Improving vision in glaucoma patients using electrical stimulation and learning techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of perceptual learning and transcranial electrical stimulation (tES) on enhancing visual function in patients with glaucoma. Participants will be randomly assigned to one of three groups: receiving either real or sham perceptual learning combined with either real or sham tES. The study involves a series of assessments and interventions over multiple visits to evaluate improvements in visual quality and functional performance. The goal is to determine if these combined approaches can effectively enhance vision in individuals suffering from peripheral field loss due to glaucoma.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age range from 18 to 80 years;
* Diagnosis of primary open angle or normal tension glaucoma with relative scotoma in both eyes;
* A relative scotoma defined as a Humphrey Field Analyser (HFA) threshold perimetry loss (mean deviation of -6dB) within the central 24 degree of the visual field for at least one eye;
* Best-corrected distance visual acuity of 6/12 or better (equivalent to 0.3 logMAR acuity or better to confirm that participant's central vision is preserved).
* Stable vision and visual field loss for at least 3 months;
* With a cognitive functional score of 22 or above in the Montreal Cognitive Assessment - Hong Kong version (HK-MoCA) (to confirm participant's intact cognitive function).

Exclusion Criteria:

* Ocular diseases other than glaucoma (e.g. age-related macular degeneration, diabetic retinopathy, moderate to severe cataract) or severe hearing impairment (to ensure that participant can hear the instructions clearly during assessments and training);
* Severe medical problems (e.g. stroke, Parkinson's disease) or self-reported neurological (e.g. brain surgery, brain tumor, peripheral neuropathy), or cognitive disorders (e.g. diagnosed dementia or cognitive impairment);
* Self-reported vestibular or cerebellar dysfunction, history of vertigo;
* Using any medications for any neurological conditions or psychiatric drugs (e.g. sedative, hypnotic) that might interfere motor control;
* Contraindications for non-invasive brain stimulation.

Where it's running

• The Hong Kong Polytechnic University
  Hong Kong, Hong Kong Recruiting

Study contacts

• Study coordinator: Allen Cheong, PhD
• Email: allen.my.cheong@polyu.edu.hk
• Phone: 852-27666108

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.