Condition

Open Angle Glaucoma clinical trials and research

• 10Clinical trials
• 11NIH research projects
• 9Countries

Newest Open Angle Glaucoma clinical trials

All recruiting trials (10)

• Rocklatan versus latanoprost for 24-hour eye pressure control in open-angle glaucoma and ocular hypertension

  This trial tests whether a combination eye drop (Rocklatan) lowers eye pressure over 24 hours more than latanoprost alone in adults with open-angle glaucoma or ocular hypertension.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT07325240

• Patient quality of life after different glaucoma surgeries

  This project uses the NEI-VFQ-25 vision questionnaire to see if adults who have PreserFlo MicroShunt, trabeculectomy, or non-penetrating deep sclerectomy report different quality of life after surgery.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07303257

• iStent infinite plus iDose TR for moderate-to-severe open-angle glaucoma

  This trial will see if placing an iStent infinite device together with an iDose TR travoprost implant can lower eye pressure and reduce glaucoma eye drops for people with moderate to severe open-angle glaucoma not controlled by medication or laser.

  Recruiting Phase 4 Wills Eye · Philadelphia, Pennsylvania · NCT07228221

• Eye-surface inflammation after replacing nightly preserved glaucoma drops with a Durysta implant

  We will try a single Durysta intracameral implant to see if cutting back nightly preserved glaucoma drops reduces eye-surface inflammation in people with open-angle glaucoma or ocular hypertension who are pseudophakic and have signs of surface damage.

  Recruiting Phase 4 University of Miami · Miami, Florida · NCT07217678

• Evaluating the effectiveness of surgical systems for treating open-angle glaucoma

  This study looks at how well a combination of surgical treatments can lower eye pressure in people with open-angle glaucoma over three years.

  Recruiting Barnet Dulaney Perkins Eye Centers · Mesa, Arizona · NCT06953349

• Vitamin mix for glaucoma patients

  This study is testing if a mix of certain vitamins can help protect the eyes and slow vision loss in people with glaucoma.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County and 1 other locations · NCT06885827

• Comparing the effectiveness of two glaucoma treatments

  This study is testing whether two new glaucoma treatments, Simbrinza and Rocklatan, work better than the current options, Cosopt and Latanoprost, for adults with mild to moderate open-angle glaucoma.

  Recruiting Phase 4 Prairie Eye Center · Springfield, Illinois · NCT06883123

• Investigating oral semaglutide for treating open-angle glaucoma

  This study is testing if a daily pill called semaglutide can help improve vision in people with open-angle glaucoma.

  Recruiting Phase 4 Glostrup University Hospital, Copenhagen · Glostrup Municipality · NCT06792422

• Predicting success of glaucoma surgery using trabeculopuncture

  This study is testing a new non-invasive method to see if it can help predict how well glaucoma surgery will work for patients who still have high eye pressure despite treatment.

  Recruiting Wuerzburg University Hospital · Würzburg, Bavaria · NCT06523751

• Comparing ELIOS with other devices for glaucoma patients undergoing cataract surgery

  This study is testing whether the ELIOS device can safely lower eye pressure better than another device for people with mild to moderate glaucoma who are having cataract surgery.

  Recruiting at 16 sites Elios Vision, Inc. · Leuven and 15 other locations · NCT06246136

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Gene therapy to normalize eye pressure in juvenile glaucoma

  A first-in-class gene therapy using a safe viral vector is being explored to normalize eye pressure in children and adults with juvenile open-angle glaucoma.

  NIH research Diorasis Therapeutics Corporation · Watertown, UNITED STATES · NIH-11409527

• Improving glaucoma risk predictions using diverse genetic data

  A glaucoma study uses genetic data from people of African, American, and European ancestry to build better risk scores and help with early detection.

  NIH research East Carolina University · Greenville, United States · NIH-11386975

• Multimodal AI to predict glaucoma progression and guide care

  A big-data AI tool uses eye images, scans, field tests, and health info to help predict who with open-angle glaucoma is at higher risk of vision loss so doctors can act sooner.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11365407

• Repairing the eye's drainage support to lower pressure in steroid-related and open-angle glaucoma

  This work tests whether reversing changes in the support tissue around drainage cells can help lower eye pressure for people with steroid-induced high eye pressure and open-angle glaucoma.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11302646

• Replacing damaged eye drainage cells to treat glaucoma

  This project is developing a cell-based treatment to replace lost drainage cells and help people with primary open-angle glaucoma keep eye pressure lower and protect vision.

  NIH research Iowa City VA Medical Center · Iowa City, United States · NIH-11175341

• Understanding how steroid exposure affects eye pressure and glaucoma

  This study is looking at how changes in the eye's structure can raise pressure inside the eye, which is a problem for people with open angle glaucoma, and it’s exploring whether a treatment called tPA can help lower that pressure and improve care for patients.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11028857

• Improving risk prediction for glaucoma in diverse populations

  This study is looking to improve how we predict the risk of primary open-angle glaucoma in people of African ancestry, so that they can get better early diagnosis and treatment options based on their unique genetic background.

  NIH research East Carolina University · Greenville, United States · NIH-11002782

• Using cell therapy to treat primary open angle glaucoma

  This study is testing a new cell therapy to help people with primary open angle glaucoma by using special stem cells to improve eye function and lower pressure, which could help prevent vision loss when regular treatments aren't enough.

  NIH research Iowa City VA Medical Center · Iowa City, United States · NIH-10995780

• Better genetic risk prediction for open-angle glaucoma

  This project will build more accurate genetic risk tools for people at risk of open-angle glaucoma by including more diverse ancestry groups in the analysis.

  NIH research East Carolina University · Greenville, United States · NIH-10879124

• Evaluating treatments for open-angle glaucoma in diverse patient populations

  This study is looking at how well a special laser treatment works compared to eye drops for people with open-angle glaucoma, and it's open to a diverse group of patients to make sure the results reflect everyone.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10867985

• Improving fairness in glaucoma risk estimation using artificial intelligence

  This study is working on a new AI tool to help better predict the risk of glaucoma, especially for people in diverse communities like African and Hispanic Americans, so that everyone can get fairer and more accurate eye care.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-10726928

Related topics

Quick answers

How many Open Angle Glaucoma clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (5 trials), France (2 trials), Germany (2 trials), Belgium (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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