Improving imaging techniques for glaucoma detection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to enhance the diagnosis and monitoring of glaucoma by developing advanced imaging technologies, including high-resolution optical coherence tomography (OCT) and OCT angiography. It focuses on validating these technologies to improve early detection of glaucoma and simulate visual field results by combining structural and angiographic data. The study addresses the limitations of current diagnostic tests, which often fail to accurately identify glaucoma, especially in patients with normal intraocular pressure. By exploring the role of blood flow imaging, the research seeks to provide a more objective assessment of glaucoma progression.

Why it matters

Who can join: the full rules

Inclusion Criteria: Normal Subjects (both eyes must meet all criteria)

1. No history or evidence of retinal pathology or glaucoma
2. Normal Humphrey 24-2 VF: A mean defect (MD), corrected pattern standard deviation (CPSD) within 95% limits of normal reference, and glaucoma hemifield test (GHT) within normal limits (97%).
3. Intraocular pressure \< 21 mm Hg
4. Central corneal pachymetry \> 500 microns
5. No chronic ocular or systemic corticosteroid use
6. Open angle (gonioscopy must show 75% or more of the angle to be Grade 2 or more by Shaffer's grading system)
7. Normal appearing ONH and NFL: vertical and horizontal cup/disc ratio (CDR) ≤ 0.5 and intact neuroretinal rim without peripapillary hemorrhages, notches, localized pallor, or NFL defect
8. Symmetric ONH between left and right eyes: CDR difference \< 0.2 in both vertical and horizontal dimensions

Inclusion criteria: Glaucoma Group

1. ONH or NFL defect visible on slit-lamp biomicroscopy defined as one of following:

   1. diffuse or localized thinning of the rim
   2. disc (splinter) hemorrhage
   3. notch in the rim
   4. vertical cup/disc ratio greater than the fellow eye by \> 0.2
2. Presence or absence of VF defects as measured by Humphrey SITA 24-2 VF.

Exclusion Criteria: All Groups

1. Best-corrected visual acuity less than 20/40
2. Age \< 40 or \>85 years
3. Refractive error of \> +3.00 D or \< -7.00 D
4. Previous intraocular surgery except for uncomplicated keratorefractive surgery and cataract extraction with posterior chamber intraocular lens implantation
5. Diabetic retinopathy
6. Other diseases that may cause VF loss or optic disc abnormalities
7. Inability to clinically view or photograph the optic discs due to media opacity or poorly dilating pupil
8. Inability to perform reliably on automated VF testing
9. Life-threatening or debilitating illness making it unlikely patient could successfully complete the study.
10. Refusal of informed consent or of commitment to the full length of the study

Where it's running

• Oregon Health & Science University, Casey Eye Institute
  Portland, Oregon, United States Recruiting

Study contacts

• Principal investigator: Aiyin Chen, MD — Oregon Health and Science University
• Study coordinator: Chinmay Deshpande, M.Optom.
• Email: deshpanc@ohsu.edu
• Phone: 503-494-9628

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.