Recruitment maneuver after suction to restore lung volume in ventilated ICU patients
Impact of a Recruitment Maneuver After Closed Endotracheal Suctioning on End-expiratory Lung Volume in Mechanically Ventilated ICU Patients Assessed by Electrical Impedance Tomography
This trial will test whether briefly raising airway pressure right after endotracheal suctioning helps reopen lungs and restore lung volume in adults on mechanical ventilation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 32 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer Academic / other |
| Locations | 1 site (Toulon, VAR) |
| Trial ID | NCT07358039 on ClinicalTrials.gov |
What this trial studies
This is a prospective, randomized, open-label, single-center crossover trial in intubated ICU patients. Each participant undergoes two interventions in random order: closed-circuit endotracheal suctioning alone versus suctioning immediately followed by a recruitment maneuver (30 cmH₂O for 30 seconds) with unchanged PEEP, separated by a 15-minute washout. Lung aeration and end-expiratory lung volume are measured with electrical impedance tomography, and functional residual capacity, respiratory compliance, and PaO₂/FiO₂ are recorded before and 15 minutes after each intervention. The design tests short-term physiological effects of the recruitment maneuver on post-suction derecruitment.
Who should consider this trial
Good fit: Adults (≥18) who are intubated and mechanically ventilated in the ICU, under neuromuscular blockade, covered by national health insurance, and with consent from a legally authorized representative are the intended participants.
Not a fit: Patients with contraindications to recruitment maneuvers (for example emphysema, undrained pneumothorax, or hemodynamic instability), those with implanted electrical devices preventing EIT, pregnant or breastfeeding women, and patients requiring prone ARDS management are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If positive, the intervention could reduce suction-related lung collapse and transient oxygenation loss in ventilated patients.
How similar studies have performed: Previous small physiological studies have shown mixed and limited results on recruitment after suctioning, and data in adult ICU populations remain sparse and conflicting.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged ≥18 years * Covered by national health insurance * Admitted to the intensive care unit * Intubated and mechanically ventilated * Neuromuscular blockade at inclusion * Written informed consent obtained from a legally authorized representative or next of kin Exclusion Criteria: * Contraindication to electrical impedance tomography (e.g. pacemaker, implantable cardioverter-defibrillator, or implanted electrical stimulation device) * Contraindication to recruitment maneuvers (e.g. emphysema, undrained pneumothorax, hemodynamic instability) * Refractory intracranial hypertension * Acute respiratory distress syndrome requiring prone positioning * Pregnant or breastfeeding women * Patients deprived of liberty or under legal protection * Any condition judged by the investigator to interfere with study evaluation
Where this trial is running
Toulon, VAR
- Hôpital National d'Instruction des Armées Sainte-Anne — Toulon, Var, France (Recruiting)
Study contacts
- Principal investigator: Cyril PERNOD, MD — Hôpital National d'Instruction des Armées (HNIA) Sainte-Anne, Toulon
- Study coordinator: Asmaa JOBIC, Ph.D
- Email: asmaa.jobic@ch-toulon.fr
- Phone: 04 83 77 20 61
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.