Exploring a new ventilation method for patients on mechanical ventilation during surgery
Official title: Dead Space in Mechanical Ventilation With Constant Expiratory Flow
Run by University Hospital, Antwerp · NCT06024993 · Data updated 2026-11-12
This study is testing a new breathing method during surgery to see if it helps adults on mechanical ventilation clear carbon dioxide better than the standard method.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 13 (estimated) |
| Sponsor | University Hospital, Antwerp Academic / other |
| Locations | 1 site (Edegem, Antwerp) |
| Status | Recruiting |
| Started | July 22, 2024 |
| Main results expected | December 30, 2025 |
| Study ends | April 30, 2026 |
| Registry record updated | January 22, 2025 |
| Trial ID | NCT06024993 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18-70 undergoing elective surgery requiring general anesthesia and controlled mechanical ventilation.
✕Probably not a fit
Patients with conditions such as one lung ventilation, severe COPD, or those with increased intra-abdominal pressure may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of flow-controlled ventilation (FCV) compared to conventional volume-controlled ventilation (VCV) in patients undergoing elective surgery. The study focuses on how FCV, which maintains a constant expiratory flow, may improve carbon dioxide clearance and reduce dead space ventilation. Participants will be adults aged 18-70 who require controlled mechanical ventilation for at least 60 minutes during surgery. The trial aims to gather data on the potential advantages of FCV in a clinical setting.
Why it matters
Potential benefit: If successful, this study could lead to improved ventilation strategies that enhance patient outcomes during surgery.
How similar studies have gone: Previous studies have shown promising results with flow-controlled ventilation, indicating potential benefits over traditional methods, though this specific comparison is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults \[18-70\] yrs * General anaesthesia for elective surgery * Arterial line, central venous line and endotracheal tube as part of standard of care * Expected duration of controlled mechanical ventilation ≥ 60 minutes * Supine position (0±10°) Exclusion Criteria: * One lung ventilation * Known pregnancy * Increased intra-abdominal pressure (pneumoperitoneum or obesity (BMI \> 30kg/m2)) * COPD GOLD IV or home oxygen dependence * Cardiac pacemaker, implantable cardioverter-defibrillator (ICD) or thoracic neurostimulator * Skin lesions (e.g. injury, inflammation) at the level where the Electrical Impedance Tomography (EIT) band is to be applied * Clinical signs of raised intracranial pressure * Potential interference with the surgery due to the setup of the study instruments. * Patient refusal to participate
Where it's running
-
Antwerp University Hospital (UZA)
Edegem, Antwerp, Belgium Recruiting
Study contacts
- Principal investigator: Vera Saldien, M.D., Ph.D. — Antwerp University Hospital / University of Antwerp
- Study coordinator: Carine Smitz
- Email: carine.smitz@uza.be
- Phone: +32 3 821 49 30
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS
This study tests whether pulse wave EIT or saline bolus EIT can best show lung blood flow in ARDS patients on mechanical ventilation.
-
Computed inspiratory muscle pressure to monitor inspiratory effort during pressure-targeted assist/control ventilation
This study tests a noninvasive computed pressure method (cPmus) to see if it matches the traditional esophageal pressure method for measuring inspiratory effort in adults on pressure-targeted ventilation with spontaneous breathing.
-
Noninvasive estimate of inspiratory effort to monitor pressure support ventilation
This study tests whether a noninvasive computed inspiratory muscle pressure (cPmus) can match the traditional esophageal pressure method for adults on pressure support ventilation.
-
Driving pressure-guided individualized PEEP vs standard PEEP during upper abdominal surgery
In this randomized trial, adults at higher risk of breathing problems after upper abdominal surgery will try a personalized PEEP level based on the lowest driving pressure and compare it to a fixed PEEP of 5 cmH2O to see if it lowers postoperative lung complications.
-
Inspiratory Effort and Dyspnea During Assisted Mechanical Ventilation in Critically Ill Adults
This study tests how different patient breathing efforts relate to breathlessness in adults on assisted mechanical ventilation.
-
FCV vs VC—Obese Adults Undergoing Laparoscopic Surgery
In obese adults having laparoscopic surgery, researchers will see if flow-controlled ventilation (FCV) works better than volume-controlled ventilation with autoflow (VC-AF) at keeping airway pressures and lung energy lower.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.