NIH-funded research R01 grant

AI-powered eye scans to detect glaucoma earlier and more accurately

Official title: Functional and Structural Optical Coherence Tomography for Glaucoma

Funded at Oregon Health & Science University · NIH-11448822 · Data updated 2026-11-12

A new project uses advanced eye imaging and artificial intelligence to measure a tiny retina layer more precisely, helping detect glaucoma earlier for patients.

More Glaucoma research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionOregon Health & Science University
NIH-funded
Lab location1 site (Portland, United States)
Project startSeptember 30, 2013
Project endMay 31, 2030
Funding year2026
Award (this year)$659,136
NIH project number2R01EY023285-14
Project IDNIH-11448822 on NIH RePORTER

Who could benefit from this research

Could help

Adults at risk for or with glaucoma who undergo OCT imaging as part of their eye care.

Less likely to help

People without glaucoma or who do not undergo OCT imaging would not directly benefit.

What this research studies

Glaucoma commonly causes vision loss, and current tests can miss early changes or give inconsistent results. This project will use ultrahigh-resolution OCT images and AI to improve measuring the macular ganglion cell layer, which may reveal issues sooner. By refining how images are analyzed, doctors could detect progression more reliably and tailor treatments to each patient. The work involves developing AI models that work with both high- and standard-resolution scans to improve accuracy across disease stages.

Why it matters

Potential benefit: If successful, patients could receive earlier and more accurate detection of glaucoma progression, leading to better-preserved vision.

How similar studies have gone: Previous studies have shown AI can enhance imaging analysis, but this project aims to further improve macular GCL measurement with ultrahigh-resolution data.

Where this research is happening

  • Oregon Health & Science University
    Portland, United States
    Active

Researchers

  • Principal investigator: Huang, David — Oregon Health & Science University
  • Study coordinator: Huang, David

Related research

Other NIH-funded projects on the same topics.

  • IOP and CSF Pressure in Glaucoma Risk

    This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11644421

  • Comparing tube positions in glaucoma implants to protect corneal cells

    This trial compares two tube placements for glaucoma drainage implants to see which better protects corneal cells and controls eye pressure in people with uncontrolled glaucoma.

    NIH research University of California, San Francisco · San Francisco, United States · NIH-11520347

  • Automated topographic test for glaucoma detection and progression

    A new automated method uses topographic structure-function mapping to help diagnose glaucoma earlier and track its progression in patients.

    NIH research Columbia University Health Sciences · New York, United States · NIH-11516608

  • Using AI on eye scans and genes to predict glaucoma risk

    This project uses artificial intelligence on eye scans, vision tests, and genetic information to find people most likely to develop or have worsening glaucoma.

    NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11469603

  • AI-based glaucoma screening in community health centers

    A new, easy-to-use AI screening approach will be tested in federally funded health centers to help identify people at risk for glaucoma, especially in communities with higher risk.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11454104

  • Understanding how glaucoma genes control eye cell function

    A long-term research project will study how genetic factors affect eye cells in adults with glaucoma to uncover new ideas for protecting vision.

    NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11450761

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.