Investigating inflammatory markers in glaucoma after corneal transplantation
Official title: Uncovering Inflammatory Mediators of Glaucoma Pathogenesis After Corneal Transplantation in Aqueous Humor and Tears
Run by Centre hospitalier de l'Université de Montréal (CHUM) · NCT04339907 · Data updated 2026-11-12
This study is trying to find out if certain markers in the tears and eye fluid of people who have had corneal transplants can help spot early signs of glaucoma.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Centre hospitalier de l'Université de Montréal (CHUM) Academic / other |
| Locations | 1 site (Montreal, Quebec) |
| Status | Recruiting |
| Started | May 11, 2020 |
| Main results expected | October 2028 |
| Study ends | May 2029 |
| Registry record updated | October 23, 2026 |
| Trial ID | NCT04339907 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with specific ocular conditions related to glaucoma and corneal transplantation.
✕Probably not a fit
Patients under 18 or those with ocular diseases not specified in the study criteria may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore the role of inflammatory mediators in the aqueous humor and tears of patients who have undergone corneal transplantation, particularly focusing on those with glaucoma. By sampling these fluids, researchers hope to identify potential biomarkers that could indicate early signs of glaucoma development or progression. The study includes various patient groups, including those with and without glaucoma, and those who have had different types of corneal surgeries. The ultimate goal is to better understand the mechanisms behind glaucoma in these patients and improve treatment strategies.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection and better management of glaucoma in patients who have undergone corneal transplantation.
How similar studies have gone: While the specific approach of using inflammatory biomarkers in this context may be novel, similar studies have shown promise in understanding glaucoma and its progression.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 years old or older * Informed consent * Ability to be followed for the duration of the study * Presence of ocular disease specified for each group Specific criteria for each group: * Group 1 : have no glaucoma and no systemic diseases * Group 2 : need to have glaucoma filtration surgery without prior corneal transplantation * Group 3 : need to have corneal transplantation (penetrating keratoplasty or Boston keratoprosthesis), with or without glaucoma * Group 4 : need to have intraocular surgery after prior corneal transplantation (penetrating keratoplasty or Boston keratoprosthesis) * Group 5 : need to have glaucoma filtration surgery with prior corneal transplantation (penetrating keratoplasty or Boston keratoprosthesis) Exclusion Criteria: * Aged less than 18 * Inability to give informed consent * Presence of ocular diseases other than those studied herein
Where it's running
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Centre Hospitalier de l'Université de Montréal (CHUM)
Montreal, Quebec, Canada Recruiting
Study contacts
- Principal investigator: Younes Agoumi, MD — Centre hospitalier de l'Université de Montréal (CHUM)
- Study coordinator: Marie-Catherine Tessier, M.Sc.
- Email: marie-catherine.tessier.chum@ssss.gouv.qc.ca
- Phone: 1-514-890-8000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.