Diagnostic Innovations in Glaucoma for High Myopia
Official title: Diagnostic Innovations in Glaucoma Study (DIGS): Glaucoma and High Myopia
Funded at University of California, San Diego · NIH-11397407 · Data updated 2026-11-12
A study to improve early detection of open-angle glaucoma in people with high myopia using advanced eye imaging.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | March 1, 2017 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $661,404 |
| NIH project number | 5R01EY027510-10 |
| Project ID | NIH-11397407 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with high myopia who are at risk for open-angle glaucoma and are under eye care with access to OCT imaging.
✕Less likely to help
People without high myopia or those not at risk for glaucoma may not benefit from this study.
What this research studies
If you have high myopia, you may be at higher risk for glaucoma, and this project aims to make it easier to spot changes early with 3D imaging from eye scans. Researchers will look at optic nerve head structures in detail to tell apart normal aging from disease progression, using OCT scans. The goal is to develop patient-centered methods that clinicians can use to monitor high-risk eyes more accurately over time.
Why it matters
Potential benefit: If successful, this work could lead to earlier, more reliable glaucoma detection for people with high myopia, helping prevent vision loss.
How similar studies have gone: Previous glaucoma imaging studies show promise in improving detection, but this project focuses on high myopia specifically and developing practical 3D imaging parameters.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Zangwill, Linda M — University of California, San Diego
- Study coordinator: Zangwill, Linda M
Related research
Other NIH-funded projects on the same topics.
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Understanding how myopia and glaucoma are connected through eye mechanics
This study looks at how eye growth in myopia may influence glaucoma risk and what markers could identify it early.
-
How nearsightedness may raise glaucoma risk in retinal cells and vessels
A clinician-scientist is studying how myopia changes eye cells and blood vessels to understand why nearsighted people are more at risk for glaucoma.
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Detecting glaucoma in people with high nearsightedness (high myopia)
This project uses new three-dimensional eye imaging and analysis to find glaucoma earlier in people with high myopia.
-
How myopia affects eye cells and its link to glaucoma risk
This study is looking at how being nearsighted might affect the cells and blood vessels in your eyes, which could increase the chance of getting glaucoma, and it's for anyone interested in understanding how myopia can lead to changes in eye health.
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Exploring the link between myopia and glaucoma through cellular mechanisms
This study is looking at how having myopia (nearsightedness) might raise the chances of getting glaucoma, a serious eye disease, and it aims to find ways to help protect your vision by tracking changes in your eyes over time.
-
IOP and CSF Pressure in Glaucoma Risk
This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.