Predicting extubation failure in ICU patients using a physiotherapy assessment
Official title: Use of a Physiotherapy Assessment to Predict Extubation Failure in Mechanically Ventilated Patients: the EPIC Assessment
Run by Assistance Publique - Hôpitaux de Paris · NCT06450678 · Data updated 2026-11-12
This study is trying to see if a physiotherapy assessment can help predict which ICU patients on a ventilator might struggle after being taken off the machine.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 330 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | April 15, 2024 |
| Main results expected | April 2027 |
| Study ends | October 2027 |
| Registry record updated | March 27, 2026 |
| Trial ID | NCT06450678 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who have been on invasive mechanical ventilation for more than 48 hours and have passed a spontaneous ventilation test.
✕Probably not a fit
Patients who are tracheostomized, have severe psychiatric or cognitive disorders, or are under therapeutic restriction will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify predictive factors for extubation failure in mechanically ventilated patients in the ICU. Adult patients who have been on invasive mechanical ventilation for over 48 hours will undergo a spontaneous ventilation test, followed by an EPIC Assessment conducted by physiotherapists. The study will collect data on patient characteristics and known risk factors for extubation failure to enhance prediction accuracy. The goal is to improve decision-making regarding extubation and reduce associated complications.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the rates of extubation failure and its associated complications in ICU patients.
How similar studies have gone: While several studies have explored predictive criteria for extubation failure, this specific combined assessment approach is novel and has not been widely tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient 18 years of age or older * Admitted to intensive care and placed on invasive mechanical ventilation for more than 48 hours * Having passed a T-Tube spontaneous ventilation test \< 24h Exclusion Criteria: * Tracheostomized patient * Severe psychiatric pathology or cognitive disorders * Uncooperative patient * Patient under therapeutic restriction (terminal extubation) * Patient who has already participated in research * Patient or close relative (if patient not able) opposed to research * No relative if patient unable to receive information
Where it's running
-
Bichat - Claude Bernard Hospital
Paris, France Recruiting
Study contacts
- Principal investigator: Antoine SHENOUDA — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Antoine SHENOUDA, Physiotherapist
- Email: antoine.shenouda@aphp.fr
- Phone: 06 52 94 89 74
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.