Understanding factors related to weaning failure in critically ill patients on mechanical ventilation
Official title: Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients: A Retrospective Study
Run by Hospital Italiano de Buenos Aires · NCT06683781 · Data updated 2026-11-12
This study looks at why some critically ill patients on mechanical ventilation have trouble being taken off the ventilator, especially during their ICU stay.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 1077 (estimated) |
| Sponsor | Hospital Italiano de Buenos Aires Academic / other |
| Locations | 1 site (Buenos Aires) |
| Status | Recruiting |
| Started | December 1, 2024 |
| Main results expected | October 1, 2025 |
| Study ends | August 1, 2026 |
| Registry record updated | March 17, 2025 |
| Trial ID | NCT06683781 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are critically ill patients over 18 years old who have been on mechanical ventilation for at least 48 hours and have undergone extubation and spontaneous breathing trials.
✕Probably not a fit
Patients who do not have adequate or continuous monitoring during the weaning process or have inconsistent mechanical ventilation records may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the ventilatory settings and monitoring variables that are associated with weaning failure in critically ill patients who have been on mechanical ventilation. It focuses on patients who have undergone at least one extubation and one spontaneous breathing trial during their ICU stay. The study aims to identify the rates of weaning failure, particularly in the context of COVID-19, and to analyze the factors contributing to both successful and unsuccessful weaning attempts. By collecting and analyzing data from patients in the ICU, the study seeks to improve understanding of the weaning process and its challenges.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for weaning patients off mechanical ventilation, enhancing recovery outcomes in critically ill patients.
How similar studies have gone: Other studies have indicated varying success rates in weaning from mechanical ventilation, suggesting that while this approach is not entirely novel, it addresses a significant clinical challenge.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Over 18 years * MV for at least 48 hours, regardless of the cause of onset * Undergone at least one extubation, regardless of the outcome * At least one spontaneous breathing trial (SBT) during their ICU stay, regardless of the outcome Exclusion Criteria: * MV records containing incorrect or inconsistent data * did not have adequate or continuous monitoring during the weaning process
Where it's running
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Hospital Italiano de Buenos Aires
Buenos Aires, Argentina Recruiting
Study contacts
- Study coordinator: Emilio M Steinberg, RT
- Email: emilio.steinberg@hiba.org.ar
- Phone: +54 11 4959-0200
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Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.