Understanding factors related to weaning failure in critically ill patients on mechanical ventilation

Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients: A Retrospective Study

This study looks at why some critically ill patients on mechanical ventilation have trouble being taken off the ventilator, especially during their ICU stay.

Quick facts

• Study type: Observational
• Enrollment: 1077 (estimated)
• Ages: 18 Years to 100 Years
• Sex: All
• Sponsor: Hospital Italiano de Buenos Aires (Academic / other)
• Locations: 1 site (Buenos Aires)
• Trial ID: NCT06683781 on ClinicalTrials.gov

What this trial studies

This observational study investigates the ventilatory settings and monitoring variables that are associated with weaning failure in critically ill patients who have been on mechanical ventilation. It focuses on patients who have undergone at least one extubation and one spontaneous breathing trial during their ICU stay. The study aims to identify the rates of weaning failure, particularly in the context of COVID-19, and to analyze the factors contributing to both successful and unsuccessful weaning attempts. By collecting and analyzing data from patients in the ICU, the study seeks to improve understanding of the weaning process and its challenges.

Who should consider this trial

Good fit: Ideal candidates for this study are critically ill patients over 18 years old who have been on mechanical ventilation for at least 48 hours and have undergone extubation and spontaneous breathing trials.

Not a fit: Patients who do not have adequate or continuous monitoring during the weaning process or have inconsistent mechanical ventilation records may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved strategies for weaning patients off mechanical ventilation, enhancing recovery outcomes in critically ill patients.

How similar studies have performed: Other studies have indicated varying success rates in weaning from mechanical ventilation, suggesting that while this approach is not entirely novel, it addresses a significant clinical challenge.

Eligibility criteria

Inclusion Criteria:

* Over 18 years
* MV for at least 48 hours, regardless of the cause of onset
* Undergone at least one extubation, regardless of the outcome
* At least one spontaneous breathing trial (SBT) during their ICU stay, regardless of the outcome

Exclusion Criteria:

* MV records containing incorrect or inconsistent data
* did not have adequate or continuous monitoring during the weaning process

Where this trial is running

Buenos Aires

• Hospital Italiano de Buenos Aires — Buenos Aires, Argentina (Recruiting)

Study contacts

• Study coordinator: Emilio M Steinberg, RT

Conditions Mechanical Ventilation; Weaning Failure; Weaning Failure of Mechanical Ventilation; Intensive Care Unit ICU; weaning failure; mechanical ventilation