Using Remimazolam for Sedation in Patients After Heart Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of remimazolam besylate as a sedative for patients recovering from cardiac surgery who require mechanical ventilation. Participants aged 18 and older will be randomly assigned to receive either remimazolam or propofol for sedation, with the goal of achieving effective sedation while minimizing adverse effects and facilitating quicker extubation. The study aims to determine if remimazolam can provide a safer and more efficient sedation option compared to traditional sedatives.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. age ≥ 18 years ;
2. admitted to the intensive care unit after cardiac surgery with techanical ventilation；
3. expected to extubation within 48hours ；
4. participant has given informed consent

Exclusion Criteria:

1. pregnant or lactating women
2. known or suspected hypersensitivity to the study drug
3. history of impaired consciousness or psychiatric illness
4. severe bradycardia with a heart rate of \< 50 beats per minute
5. systolic blood pressure \< 90 mmHg with fluid resuscitation and vasopressor maintenance
6. atrioventricular block（II or III degree）, Left ventricular ejection fraction(LVEF) \<30%
7. participated in other clinical studies within 3 months

Where it's running

• First afflilated hospital of zhejiang university school of medicine
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Yu Wenqiao PhD
• Email: yuwenqiao1980@zju.edu.cn
• Phone: +86-18868787588

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.