Eye drops Rhopressa vs Timolol to protect nerve cells in glaucoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, investigator-mmasked, crossover pilot trial comparing netarsudil (Rhopressa) and timolol in adults with open-angle glaucoma. Participants will use each medication for six months in random order, with regular visits to measure intraocular pressure and retinal structure. High-resolution AO-OCT imaging will track individual retinal ganglion cell layer changes over time to see if Rhopressa offers neuroprotection beyond pressure lowering. The study aims to determine if Rhopressa can reduce ganglion cell loss while maintaining similar IOP reduction to Timolol.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All subjects will be 18 years of age or older
* Subjects must be diagnosed with open-angle glaucoma and have had an eye exam within the past year
* Subjects with glaucoma will have structural (optic nerve and retinal nerve fiber layer) and functional (visual field testing) defects consistent with the diagnosis of glaucoma
* Subjects will have a corrected acuity of 20/50 or better and be able to fixate
* Naïve to medication subjects or post washout IOP between 18 and 34 mmHg
* Spherical equivalent from +3 diopters to -6 diopters, with a cylinder of \<-3 diopters
* Subject is willing and able to comply with the protocol requirements and to remain in the study for its full duration, including all scheduled visits and follow-up assessments

Exclusion Criteria:

* Subjects with a known intolerance to netarsudil ophthalmic solution
* Subjects with a known intolerance to, or contraindication for, timolol maleate
* Any subject whom the investigator determines to be at unacceptable risk for the washout or believes is unlikely to complete the study
* Subjects with retinal disease or optic neuropathies other than glaucoma that, in the opinion of the investigator, could confound the study assessments or outcome
* Female subjects who are pregnant, breastfeeding, or of childbearing age who are not sterile or using an acceptable method of contraception during the study

Where it's running

• Indiana University School Of Optometry
  Bloomington, Indiana, United States Recruiting

Study contacts

• Study coordinator: Brett J King, OD, FAAO, Dipl AAO (Glaucoma)
• Email: kingbrj@iu.edu
• Phone: (812) 855-1344

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.