Investigating oral semaglutide for treating open-angle glaucoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of oral semaglutide in improving inner retinal function in patients diagnosed with open-angle glaucoma. Participants will be randomly assigned to receive either oral semaglutide or a placebo daily for six months. The primary outcome will be measured through the photopic negative response of the electroretinogram, with participants visiting the clinic five times for assessments throughout the study period. The trial seeks to determine if semaglutide can provide a new treatment option for this condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ability to read and speak Danish
* 45 years or older at the time of inclusion
* Visual acuity equal to or above 0.5 in the study eye
* Diagnosis of POAG with MD ≤ 16 dB with repeatable and reliable (false positive less than 15 %) VF loss measured by standard automated perimetry on at least one eye
* Receiving IOP-lowering glaucoma treatment
* Nerve fiber layer defects identified by OCT

Exclusion Criteria:

* Diabetes or renal impairment
* Medical history of significant eye disease (including ocular trauma) other than glaucoma
* Ocular inflammation/infection within three months from inclusion
* Intraocular surgery 3 months before inclusion
* Smoker at the time of inclusion
* Pregnant or breast-feeding
* Females of childbearing potential who are not using adequate contraceptive, which includes the following: Combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation: oral, intravaginal, or transdermal, progestogen-only hormonal contraception associated with inhibition of ovulation: oral, injectable, or implantable; Intrauterine device (IUD); Intrauterine hormone-releasing system (IUS); Bilateral tubal occlusion; Vasectomised partner; Sexual abstinence
* Subjects allergic to drug ingredients administered during the trial
* Subjects with untreated severe systemic disease or malignancies
* Previous history of pancreatitis
* BMI \< 18.5
* Subjects receiving treatment with: Dipeptidyl peptidase-4 inhibitors; Other GLP-1RAs; Insulin; Insulin analogues; Sulfonylurea; Systemic corticosteroids; Immunosuppressants

Where it's running

• Department of Ophthalmology, Rigshospitalet
  Glostrup Municipality, Denmark Recruiting

Study contacts

• Study coordinator: Miriam Kolko, MD, PhD
• Email: miriamk@sund.ku.dk
• Phone: +45 29807667

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.