NIH-funded research R01 grant

Novel glaucoma diagnostics using 3-D imaging and AI

Official title: Novel Glaucoma Diagnostics for Structure and Function.

Funded at Wills Eye Health System · NIH-11418896 · Data updated 2026-11-12

A research project aims to improve early detection and tracking of glaucoma by combining 3-D eye imaging with artificial intelligence.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionWills Eye Health System
NIH-funded
Lab location1 site (Philadelphia, United States)
Project startAugust 1, 2000
Project endJuly 31, 2029
Funding year2026
Award (this year)$1,232,538
NIH project number5R01EY013178-27
Project IDNIH-11418896 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates include adults suspected of or diagnosed with glaucoma who undergo ocular imaging as part of their care.

Less likely to help

Patients not undergoing ocular imaging or with conditions outside glaucoma may not benefit directly.

What this research studies

If you have glaucoma or are at risk, this project uses advanced 3-D imaging and AI to detect the disease early and to better predict how it will progress. Researchers will analyze OCT images with new processing methods to reduce variability and make results more reliable across different devices. The goal is to give doctors clearer, personalized information to guide treatment. This work builds on existing eye-imaging expertise to harmonize data and improve clinical decision-making.

Why it matters

Potential benefit: If successful, patients could get earlier, more accurate diagnosis and more tailored treatment plans to preserve vision.

How similar studies have gone: Previous work shows that 3-D imaging and AI can improve detection and monitoring, but device differences and variability remain challenges.

Where this research is happening

  • Wills Eye Health System
    Philadelphia, United States
    Active

Researchers

  • Principal investigator: Schuman, Joel S — Wills Eye Health System
  • Study coordinator: Schuman, Joel S

Related research

Other NIH-funded projects on the same topics.

  • IOP and CSF Pressure in Glaucoma Risk

    This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11644421

  • Comparing tube positions in glaucoma implants to protect corneal cells

    This trial compares two tube placements for glaucoma drainage implants to see which better protects corneal cells and controls eye pressure in people with uncontrolled glaucoma.

    NIH research University of California, San Francisco · San Francisco, United States · NIH-11520347

  • Automated topographic test for glaucoma detection and progression

    A new automated method uses topographic structure-function mapping to help diagnose glaucoma earlier and track its progression in patients.

    NIH research Columbia University Health Sciences · New York, United States · NIH-11516608

  • Using AI on eye scans and genes to predict glaucoma risk

    This project uses artificial intelligence on eye scans, vision tests, and genetic information to find people most likely to develop or have worsening glaucoma.

    NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11469603

  • AI-based glaucoma screening in community health centers

    A new, easy-to-use AI screening approach will be tested in federally funded health centers to help identify people at risk for glaucoma, especially in communities with higher risk.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11454104

  • Understanding how glaucoma genes control eye cell function

    A long-term research project will study how genetic factors affect eye cells in adults with glaucoma to uncover new ideas for protecting vision.

    NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11450761

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.