Condition

Ocular Hypertension clinical trials and research

• 18Clinical trials
• 12NIH research projects
• 8Countries

Newest Ocular Hypertension clinical trials

All recruiting trials (18)

• TFC-003: a new eye drop combo for open-angle glaucoma and ocular hypertension

  This study tests whether TFC-003, alone or in slight revisions, can safely lower eye pressure in adults with open-angle glaucoma or ocular hypertension who aren’t yet at their target pressure.

  Recruiting Phase 3 Kukje Pharma · Seongnam · NCT07662759

• Imaging the effect of Netarsudil on the eye’s drainage system in glaucoma and ocular hypertension

  This study tests whether netarsudil eye drops change the trabecular meshwork’s structure compared with placebo in adults with ocular hypertension or open-angle glaucoma.

  Recruiting Phase 4 Indiana University · Bloomington, Indiana · NCT07588152

• Direct Selective Laser Trabeculoplasty to reduce glaucoma medications

  This study will try Direct Selective Laser Trabeculoplasty (DSLT) to reduce the number of eye-drop medications in adults with medically controlled primary open-angle glaucoma or ocular hypertension.

  Recruiting The Eye Institute of West Florida · Largo, Florida · NCT07390890

• HUC3-637 for primary open-angle glaucoma and ocular hypertension

  This study tests whether HUC3-637 is safe and can lower eye pressure in adults with primary open-angle glaucoma or ocular hypertension.

  Recruiting Phase 3 Huons Co., Ltd. · Seoul · NCT07335211

• Rocklatan versus latanoprost for 24-hour eye pressure control in open-angle glaucoma and ocular hypertension

  This trial tests whether a combination eye drop (Rocklatan) lowers eye pressure over 24 hours more than latanoprost alone in adults with open-angle glaucoma or ocular hypertension.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT07325240

• Bimatoprost implant with SpyGlass intraocular lens vs timolol drops for cataract patients with glaucoma

  This study tests whether placing a bimatoprost implant together with a SpyGlass intraocular lens during cataract surgery controls eye pressure better than daily timolol drops in people with mild to moderate open‑angle glaucoma or ocular hypertension.

  Recruiting Phase 3 SpyGlass Pharma, Inc. · San Antonio, Texas · NCT07218796

• Combining a bimatoprost eye implant with the SpyGlass intraocular lens versus timolol eye drops for people having cataract removal

  This study will test whether placing a small bimatoprost implant with the SpyGlass intraocular lens at the time of cataract surgery better controls eye pressure than using timolol eye drops in people with mild to moderate open-angle glaucoma or ocular hypertension.

  Recruiting Phase 3 SpyGlass Pharma, Inc. · Houston, Texas · NCT07218783

• Eye-surface inflammation after replacing nightly preserved glaucoma drops with a Durysta implant

  We will try a single Durysta intracameral implant to see if cutting back nightly preserved glaucoma drops reduces eye-surface inflammation in people with open-angle glaucoma or ocular hypertension who are pseudophakic and have signs of surface damage.

  Recruiting Phase 4 University of Miami · Miami, Florida · NCT07217678

• Limbal function and tear protein changes in glaucoma

  This study tests whether glaucoma and long-term glaucoma medicines change limbal stem cell–related corneal epithelial thickness and tear proteins in people with glaucoma, ocular hypertension, or healthy adults.

  Recruiting National Taiwan University Hospital · Hsinchu · NCT07119580

• Sustained-release TimoD (timolol) implant placed during cataract surgery for glaucoma or ocular hypertension

  This trial tests whether a small TimoD timolol implant placed during cataract surgery is safe and well tolerated in people with glaucoma or ocular hypertension.

  Recruiting Phase 1/2 EyeD Pharma · Panama City · NCT07036510

• Evaluating the long-term safety and effectiveness of a modified silicone tube for glaucoma treatment

  This study is testing a new silicone tube to see if it safely helps people with glaucoma manage their eye pressure and maintain good vision over the long term.

  Recruiting Davinci LTD · Tbilisi · NCT06691555

• AI-based glaucoma and eye disease screening at federally qualified health centers

  This project will test whether an AI-assisted eye screening program at federally qualified health centers can find glaucoma and other eye problems (like diabetic retinopathy and cataracts) and whether people follow up with an eye doctor.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06629649

• Nanodropper microdrop delivery for primary open-angle glaucoma and ocular hypertension

  This test will see if Nanodropper microdrops of glaucoma medicines lower eye pressure as well as standard eye drops for adults with primary open-angle glaucoma or ocular hypertension.

  Recruiting 59th Medical Wing · Lackland Air Force Base, Texas · NCT05844384

• Comparing two eye drops for treating glaucoma and ocular hypertension

  This study is testing if a new eye drop is just as effective as a standard one for treating glaucoma and high eye pressure in people who have these conditions.

  Recruiting at 8 sites Phase 3 Amneal Pharmaceuticals, LLC · Newport Beach, California and 8 other locations · NCT05401357

• Comparing the effects of two types of eye drops on eye health

  This study tests whether eye drops with preservatives or preservative-free eye drops are better for eye health in people with glaucoma or high eye pressure.

  Recruiting Phase 4 Copenhagen University Hospital, Rigshospitalet · Glostrup Municipality, Danmark and 1 other locations · NCT04957329

• Rocklatan vs latanoprost for ocular blood flow in ocular hypertension and suspected glaucoma

  This study tests whether adding netarsudil to latanoprost improves episcleral venous blood flow more than latanoprost alone in adults with ocular hypertension or suspected glaucoma.

  Recruiting at 4 sites Phase 4 University of Maryland, Baltimore · Baltimore, Maryland and 3 other locations · NCT04401982

• Continuous intraocular pressure monitoring with a sensing contact lens versus standard tonometry

  This trial tests a smart contact lens that continuously measures eye pressure and compares its readings to standard tonometry in people with glaucoma or ocular hypertension.

  Recruiting Sensimed AG · Lausanne, Canton of Vaud · NCT04024293

• Exploring blood flow and nerve health in glaucoma patients and healthy individuals

  This study is trying to see how blood flow affects nerve health in people with glaucoma compared to healthy individuals to find ways to protect vision.

  Recruiting Medical University of Vienna · Vienna · NCT03870230

NIH-funded research (12)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeted eye medicine to protect vision in glaucoma and steroid-induced glaucoma

  A new eyedrop medicine that blocks a protein (Grp94) to improve fluid drainage in the eye and lower eye pressure in glaucoma patients.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11370682

• Genomics of eye pressure and glaucoma risk

  This NIH grant funds a short-term study to understand the genetic and cellular reasons behind high eye pressure and glaucoma, with potential to inform future treatments for people at risk.

  NIH research Tufts Medical Center · Boston, United States · NIH-11355841

• How sudden eye pressure affects the optic nerve head

  This project measures how a sudden rise in eye pressure changes cells and tissues at the back of the eye to help people with glaucoma.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11307283

• Repairing the eye's drainage support to lower pressure in steroid-related and open-angle glaucoma

  This work tests whether reversing changes in the support tissue around drainage cells can help lower eye pressure for people with steroid-induced high eye pressure and open-angle glaucoma.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11302646

• New Treatments for Ocular Hypertension and Glaucoma

  This project is working to find new eye drop treatments for glaucoma by targeting a specific protein that causes pressure buildup in the eye.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11127496

• Understanding how sudden eye pressure changes affect the optic nerve in living human eyes

  This NIH grant tests how acute increases in eye pressure deform the optic nerve head in living human eyes to understand how this stress might lead to vision loss.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11099664

• Understanding how steroid exposure affects eye pressure and glaucoma

  This study is looking at how changes in the eye's structure can raise pressure inside the eye, which is a problem for people with open angle glaucoma, and it’s exploring whether a treatment called tPA can help lower that pressure and improve care for patients.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11028857

• Investigating how glucocorticoids affect eye pressure and glaucoma risk

  This study is looking at how certain medications for inflammation can raise eye pressure and increase the risk of glaucoma in some people, and it aims to find out if genetics play a role in who might be more affected, so we can help keep those at risk safer.

  NIH research University of North Texas Hlth Sci Ctr · Fort Worth, United States · NIH-10914820

• Targeting a specific protein to treat eye pressure and glaucoma

  This study is looking at how a protein called Grp94 affects eye pressure and glaucoma, and it aims to find new treatments that could help people with these conditions by reducing harmful protein buildup in the eye.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-10859324

• Understanding long-term quality of life for people with ocular hypertension

  This study is looking at how different treatments and other factors affect the quality of life related to vision for people with ocular hypertension over 20 years, so if you have this condition, your experiences and feedback can help us understand how it impacts daily life and how it might change if you develop glaucom

  NIH research Washington University · Saint Louis, United States · NIH-10837803

• Investigating the role of a specific microRNA in eye pressure regulation related to glaucoma.

  This study is looking at how a tiny molecule called miR-182-5p affects eye pressure in people with primary open-angle glaucoma, hoping to find new ways to help manage the condition by comparing its levels in the fluid of affected eyes to those in healthy ones.

  NIH research Augusta University · Augusta, United States · NIH-10770536

• Understanding how glucocorticoids can cause increased eye pressure

  This study is looking at how certain eye injections can cause high pressure in the eyes, which might lead to vision problems, and it aims to find out if some people are more at risk because of their genes, so we can better understand and treat this issue for patients.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-10755718

Related topics

Quick answers

How many Ocular Hypertension clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (10 trials), South Korea (2 trials), Austria (1 trial), Panama (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 5, Phase 4: 5, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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