Brain monitoring during ventilator therapy in critically ill patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center study will observe brain electrical activity and cerebral blood flow during clinically indicated recruitment maneuvers and PEEP changes in neurocritical care patients. Multimodal monitoring will include EEG, transcranial Doppler, invasive blood pressure, end-tidal CO2, and standard clinical data. The goal is to understand how ventilator settings influence brain perfusion, cerebral oxygenation, and neurovascular coupling. Findings may clarify brain-lung interactions during critical care ventilation and inform safer ventilation strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years.
* Admission to the neurocritical care unit with acute brain injury requiring intensive care management.
* Receiving invasive mechanical ventilation.
* Undergoing clinically indicated recruitment maneuvers and positive end-expiratory pressure (PEEP) adjustments.
* Availability of an adequate temporal acoustic window for transcranial Doppler monitoring.
* Written informed consent obtained from the participant or a legally authorized representative.

Exclusion Criteria:

* Pregnancy.
* Hemodynamic instability precluding recruitment maneuvers or PEEP adjustments.
* Severe cardiac dysfunction judged by the treating physician to contraindicate study procedures.
* Inability to obtain adequate transcranial Doppler signals.
* Conditions preventing EEG monitoring, including extensive scalp injury or dressings that preclude electrode placement.
* Withdrawal of informed consent.

Where it's running

• Shengli Oilfield Central Hospital
  Dongying, Shandong, China Recruiting

Study contacts

• Study coordinator: Min Xu
• Email: xuminicu@163.com
• Phone: +8613864708968

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.