Condition

Cataract clinical trials and research

• 68Clinical trials
• 24NIH research projects
• 3New in 30 days
• 27Countries

Newest Cataract clinical trials

All recruiting trials (68)

• Rotational Stability of the Acunex Vario Toric

  This study tests whether the Acunex Vario toric extended-depth-of-focus intraocular lens stays stable in rotation and effectively reduces astigmatism for people undergoing cataract surgery.

  Recruiting Vienna Institute for Research in Ocular Surgery · Vienna · NCT07925840

• Anterior segment anatomy assessment with swept-source OCT in eye surgery patients

  This study tests whether swept-source OCT can detail front-eye anatomy in patients undergoing anterior segment eye surgery.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT07903454

• MiLOOP-assisted cataract surgery for dense cataracts

  In people with dense cataracts, this study tests whether using the miLOOP device during cataract surgery can protect corneal cells and reduce ultrasound energy, compared with standard surgery.

  Recruiting Universiti Kebangsaan Malaysia Medical Centre · Cheras, Kuala Lumpur · NCT07898007

• Visual adaptation and quality of life after different IOL implantation options

  This study follows adults who have cataracts and receive bilateral multifocal or mixed IOLs to see how their vision and daily life improve over 6 months.

  Recruiting Sichuan Academy of Medical Sciences · Chengdu · NCT07740590

• Corneal Biomechanics and Surgical Astigmatism after Cataract Surgery in Pseudoexfoliation

  This study tests how the cornea's biomechanical properties before cataract surgery relate to the amount of blinking surgically induced astigmatism, comparing people with pseudoexfoliation to those without.

  Recruiting Eye Clinic Medic Zuljan Jukic · Split, Splitsko-dalmatinska County · NCT07722247

• Neuroplastic pain education and guided breathing during awake cataract surgery

  This trial tests whether the STEIN Protocol, a non-drug approach with pain education, guided imagery, and paced breathing, helps adults having cataract surgery require less pain medicine and feel less anxious.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT07715591

• Bilateral Implantation of enVista Envy Trifocal IOL for Cataract Patients

  This study tests whether the enVista Envy trifocal intraocular lens can provide good distance, intermediate, and near vision after cataract surgery in adults who want less dependence on glasses.

  Recruiting Pomeranian Medical University Szczecin · Szczecin, Zachodnipomorskie · NCT07696130

• Smart bed-exit alerts to keep cataract patients safe before surgery

  A randomized trial tests whether a smart bed-exit alert system helps prevent bed exits and improves nursing efficiency for adults waiting for cataract surgery.

  Recruiting National Taiwan University Hospital · Taipei · NCT07693829

• Bilateral Clareon IOLs in Cataract Patients: TruPlus vs Monofocal

  This study tests whether implanting Clareon TruPlus bilateral IOLs works as well as Clareon monofocal bilateral IOLs in adults with cataracts.

  Recruiting Phase 4 Berkeley Eye Center · Sugar Land, Texas · NCT07693205

• tRF-31 and HIPK2 in age-related cataract: a look at eye tissue and surgery outcomes

  This observational study tests whether the tRF-31/HIPK2 signaling axis in the eye relates to cataract severity in adults with age-related cataract.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07672899

• Clareon TruPlus vs Tecnis Eyhance IOLs for cataract surgery

  This study compares two types of intraocular lenses implanted in both eyes of adults with cataracts to see which provides better vision after three months.

  Recruiting Gainesville Eye Associates · Gainesville, Georgia · NCT07658040

• Effect of Dry Eye Treatment on Corneal Astigmatism Measurements

  This study tests whether short-term treatment for dry eye changes how consistently three devices measure corneal astigmatism in people preparing for cataract surgery.

  Recruiting Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT07657858

• Clareon TruPlus Intraocular Lens Outcomes in Cataract Surgery

  This study tests Clareon TruPlus intraocular lenses in adults undergoing cataract surgery to see how well they perform visually and respond to patient-reported questions up to 3 months after the procedure.

  Recruiting OVO LASIK + Lens · Saint Louis Park, Minnesota · NCT07648355

• Lacrifill for dry eye and precise eye measurements in cataract patients

  This study tests Lacrifill canalicular filler in adults with dry eye undergoing cataract surgery to see if it improves tear film and measurement accuracy.

  Recruiting The Eye Institute of West Florida · Largo, Florida · NCT07648095

• Smartphone-based AI eye disease screening for anterior segment conditions

  A smartphone-powered AI system tests whether it can identify 16 eye conditions from images captured on a phone, without needing internet access, in adults.

  Recruiting Zhongshan Ophthalmic Center, Sun Yat-sen University · Guangzhou, Guangdong · NCT07634913

• Post-refractive IOL Outcomes With Clareon TruPlus in Cataract Patients

  This study tests how well the Clareon TruPlus intraocular lens works in adults who had prior myopic corneal refractive surgery and are undergoing cataract surgery.

  Recruiting Laser Defined Vision · Greensboro, North Carolina · NCT07610226

• Binaural Beats During Cataract Surgery in Older Adults

  This study tests whether listening to binaural beats during cataract surgery helps patients aged 65 and older feel more comfortable and satisfied with the procedure.

  Recruiting Seoul National University Hospital · Seoul · NCT07609186

• Comparison of a new trifocal IOL with PanOptix Pro IOL in cataract surgery

  This study tests whether the investigational trifocal IOL LPYWT0 works as well as the PanOptix Pro trifocal IOL in people with cataracts undergoing cataract surgery in both eyes.

  Recruiting Alcon Research · Sydney, New South Wales and 4 other locations · NCT07587138

• Sedation with dexmedetomidine, propofol, or both during cataract surgery

  This project will test whether dexmedetomidine, propofol, or their combination (each given with fentanyl) provides the best sedation, safety, and surgeon satisfaction for adults having cataract surgery.

  Recruiting Saint-Joseph University · Beirut · NCT07556133

• Toric IOL performance and constants optimization after cataract surgery

  This test checks the safety and how well a monofocal toric intraocular lens performs, to fine-tune its power settings for people undergoing cataract surgery.

  Recruiting at 3 sites Phase 4 Carl Zeiss Meditec AG · Prague, Prague and 5 other locations · NCT07471295

• Robotic-assisted cataract surgery using the ORYOM system

  This will test whether the ORYOM robotic system can safely help perform cataract surgery in adults aged 55 to 80.

  Recruiting ForSight Robotics Ltd · Makati City, National Capital Region · NCT07468409

• Analyzing eye fluid and tissues to find glaucoma-related markers in people with cataracts.

  This study will test whether protein and elemental patterns in eye fluid and tissues taken during cataract surgery differ between people with primary open-angle glaucoma and those without glaucoma.

  Recruiting at 2 sites Military Institute od Medicine National Research Institute · Warsaw and 1 other locations · NCT07462000

• How three toric intraocular lenses rotate after cataract surgery

  This study tests how well three commercial toric intraocular lenses hold their orientation over the first three months after cataract surgery in adults with corneal astigmatism.

  Recruiting Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT07453992

• Detailed eye imaging after presbyopia‑correcting lens implantation using OCT and pyramid aberrometry

  This project will test whether detailed OCT and pyramid wavefront imaging can describe how well presbyopia‑correcting intraocular lenses perform in people after cataract surgery.

  Recruiting at 2 sites Vienna Institute for Research in Ocular Surgery · Vienna and 1 other locations · NCT07436247

• Measuring eye pressure and fluid outflow during cataract or glaucoma surgery

  This will test whether measuring eye pressure and fluid outflow during cataract or glaucoma surgery with a disposable sensor can help predict and improve recovery for adults having these operations.

  Recruiting The New York Eye & Ear Infirmary · New York, New York · NCT07425496

• Registry of cataract surgery outcomes after phacoemulsification with different intraocular lenses.

  This project will collect data to see how people who have phacoemulsification do with different types of intraocular lenses.

  Recruiting Sensor Cliniq · Warsaw · NCT07276217

• Comparing two trifocal toric intraocular lenses for cataract surgery.

  This trial will test two different trifocal toric intraocular lenses to see which gives better intermediate-distance vision and satisfaction for adults with cataracts and regular corneal astigmatism.

  Recruiting at 5 sites Biotech Healthcare Holding Gmbh · Düsseldorf, North Rhine-Westphalia and 5 other locations · NCT07232615

• Comparing surgery times for UNITY® VCS and CONSTELLATION® Vision System

  This study will see if the UNITY® VCS or the CONSTELLATION® Vision System leads to shorter combined cataract and vitrectomy (phacovitrectomy) surgery times for adults planned for 25‑gauge procedures.

  Recruiting Alcon Research · Manchester · NCT07228091

• Comparing corneal clarity and thickness after two cataract surgery systems

  This test will see if using a lower eye pressure with the Unity system during cataract surgery leads to fewer side effects and quicker vision recovery than using a higher pressure with the Centurion system for people having cataract surgery.

  Recruiting Metrolina Eye Associates, PLLC · Matthews, North Carolina · NCT07222150

• Bimatoprost implant with SpyGlass intraocular lens vs timolol drops for cataract patients with glaucoma

  This study tests whether placing a bimatoprost implant together with a SpyGlass intraocular lens during cataract surgery controls eye pressure better than daily timolol drops in people with mild to moderate open‑angle glaucoma or ocular hypertension.

  Recruiting Phase 3 SpyGlass Pharma, Inc. · San Antonio, Texas · NCT07218796

• Combining a bimatoprost eye implant with the SpyGlass intraocular lens versus timolol eye drops for people having cataract removal

  This study will test whether placing a small bimatoprost implant with the SpyGlass intraocular lens at the time of cataract surgery better controls eye pressure than using timolol eye drops in people with mild to moderate open-angle glaucoma or ocular hypertension.

  Recruiting Phase 3 SpyGlass Pharma, Inc. · Houston, Texas · NCT07218783

• Stem cell–fortified eye drops to improve tear stability and dry eye symptoms in people with cataract or dry eye

  This will test stem cell‑fortified eye drops to improve tear film stability, increase tear volume, and ease dry eye symptoms in adults with dry eye disease, including those with cataract.

  Recruiting Phase 4 Ace Cells Lab Limited · Giza · NCT07191847

• AI reading of IOLMaster 700 reports to recommend toric lenses and refractive targets

  This project tests whether large language models can read de-identified IOLMaster 700 report images to pull out eye measurements, recommend toric intraocular lenses, and predict postoperative refractions for people with cataract.

  Recruiting Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT07183891

• Vision after Clareon Vivity versus PureSee extended‑depth‑of‑focus lens implants

  This study will test whether two extended‑depth‑of‑focus intraocular lenses (Clareon Vivity and PureSee) give good vision for people aged 50 and older having cataract surgery in both eyes.

  Recruiting OMIQ Research · Sant Cugat del Vallès, Barcelona · NCT07165197

• Comparison of Lioli™, Pioli™, and Pioli™ Plus intraocular lens injectors

  This will test whether three different IOL injectors—Lioli™, Pioli™, and Pioli™ Plus—change corneal incision size or complication rates for people aged 40 and older having cataract surgery.

  Recruiting AST Products, Inc. · Seville, Sevilla · NCT07140029

• My Eyes, My Light — community eye screening in Char Fasson

  This project tests whether a community-based screening program can find treatable eye problems in people aged 35 and older who live in Char Fasson, Bangladesh.

  Recruiting Data Yakka, Inc. · Char Fasson, Bhola · NCT07135570

• Using a capsular tension ring to keep the lens implant centered in people with retinitis pigmentosa who need cataract surgery

  This trial will try adding a capsular tension ring to one eye of adults with retinitis pigmentosa undergoing cataract surgery to see if it keeps the implanted lens more centered and reduces vision problems compared with the other eye.

  Recruiting Zhongshan Ophthalmic Center, Sun Yat-sen University · Guangzhou, Guangdong and 2 other locations · NCT07126470

• Femtosecond laser arcuate keratotomy to reduce corneal astigmatism during cataract surgery

  This study will try using a computer-guided femtosecond laser cut (FSAK) during cataract surgery to reduce mild-to-moderate corneal astigmatism in adults aged 20–80.

  Recruiting Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT07081919

• Intranasal dexmedetomidine to stabilize blood pressure during cataract surgery in older adults

  This trial will test whether a single intranasal dose of dexmedetomidine given before cataract surgery helps control blood pressure in people aged 65 and older with hypertension.

  Recruiting Phase 3 Suez Canal University · Ismailia, Ismailia Governorate · NCT07080229

• Capsular tension ring to improve intraocular lens stability in people with high myopia and cataracts

  This test will see if placing a capsular tension ring in one eye during cataract surgery helps the artificial lens stay centered and gives better vision for people with high myopia, by comparing the treated eye to the other eye without the ring.

  Recruiting Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT07052825

• Vision screening in general practice to catch preventable sight loss in people over 70

  This project will test a GP-based vision-screening program for people aged 70 and older with at least one chronic condition to find sight problems early.

  Recruiting at 2 sites University of Copenhagen · Copenhagen, Capital Region and 1 other locations · NCT07015034

• Capella Scientia: developing Unity DX to measure eyes with cataract.

  This project will test whether the Unity DX device can reliably collect eye measurements (biometry and aberrometry) in adults with cataracts.

  Recruiting at 4 sites Alcon Research · Salt Lake City, Utah and 4 other locations · NCT06987474

• Tran cannula versus augmented irrigation during cataract surgery for pseudoexfoliative glaucoma

  This study will test whether using the single-use Tran cannula during cataract surgery lowers intraocular pressure more than increased irrigation for people with early-to-moderate pseudoexfoliative glaucoma.

  Recruiting Hôpital Privé de la Baie · Avranches and 2 other locations · NCT06979752

• Comparing femtosecond laser-assisted versus conventional cataract surgery for people with Fuchs endothelial corneal dystrophy

  This study will test whether femtosecond laser-assisted cataract surgery or conventional phacoemulsification better preserves corneal endothelial cells and vision in adults with moderate to severe Fuchs endothelial corneal dystrophy who need cataract surgery.

  Recruiting Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT06966167

• Comparing different intraocular lenses for cataract surgery

  This study is testing three different types of lenses used in cataract surgery to see which one helps people see better after the procedure.

  Recruiting at 2 sites Phase 4 Berkeley Eye Center · Plymouth Meeting, Pennsylvania and 1 other locations · NCT06922084

• Vivinex Impress XY1-EM versus RayOne EMV intraocular lenses for cataract

  This test compares two extended depth-of-vision intraocular lenses—the Vivinex Impress XY1-EM and the RayOne EMV—to see which gives better distance and intermediate vision after cataract surgery in adults with age-related bilateral cataracts.

  Recruiting Medical University of Bialystok · Bialystok, Polska · NCT06891092

• Comparing two microinvasive glaucoma surgeries with cataract surgery

  This study tests which of two new glaucoma surgeries, MINIject or Hydrus, works better when done with cataract surgery for people with chronic glaucoma.

  Recruiting Medical University of Graz · Graz, Styria · NCT06844292

• Comparing two devices for measuring eye parameters in cataract surgery

  This study is testing which of two devices is better at measuring eye parameters to help adults with cataracts get the best vision after surgery.

  Recruiting The Eye institute of Utah · Salt Lake City, Utah · NCT06801678

• Implanting functional intraocular lenses in patients with epiretinal membrane

  This study is testing whether a special type of eye lens can improve vision better than a standard lens for cataract patients with a specific eye condition.

  Recruiting at 2 sites Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality and 1 other locations · NCT06719739

• Cataract surgery using low pressure techniques for glaucoma patients

  This study is testing a new cataract surgery method using lower pressure to see if it helps glaucoma patients have safer and better outcomes.

  Recruiting Visionair Oogzorg · Geel · NCT06712758

• Comparing complication rates in cataract surgery with different pre-operative treatments

  This study tests if a new combination of eye treatments before cataract surgery can lower the risk of complications compared to standard care.

  Recruiting at 2 sites Phase 1/2 The Eye Centers of Racine and Kenosha · Venice, Florida and 1 other locations · NCT06681688

• Using artificial intelligence to improve cataract surgery outcomes for patients with high myopia

  This study is testing a new artificial intelligence tool to see if it can help improve cataract surgery results for patients with severe nearsightedness by providing better lens calculations.

  Recruiting Shanghai High Myopia Study Group · Shanghai, Shanghai Municipality · NCT06616506

• Evaluating Clareon PanOptix outcomes in cataract patients with prior myopic surgery

  This study is testing how well the Clareon PanOptix lenses work for people with cataracts who have had previous eye surgery to see if they improve vision after surgery.

  Recruiting Juliette Eye Institute Research Center · Albuquerque, New Mexico · NCT06555289

• Assessing the safety and performance of a new intraocular lens for cataract surgery

  This study is testing a new type of lens for cataract surgery to see if it improves vision better than a standard lens for people aged 50 and older.

  Recruiting at 3 sites Cutting Edge SAS · Marseille and 2 other locations · NCT06446817

• Exploring dry eye disease patterns after cataract surgery

  This study looks at how cataract surgery affects dry eye symptoms in patients aged 50 to 90 and tests if using artificial tears helps improve their comfort over time.

  Recruiting Lithuanian University of Health Sciences · Kaunas · NCT06298890

• Comparing two methods for calculating intraocular lens power during cataract surgery

  This study tests which method, using a special device during surgery or a formula before surgery, does a better job at calculating the right lens power for people getting cataract surgery.

  Recruiting Instituto de Oftalmología Fundación Conde de Valenciana · Mexico City, Cuauhtemoc · NCT06219252

• New multifunctional instruments for cataract surgery

  This study is testing new surgical tools for cataract surgery to see if they make the procedure easier and safer compared to the traditional tools.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06182605

• Safety assessment of the IC-8 Apthera IOL after cataract treatment

  This study is testing the safety of the IC-8 Apthera eye lens in people who have had cataract surgery and need treatment for a common complication called posterior capsule opacification.

  Recruiting at 14 sites Bausch & Lomb Incorporated · Dothan, Alabama and 13 other locations · NCT06060041

• Effects of Ripasudil on Patients with Fuchs' Endothelial Dystrophy Undergoing Cataract Surgery

  This study is testing if a new eye drop called ripasudil can help people with Fuchs' Endothelial Dystrophy have better results after cataract surgery.

  Recruiting Phase 3 Singapore Eye Research Institute · Singapore, Singapore · NCT06048380

• IOL with a Virtual Aperture for clearer near and distance vision after cataract surgery

  A device study tests whether a virtual aperture intraocular lens can help adults with cataracts see clearly at distances and near without glasses.

  Recruiting at 7 sites Z Optics, Inc. · Coimbra and 7 other locations · NCT05955846

• Lignocaine microneedle patch versus 5% EMLA patch for numbing the skin before blood draws in adults

  We will try a dissolvable maltose microneedle patch that delivers lignocaine to numb the skin before blood draws in adults having eye surgery and compare it with the standard 5% EMLA patch.

  Recruiting Phase 1/2 Universiti Kebangsaan Malaysia Medical Centre · Kuala Lumpur, Kuala Lumpur · NCT05694858

• Assessing the safety of EO2002 after cataract surgery

  This study is testing if a new treatment called EO2002 is safe for people who have just had cataract surgery.

  Recruiting Phase 1 Asociación para Evitar la Ceguera en México · Mexico City, Mexico City · NCT05587205

• Evaluating a new dropless approach for postoperative care after cataract surgery

  This study is testing a new way to care for patients after cataract surgery by using just one injection instead of multiple eye drops to see if it helps them recover better and stick to their treatment.

  Recruiting Phase 4 University of California, San Francisco · San Francisco, California · NCT05157113

• Combining endoscopic cyclophotocoagulation with cataract surgery for normal tension glaucoma

  This study is testing if adding a special eye treatment during cataract surgery can help people with normal tension glaucoma lower their eye pressure better than cataract surgery alone.

  Recruiting Helsinki University Central Hospital · Helsinki · NCT04651530

• Comparing iStent and laser treatment for exfoliation glaucoma during cataract surgery

  This study is testing whether using the iStent or laser treatment during cataract surgery helps people with exfoliation glaucoma see better compared to just having cataract surgery alone.

  Recruiting Helsinki University Central Hospital · Helsinki · NCT04635020

• Using advanced imaging technology during eye surgery

  This study is testing a new imaging technology during eye surgery to see if it can help doctors perform better and improve outcomes for patients with retinal diseases.

  Recruiting Duke University · Durham, North Carolina · NCT03713268

• Evaluating long-term visual outcomes after cataract surgery in high myopia patients

  This study looks at how cataract surgery affects vision over time in people with severe nearsightedness compared to those with regular age-related cataracts.

  Recruiting Shanghai High Myopia Study Group · Shanghai, Shanghai Municipality · NCT03062085

• Evaluating outcomes of cataract surgery

  This study looks at how well people can see after having cataract surgery to better understand the results of the procedure.

  Recruiting Evidence Based Cataract Study Group · Shanghai, Shanghai Municipality · NCT02182921

NIH-funded research (24)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How the aging lens affects vision and what we can do about it

  This grant studies how aging changes lens water and ion balance to cause cataracts and presbyopia, with the goal of better preserving vision for aging adults.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11524445

• Glutaredoxin and aging: how it affects cataracts and new treatment ideas

  A research project explores how aging affects the lens of the eye and tests new ways to prevent or treat cataracts by studying antioxidant repair and inflammation.

  NIH research University of North Texas Hlth Sci Ctr · Fort Worth, United States · NIH-11449438

• Cataracts and Work Exposures in Denmark

  A large Danish study will look at whether job-related exposures, both chemical and non-chemical, are linked to developing cataracts.

  NIH research University of North Texas · Denton, United States · NIH-11444890

• Tele-mentoring with an ultra-portable surgical microscope to treat cataracts in underserved communities

  A portable medical microscope with remote mentoring helps doctors in underserved areas perform cataract surgery more safely and effectively for people who need it.

  NIH research X-Biomedical, INC. · Newtown Square, United States · NIH-11408785

• Cataract Surgery and its Possible Impact on Alzheimer’s Disease and Related Dementias

  This project explores whether fixing vision through cataract surgery could influence the progression and onset of Alzheimer’s disease and related dementias.

  NIH research Stanford University · Stanford, United States · NIH-11392946

• Role of S100 Proteins in the Eye Lens and Cataract

  A study at Duke University will explore how S100 family proteins affect lens clarity and shape to understand why cataracts develop.

  NIH research Duke University · Durham, United States · NIH-11384546

• How alpha-crystallin and cholesterol affect cataract development

  This grant studies how a lens protein interacts with cholesterol in the eye to influence cataract formation, with the goal of understanding why lenses become cloudy as we age.

  NIH research Boise State University · Boise, United States · NIH-11365902

• PhacoTrainer: AI-powered feedback tool to help cataract surgery training

  A new AI-based tool analyzes cataract surgery videos to give trainees clear, objective feedback and track their skill development.

  NIH research Stanford University · Stanford, United States · NIH-11344728

• Understanding how aging affects lens fluids and cataracts

  We’re studying how aging changes the lens in the eye and contributes to cataracts, with findings that could help keep vision clearer as people get older.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11298036

• How the eye's lens affects measurements of eye length

  This project uses new, non-contact imaging to measure each person's lens refractive index and eye length to improve accuracy for things like myopia research and cataract surgery.

  NIH research New England College of Optometry · Boston, United States · NIH-11189681

• Understanding how a key protein interacts with eye lens membranes in cataract development

  This work explores how a protein called alpha-crystallin binds to eye lens membranes, which can lead to cataracts.

  NIH research Boise State University · Boise, United States · NIH-11179163

• Preventing Clouding After Cataract Surgery

  This research looks at why some people get cloudy vision again after cataract surgery, hoping to find ways to stop it.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11138695

• How S100 proteins affect the eye lens and cataracts

  This project looks at whether S100 proteins help keep the eye's lens clear and flexible for people with or at risk of cataracts.

  NIH research Duke University · Durham, United States · NIH-11138641

• Why some people get age-related cataracts and how to predict who is at risk

  This project looks for genetic differences and lifestyle factors that explain why some adults develop age-related cataracts to improve risk prediction.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11136900

• Cataract surgery and its effects on thinking, mild cognitive impairment, and dementia

  This project looks at whether cataract surgery helps people with or at risk for Alzheimer's disease or mild cognitive impairment keep their thinking skills longer.

  NIH research Stanford University · Stanford, United States · NIH-11115571

• Understanding how the eye's lens affects measurements for cataract surgery

  This study is looking at how the eye's lens affects measurements needed for cataract surgery and other treatments, and it's for anyone who wants better eye care; the researchers are working on a new, easy way to measure these important details to help improve surgery results and understand vision problems like nearsigh

  NIH research New England College of Optometry · Boston, United States · NIH-10987790

• Understanding how certain proteins affect lens clarity and cataract formation

  This study is looking at how certain proteins in the eye help keep the lens clear and strong, which is important for good vision, and it hopes to find new ways to prevent or treat cataracts that could help people like you.

  NIH research Duke University · Durham, United States · NIH-10893923

• Investigating how lens capsule changes lead to cataract surgery complications

  This study is looking at how certain proteins might cause vision problems after cataract surgery, with the goal of finding new ways to prevent or treat these issues for people who have had the surgery.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10891485

• Identifying eye structure changes in children after cataract surgery to predict glaucoma risk

  This study is looking at how certain features of the eye can help doctors figure out if kids who have had cataract surgery might be at risk for glaucoma, using special imaging technology to get a closer look at their eyes.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-10880646

• Understanding genetic and non-genetic factors that contribute to cataract risk

  This study is looking at how both genes and other health factors can increase the chances of getting age-related cataracts, which can lead to blindness, so we can find out who might be at risk and how to help prevent them.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-10875664

• Understanding how a protein interacts with cholesterol in the eye lens to cause cataracts

  This study is looking at how a protein called alpha-crystallin interacts with cholesterol in the eye lens, which could help us understand how cataracts form as we get older, with the hope of finding ways to prevent or even reverse them.

  NIH research Boise State University · Boise, United States · NIH-10862407

• Understanding how specific proteins in the eye lens interact with cell membranes as we age.

  This study is looking at how a special protein called alphaA-crystallin interacts with lens cells in our eyes, especially as we age and develop cataracts, to help find ways to prevent or slow down cataract formation.

  NIH research State University of New York at Albany · Albany, United States · NIH-10833663

• Developing new lenses for cataract surgery that resist cell growth

  This study is testing a new type of silicone lens for cataract surgery that aims to prevent common complications, like cloudy vision after surgery, so patients can have a better experience and possibly avoid extra surgeries.

  NIH research Texas Engineering Experiment Station · College Station, United States · NIH-10783729

• Understanding how a specific genetic change leads to age-related cataracts

  This study is looking at how certain changes in eye proteins can lead to cataracts as we get older, using a special mouse model to help us understand what happens in our eyes, so we can find better ways to prevent or treat cataracts.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10597653

Related topics

Quick answers

How many Cataract clinical trials are recruiting right now?

68, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 27 countries. The most sites are in United States (18 trials), China (16 trials), Spain (6 trials), Poland (4 trials), India (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 5, Phase 3: 4, Phase 1/2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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