Ventilation settings and acid-base balance after cardiac arrest or cardiogenic shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational analysis will retrospectively examine 100 adult patients admitted to a cardiac care unit, half after cardiac arrest and half with cardiogenic shock, who required mechanical ventilation. It will describe how often acid-base disorders occur and characterize their features. The study will compare clinicians’ initial ventilator settings with recommendations from the VentilO decision-support algorithm and assess potential effects on first blood gas results after admission. Data are drawn from the Laval University system at the Université Laval affiliated center in Québec, focusing on records available within four hours of admission. The results may inform how algorithm-guided ventilation could influence early management in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult (Age \>=18 years old)
* Under mechanical ventilation with endotracheal tube for :

post cardiac arrest or cardiogenic shock

\- Bood gases result availability up to 4 hours after coronary unit admission

Exclusion Criteria:

* Lack of patient anthropometric data (height and weight) available in the patient record
* No information in the record regarding the data on the humidification systems used at the time of the first blood gas test upon admission to the coronary care unit.
* Patient stabilzed in other hospital before coronary unit admission or adjustment of respiratory parameters after a blood gas test.

Where it's running

• Insitut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval
  Québec, Quebec, Canada Recruiting

Study contacts

• Study coordinator: Francois Lellouche
• Email: francois.lellouche@criucpq.ulaval.ca
• Phone: 1-418-656-8711

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Compare two ventilator modes in adults with cardiac ICU needs and invasive ventilation

  This pilot tests whether volume-controlled versus pressure-controlled ventilation can be safely used in adults with heart disease and respiratory failure who need invasive ventilation.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07656259

• On-scene extracorporeal CPR (ECPR) in Ostrava

  This tests doing ECMO (ECPR) at the scene for people ≤70 with witnessed out-of-hospital cardiac arrest who received bystander CPR to see if starting ECMO faster helps them survive with good brain function.

  Recruiting at 2 sites University Hospital Ostrava · Ostrava, Moravian-Silesian Region and 1 other locations · NCT07374289

• Smartphone-based EEG to detect hidden awareness in ICU patients with brain injuries

  Researchers will test a smartphone-enabled EEG to see if it can reveal Cognitive Motor Dissociation in ICU patients who can’t show commands at bedside.

  Recruiting Columbia University · Miami, Florida and 8 other locations · NCT07917728

• Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS

  This study tests whether pulse wave EIT or saline bolus EIT can best show lung blood flow in ARDS patients on mechanical ventilation.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07908368

• Physiology-guided Epinephrine Dosing in Pediatric Cardiac Arrest

  This observational study looks at how a child’s body responds to epinephrine during in-hospital cardiac arrests to see if dosing can be guided by physiology.

  Recruiting at 22 sites Children's Hospital of Philadelphia · Orange, California and 21 other locations · NCT07890610

• Computed inspiratory muscle pressure to monitor inspiratory effort during pressure-targeted assist/control ventilation

  This study tests a noninvasive computed pressure method (cPmus) to see if it matches the traditional esophageal pressure method for measuring inspiratory effort in adults on pressure-targeted ventilation with spontaneous breathing.

  Recruiting Capital Medical University · Beijing · NCT07886918

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.