Effect of expiratory time constant (RCexp) on lung ventilation and blood flow in ventilated ARDS patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational physiology study enrolling adult ARDS patients within 72 hours of starting mechanical ventilation. Investigators will measure each patient’s expiratory time constant (RCexp) and use bedside monitoring, including electrical impedance tomography, to map regional ventilation and perfusion during routine ventilator care. Data will compare ventilation and perfusion distribution across different RCexp values and ventilator settings to identify patterns of V/Q matching. Patients with contraindications to the monitoring techniques or conditions like pneumothorax or ECMO are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

adult patients with ARDS receiving mechanical ventilation no more than 72 hours

Exclusion Criteria:

1. age \<18 years old
2. patient undergoing legal protection
3. contra-indications to EIT (e. g. severe chest trauma or wounds)
4. pneumothorax
5. patient undergoing ECMO
6. pregnancy

Where it's running

• Zhongda Hospital, School of Medicine, Southeast University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: yuan xue yan, MD
• Email: 18826401594@163.com
• Phone: +86-15901599659

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Observing physiological changes in ARDS patients in the prone position

  This study looks at how lying on the stomach affects breathing and oxygen levels in patients with Acute Respiratory Distress Syndrome to see if it can help improve their recovery.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT06586736

• Understanding reverse trigger in patients on mechanical ventilation

  This study looks at how often patients with severe lung problems on mechanical ventilation experience a condition called reverse trigger, to see how it affects their treatment and recovery.

  Recruiting Hospital Civil de Guadalajara · Guadalajara · NCT06148467

• Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS

  This study tests whether pulse wave EIT or saline bolus EIT can best show lung blood flow in ARDS patients on mechanical ventilation.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07908368

• Computed inspiratory muscle pressure to monitor inspiratory effort during pressure-targeted assist/control ventilation

  This study tests a noninvasive computed pressure method (cPmus) to see if it matches the traditional esophageal pressure method for measuring inspiratory effort in adults on pressure-targeted ventilation with spontaneous breathing.

  Recruiting Capital Medical University · Beijing · NCT07886918

• Noninvasive estimate of inspiratory effort to monitor pressure support ventilation

  This study tests whether a noninvasive computed inspiratory muscle pressure (cPmus) can match the traditional esophageal pressure method for adults on pressure support ventilation.

  Recruiting Capital Medical University · Beijing · NCT07886892

• Driving pressure-guided individualized PEEP vs standard PEEP during upper abdominal surgery

  In this randomized trial, adults at higher risk of breathing problems after upper abdominal surgery will try a personalized PEEP level based on the lowest driving pressure and compare it to a fixed PEEP of 5 cmH2O to see if it lowers postoperative lung complications.

  Recruiting Hopital Charles Nicolle · Tunis · NCT07885124

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.