Recruitment maneuver after suction to restore lung volume in ventilated ICU patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized, open-label, single-center crossover trial in intubated ICU patients. Each participant undergoes two interventions in random order: closed-circuit endotracheal suctioning alone versus suctioning immediately followed by a recruitment maneuver (30 cmH₂O for 30 seconds) with unchanged PEEP, separated by a 15-minute washout. Lung aeration and end-expiratory lung volume are measured with electrical impedance tomography, and functional residual capacity, respiratory compliance, and PaO₂/FiO₂ are recorded before and 15 minutes after each intervention. The design tests short-term physiological effects of the recruitment maneuver on post-suction derecruitment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged ≥18 years
* Covered by national health insurance
* Admitted to the intensive care unit
* Intubated and mechanically ventilated
* Neuromuscular blockade at inclusion
* Written informed consent obtained from a legally authorized representative or next of kin

Exclusion Criteria:

* Contraindication to electrical impedance tomography (e.g. pacemaker, implantable cardioverter-defibrillator, or implanted electrical stimulation device)
* Contraindication to recruitment maneuvers (e.g. emphysema, undrained pneumothorax, hemodynamic instability)
* Refractory intracranial hypertension
* Acute respiratory distress syndrome requiring prone positioning
* Pregnant or breastfeeding women
* Patients deprived of liberty or under legal protection
* Any condition judged by the investigator to interfere with study evaluation

Where it's running

• Hôpital National d'Instruction des Armées Sainte-Anne
  Toulon, Var, France Recruiting

Study contacts

• Principal investigator: Cyril PERNOD, MD — Hôpital National d'Instruction des Armées (HNIA) Sainte-Anne, Toulon
• Study coordinator: Asmaa JOBIC, Ph.D
• Email: asmaa.jobic@ch-toulon.fr
• Phone: 04 83 77 20 61

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.