Comparing NAD precursors to improve vision in glaucoma patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effects of different oral supplements of nicotinamide adenine dinucleotide (NAD) precursors on visual function in adults with primary open-angle glaucoma. Participants will be randomly assigned to receive one of four NAD precursors or a placebo for two weeks, with assessments of visual field sensitivity and plasma NAD+ metabolite profiles conducted before and after treatment. The study aims to determine if any of the NAD precursors lead to significant improvements in visual function compared to placebo. Additionally, secondary objectives include measuring nerve fiber layer thickness and analyzing correlations between NAD+ metabolite levels and visual improvements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* glaucoma patients
* age ≥ 18 years
* best corrected VA ≥20/40
* IOP \<21 mmHg
* visual field mean deviation better than -24 dB on standard automated perimetry 24-2 SITA standard

Exclusion Criteria:

* pathological myopia
* diseases that may cause visual field loss or optic disc abnormalities other than glaucoma
* inability to perform reliable visual field
* suboptimal quality of OCT images
* diabetic retinopathy/maculopathy
* history of abnormal liver function within 12 months
* known allergy to NAD precursor supplement(s)
* pregnancy or lactation
* use of NAD precursor supplements 14 days prior to baseline.

Where it's running

• HKU Eye Centre
  Wong Chuk Hang, Hong Kong Recruiting

Study contacts

• Principal investigator: Christopher Kai-shun LEUNG, MD — The University of Hong Kong
• Study coordinator: Christopher Kai-shun LEUNG, MD
• Email: cleung21@hku.hk
• Phone: (852)3910-2673

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.