Iris biomechanics and sex differences in primary angle-closure glaucoma
Official title: The role of iris biomechanics and sex differences in primary angle-closure glaucoma
Funded at University of South Florida · NIH-11394784 · Data updated 2026-11-12
This project looks at how the eye’s iris biomechanics and sex differences may contribute to angle-closure glaucoma and how this could affect risk and progression.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 30, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $248,999 |
| NIH project number | 5R00EY035360-05 |
| Project ID | NIH-11394784 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are adults at risk for or with a history of primary angle-closure glaucoma, and healthy controls for comparison.
✕Less likely to help
People without access to eye care or those outside the study’s eligibility may not benefit.
What this research studies
The study focuses on how the stiffness and behavior of the iris during light-triggered pupil responses may relate to angle-closure glaucoma, which can threaten vision. Researchers will study iris biomechanics in people with PACG and compare them to those without the condition to understand potential mechanisms. The findings could help identify new risk factors beyond anatomy and inform future strategies to prevent vision loss from PACG.
Why it matters
Potential benefit: A better understanding of iris biomechanics could lead to earlier risk detection and new approaches to prevent vision loss in PACG.
How similar studies have gone: Prior work suggests iris stiffness differs in PACG patients, supporting the potential for meaningful insights from this approach.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Naghizadehsafa, Babak — University of South Florida
- Study coordinator: Naghizadehsafa, Babak
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.