Comparing cytokine levels in eye fluids before and after a specific glaucoma treatment
Comparison of Cytokines Profile in Aqueous Humor and Tear Before and After UCP Treatment
Zhongshan Ophthalmic Center, Sun Yat-sen University · NCT06243497
This study is testing how a glaucoma treatment called Ultrasound Cyclo Plasty affects certain proteins in the eye fluids of patients to see if it helps manage their condition better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Sex | All |
| Sponsor | Zhongshan Ophthalmic Center, Sun Yat-sen University (other) |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT06243497 on ClinicalTrials.gov |
What this trial studies
This observational study aims to compare the profiles of cytokines in the aqueous humor and tears of patients diagnosed with glaucoma before and after undergoing Ultrasound Cyclo Plasty (UCP). UCP is a minimally invasive technique that targets the ciliary body to manage intraocular pressure (IOP), which is crucial for glaucoma treatment. By analyzing the changes in cytokine levels, the study seeks to understand the pathophysiological changes associated with glaucoma and the effectiveness of UCP. The findings could provide insights into potential biomarkers for glaucoma management.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with glaucoma who have elevated intraocular pressure or progressive optic nerve damage.
Not a fit: Patients with other eye diseases affecting intraocular pressure or those who have had recent anti-glaucoma surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of glaucoma treatment and lead to improved management strategies for patients.
How similar studies have performed: Previous studies have shown promising results in understanding the role of cytokines in glaucoma, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The patient was definitely diagnosed as glaucoma, No age or gender limitation, IOP(intraocular pressure) ≥ 21mmHg under the maximum tolerated dose of antiglaucoma medication, or IOP \< 21mmHg and glaucomatous optic nerve damage progressed. Exclusion Criteria: * Other eye diseases that could affect IOP; preoperative use of systemic steroid drugs; history of other anti-glaucoma surgery within 3 months; ocular infection 2 weeks prior to UCP
Where this trial is running
Guangzhou, Guangdong
- Zhognshan Ophthalmic Center, Sun Yat-sen University — Guangzhou, Guangdong, China (RECRUITING)
Study contacts
- Study coordinator: HuanYang Shi, M.D
- Email: shyhuanyang@163.com
- Phone: +8602066615461
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Glaucoma, Ultrasound Cyclo Plasty, Aqueous Humor, Tear, Cytokines