Examining complications from mechanical ventilation in cardiac arrest survivors
Official title: Study of Ventilator Associated Event During Intensive Care After Resuscitated Cardiac Arrest.
Run by Centre Hospitalier Sud Francilien · NCT06466980 · Data updated 2026-11-12
This study looks at the problems that can happen from using breathing machines in people who survive cardiac arrest to see how these issues affect their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Centre Hospitalier Sud Francilien Academic / other |
| Locations | 1 site (Corbeil-Essonnes) |
| Status | Recruiting |
| Started | June 27, 2024 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | March 14, 2025 |
| Trial ID | NCT06466980 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults who have been successfully resuscitated from cardiac arrest and require invasive mechanical ventilation for at least four days.
✕Probably not a fit
Patients who have opposed the use of their data or those who require life-sustaining therapies within 24 hours of admission may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to describe the incidence, characteristics, risk factors, and outcomes of complications acquired during mechanical ventilation, known as ventilator-associated events (VAEs), in patients admitted to the intensive care unit after successful resuscitation from cardiac arrest. The study utilizes the new CDC criteria for VAEs to provide a more objective measure of these complications, which are a significant concern for cardiac arrest survivors. By analyzing the data collected from these patients, the study seeks to enhance understanding of the impact of VAEs on morbidity and mortality in this vulnerable population.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients recovering from cardiac arrest, potentially reducing the incidence of complications associated with mechanical ventilation.
How similar studies have gone: Previous studies have shown a significant association between ventilator-associated events and increased morbidity and mortality, indicating that this approach has been validated in similar contexts.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult male or female * Non-pregnant female * Successfully resuscitated from cardiac arrest during primary care * Invasive mechanical ventilation initiated during resuscitation and continued for at least 4 days * No decision to limit life-sustaining therapies within 24 hours following admission to intensive care * No requirement of arteriovenous circulatory support during intensive care management Exclusion Criteria \- patients who opposed to the use of their data
Where it's running
-
Centre Hospitalier Sud Francilien
Corbeil-Essonnes, France Recruiting
Study contacts
- Study coordinator: Fabrice COOK, MD
- Email: fabrice.cook@chsf.fr
- Phone: 01 61 69 52 28
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS
This study tests whether pulse wave EIT or saline bolus EIT can best show lung blood flow in ARDS patients on mechanical ventilation.
-
Computed inspiratory muscle pressure to monitor inspiratory effort during pressure-targeted assist/control ventilation
This study tests a noninvasive computed pressure method (cPmus) to see if it matches the traditional esophageal pressure method for measuring inspiratory effort in adults on pressure-targeted ventilation with spontaneous breathing.
-
Noninvasive estimate of inspiratory effort to monitor pressure support ventilation
This study tests whether a noninvasive computed inspiratory muscle pressure (cPmus) can match the traditional esophageal pressure method for adults on pressure support ventilation.
-
Driving pressure-guided individualized PEEP vs standard PEEP during upper abdominal surgery
In this randomized trial, adults at higher risk of breathing problems after upper abdominal surgery will try a personalized PEEP level based on the lowest driving pressure and compare it to a fixed PEEP of 5 cmH2O to see if it lowers postoperative lung complications.
-
Inspiratory Effort and Dyspnea During Assisted Mechanical Ventilation in Critically Ill Adults
This study tests how different patient breathing efforts relate to breathlessness in adults on assisted mechanical ventilation.
-
FCV vs VC—Obese Adults Undergoing Laparoscopic Surgery
In obese adults having laparoscopic surgery, researchers will see if flow-controlled ventilation (FCV) works better than volume-controlled ventilation with autoflow (VC-AF) at keeping airway pressures and lung energy lower.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.