Inherited Retinal Disease Genes

  A project to expand expert review of genetic variants linked to X‑linked inherited retinal diseases so patients can access gene therapies.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11413431

• Intravitreal gene therapy for inherited retinal disease

  A specialized gene therapy approach delivered inside the eye is being studied to help children with inherited retinal diseases maintain or improve vision.

  NIH research University of California at Davis · Davis, United States · NIH-11380542

• Retinal Disease: Molecular Basis and Pathophysiology

  A gene mutation linked to retinal disease is studied to understand how it changes cellular pathways and leads to vision problems.

  NIH research Jackson Laboratory · Bar Harbor, United States · NIH-11370637

• Genes that change how inherited retinal disorders behave

  This work looks for other genes that change how CRB1-related inherited retinal diseases affect children and adults who carry CRB1 mutations.

  NIH research Jackson Laboratory · Bar Harbor, United States · NIH-11302629

• A new antibody drug to restore the retina’s protective barrier

  This project tests a novel antibody designed to boost a natural signaling pathway to strengthen the retina’s protective barrier for people with retinal diseases that cause leaking or inflammation.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11249977

• Eye-injection gene therapy for inherited retinal disease

  A gene therapy delivered by an injection into the eye aims to treat inherited forms of retinal degeneration, including in children.

  NIH research University of California at Davis · Davis, United States · NIH-11115686

• Clear genetic answers for X-linked inherited retinal diseases

  Building a trusted catalog of gene changes linked to X-linked inherited retinal diseases so people can get more accurate genetic diagnoses and access gene therapies.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11096712

• Investigating new treatments for age-related macular degeneration

  This study is looking at how certain vitamin A-related compounds might help improve vision for older adults with age-related macular degeneration (AMD), and it aims to find new treatments that could make life better for those dealing with this condition.

  NIH research Veterans Health Administration · Long Beach, United States · NIH-11061800

• Investigating genetic factors that influence retinal diseases

  This study is looking at how changes in the CRB1 gene can cause eye conditions like Leber Congenital Amaurosis and retinitis pigmentosa, and it aims to find out how genetics and the environment can influence the different ways these conditions show up in people, so we can better understand and help those affected.

  NIH research Jackson Laboratory · Bar Harbor, United States · NIH-11046663

• Exploring a new treatment for retinal diseases using a specific agonist

  This study is exploring a new treatment that could help protect and heal the retina, which is important for good vision, and it might lead to better options for people with eye conditions like diabetic retinopathy and macular degeneration.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11006269

• Examining trends in diabetic retinal disease in the U.S.

  This study is looking into how common diabetic retinal disease is, especially among different racial and ethnic groups, to help improve eye care and treatment for people with diabetes.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11002694

• Understanding genetic variants in inherited retinal diseases

  This study is working to help people with inherited retinal diseases by bringing together experts to better understand the genetic changes that cause these conditions, so that patients can get more accurate diagnoses and access to new treatments that are being tested.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10892188

• Imaging techniques for eye diseases using advanced ultrasound technology

  This study is testing a new 3D ultrasound system to take clearer pictures of the inside of your eye, which could help doctors better diagnose and treat eye diseases.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-10664131

Related topics

Quick answers

How many Retinal Disease clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (11 trials), Canada (2 trials), Austria (2 trials), France (2 trials), Taiwan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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