Condition

Eye Diseases clinical trials and research

• 22Clinical trials
• 8NIH research projects
• 1New in 30 days
• 20Countries

Newest Eye Diseases clinical trials

All recruiting trials (22)

• ETHY-001 safety and activity in Thyroid Eye Disease (TED)

  This study tests ETHY-001 versus placebo to see if it is safe, tolerable, and shows activity in people with thyroid eye disease.

  Recruiting at 2 sites Phase 1 Ethyreal Bio, Inc. · Orland Park, Illinois and 2 other locations · NCT07885605

• Autologous Serum Tears with Hyaluronate vs Standard Serum Tears for Moderate-to-Severe Dry Eye

  This study tests whether adding sodium hyaluronate to autologous serum eye drops provides better relief for adults with moderate-to-severe dry eye in one eye, compared with the standard serum drops in the other eye.

  Recruiting Phase 2 University of Miami · Miami, Florida · NCT07413172

• Two approaches to repeat eyelid surgery for post-operative trichiasis

  This project will try whether the newer Bevel-Rotate Advancement Procedure (B-RAP) or the standard Bilamellar Tarsal Rotation (BLTR) gives better results for people in Tanzania who need repeat surgery for post-operative trachomatous trichiasis.

  Recruiting at 2 sites University of North Carolina, Chapel Hill · Chapel Hill, North Carolina and 1 other locations · NCT07322302

• How TRYPTYR affects quality of life and the ability to work for people with dry eye

  This one-month test will see if TRYPTYR (acoltremon) eye drops help adults with chronic dry eye produce more tears, reduce symptoms, and improve their ability to do work.

  Recruiting at 3 sites Phase 4 Southern College of Optometry · Pittsburg, Kansas and 2 other locations · NCT07266948

• Course of EYS-associated retinitis pigmentosa in adults from Russia and former CIS

  We will follow adults with pathogenic EYS gene variants from Russia and former CIS for four years to try to find reliable vision and retinal measures for future treatments.

  Recruiting Sensor Technology for Deafblind · Moscow · NCT07228793

• Dapagliflozin (an SGLT2 inhibitor) for slowing geographic atrophy in dry AMD

  This trial will test whether taking dapagliflozin once daily can slow the growth of geographic atrophy in people aged 50 and older with dry age-related macular degeneration.

  Recruiting Phase 2 Washington University School of Medicine · St Louis, Missouri · NCT07174687

• Michigan telemedicine screening for glaucoma and other sight‑threatening eye problems

  This program tests whether a technology-enhanced telemedicine screening finds glaucoma, diabetic eye disease, and visually significant cataracts more often than a standard optometric exam for patients at a community health center.

  Recruiting University of Michigan · Flint, Michigan · NCT06934577

• Sepofarsen injections for LCA10 due to the CEP290 p.Cys998X mutation

  This study will test whether sepofarsen eye injections can improve vision in children and adults with LCA10 caused by the CEP290 c.2991+1655A>G (p.Cys998X) mutation.

  Recruiting at 17 sites Phase 3 Laboratoires Thea · San Francisco, California and 17 other locations · NCT06891443

• Auto-aligning handheld OCT for adult and pediatric retinal imaging

  We will test a new handheld OCT device that automatically aligns to capture retinal images in healthy adults, adult eye patients, and children.

  Recruiting Duke University · Durham, North Carolina · NCT06841575

• Assessing patterns of eye diseases in patients at Sohag University Hospital

  This study looks at how common different eye diseases are among patients visiting the Eye Investigation Unit at Sohag University Hospital to see if there are any differences between men and women.

  Recruiting Sohag University · Sohag · NCT06812845

• Precision diagnosis and therapy for rare eye and neuromuscular diseases

  This study is testing new ways to find the genetic causes of rare eye and muscle diseases to help create more personalized treatments for patients.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06775561

• Using AI to identify eye and brain conditions from fundus photographs in emergency settings

  This study is testing whether artificial intelligence can help doctors quickly spot eye and brain problems from photos taken in emergency rooms to improve patient care.

  Recruiting Fondation Ophtalmologique Adolphe de Rothschild · Paris · NCT06643338

• Evaluating a stem cell treatment for geographic atrophy from dry age-related macular degeneration.

  This study is testing a new stem cell treatment for people with geographic atrophy from dry age-related macular degeneration to see if it can help improve their vision.

  Recruiting at 3 sites Phase 1/2 Eyestem Research Pvt. Ltd. · Jālna, Maharashtra and 2 other locations · NCT06394232

• Evaluating linsitinib for thyroid eye disease

  This study is testing if a new drug called linsitinib can help people with moderate to severe thyroid eye disease who haven't improved with other treatments.

  Recruiting at 2 sites Phase 2/3 Sling Therapeutics, Inc. · Miami, Florida and 1 other locations · NCT06112340

• Observational study on eye health in the elderly

  This study is looking at how lifestyle and genetics affect eye health in older people to help understand the risks for common eye diseases like glaucoma and macular degeneration.

  Recruiting Zhongshan Ophthalmic Center, Sun Yat-sen University · Guangzhou, Guangdong · NCT05851287

• Using stem cells from umbilical cords to treat non-arteritic ischemic optic neuropathy

  This study is testing if using stem cells from umbilical cords can help people with non-arteritic ischemic optic neuropathy improve their vision and overall eye health.

  Recruiting at 2 sites Phase 1 The Foundation for Orthopaedics and Regenerative Medicine · Naples, Florida and 1 other locations · NCT05147701

• Treatment for bleeding in the eye due to wet macular degeneration

  This study is testing if a new surgical treatment combined with injections can help older adults with bleeding in the eye from wet macular degeneration see better than the usual injections alone.

  Recruiting at 40 sites Phase 3 King's College Hospital NHS Trust · Bonn and 41 other locations · NCT04663750

• Using laser treatment to manage glaucoma in patients receiving a Boston keratoprosthesis

  This study is testing a laser treatment to see if it can help manage glaucoma in patients who have received an artificial cornea to improve their vision.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT04232982

• Comparing eye disease prevalence in diabetic and healthy children

  This study looks at how common eye diseases are in children with diabetes compared to healthy kids to help improve eye care for those with diabetes.

  Recruiting Shanghai Eye Disease Prevention and Treatment Center · Shanghai, Shanghai Municipality · NCT03587948

• A comprehensive registry for eye diseases

  This study is creating a national database to help eye doctors track and improve the care they provide to patients with eye diseases.

  Recruiting American Academy of Ophthalmology · San Francisco, California · NCT02485847

• Using adaptive optics to improve retinal imaging

  This study is testing whether a new imaging technique can help doctors take better pictures of the retina to improve diagnosis and treatment for people with eye diseases.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02317328

• Screening for participants with eye diseases

  This study is looking for people with eye diseases to see if they can join other research studies and to collect samples for future eye disease research.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00655096

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Biobank tools to better understand and manage eye diseases

  A study to connect eye disease genetics with real-world health data to improve understanding and care for eye conditions.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11513632

• Telehealth glaucoma screening for high-risk patients

  A new telemedicine program will check for glaucoma in Black and Latino people at community clinics to catch and manage eye disease early.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11358977

• Improving imaging and treatments for the retina, RPE, and choroid in macular degeneration

  Researchers are developing high-resolution live imaging and targeted approaches to track and treat changes in the retina, retinal pigment epithelium, and choroid that lead to inherited and age-related macular degeneration.

  NIH research University of California at Davis · Davis, United States · NIH-11303434

• Long-term safety and vision outcomes after immune-suppressing treatment for eye inflammation

  This project looks at long-term health, cancer risk, and vision outcomes in people who received systemic immune-suppressing drugs for non-infectious eye inflammation.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11204063

• New ways to use telehealth for finding and managing glaucoma and other serious eye conditions in people at higher risk

  This project explores if using telemedicine can help find glaucoma and other serious eye problems earlier in Black and Latino individuals and those with limited access to eye care.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11174193

• Improving understanding and management of eye diseases using biobank data

  This study is looking at how your genes might be linked to eye diseases, especially for people of African descent, by combining genetic information with health records to help doctors better understand and manage these conditions.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11171775

• Using telehealth to detect and manage glaucoma in high-risk groups

  This study is looking at how well telemedicine can help find glaucoma and other eye problems early in Black and Latino communities that may not have easy access to eye care, and it’s inviting people to take part in this important research.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11030179

• Investigating a new model for understanding eye development disorders

  This study is exploring how problems in eye development can lead to vision issues, and it's for anyone interested in understanding eye disorders better; researchers are creating a new model using special stem cells to see how different genes affect the way our eyes form, which could help in finding new treatments.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-10833658

Related topics

Quick answers

How many Eye Diseases clinical trials are recruiting right now?

22, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (13 trials), France (2 trials), China (2 trials), Canada (2 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 2: 2, Phase 3: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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