Understanding how mechanical ventilation harms the lungs
Dissecting the molecular mechanisms of lung injury during mechanical ventilation
This study is looking at how the machines that help people breathe when they have serious lung problems can sometimes cause more harm, and it aims to find out how this happens so that we can make breathing treatments safer for patients with acute respiratory distress syndrome (ARDS).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11014415 on NIH RePORTER |
What this research studies
This research investigates the harmful effects of mechanical ventilation on patients with acute respiratory distress syndrome (ARDS). It focuses on how mechanical forces during ventilation can cause additional lung injury, known as ventilator-induced lung injury (VILI). The study aims to uncover the molecular mechanisms behind this injury, particularly the role of a protein complex called mTORC1, which may be a potential target for new treatments. By exploring these mechanisms, the research seeks to improve care for patients undergoing mechanical ventilation.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute respiratory distress syndrome (ARDS) who require mechanical ventilation.
Not a fit: Patients with mild respiratory issues that do not require mechanical ventilation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent lung injury in patients receiving mechanical ventilation.
How similar studies have performed: Previous research has shown that targeting molecular pathways like mTORC1 can be effective in reducing lung injury, suggesting a promising avenue for this study.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Englert, Joshua a — Ohio State University
- Study coordinator: Englert, Joshua a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.