Exploring a new ventilation method for patients on mechanical ventilation during surgery
Dead Space in Mechanical Ventilation With Constant Expiratory Flow
This study is testing a new breathing method during surgery to see if it helps adults on mechanical ventilation clear carbon dioxide better than the standard method.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 13 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | University Hospital, Antwerp Academic / other |
| Locations | 1 site (Edegem, Antwerp) |
| Trial ID | NCT06024993 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of flow-controlled ventilation (FCV) compared to conventional volume-controlled ventilation (VCV) in patients undergoing elective surgery. The study focuses on how FCV, which maintains a constant expiratory flow, may improve carbon dioxide clearance and reduce dead space ventilation. Participants will be adults aged 18-70 who require controlled mechanical ventilation for at least 60 minutes during surgery. The trial aims to gather data on the potential advantages of FCV in a clinical setting.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-70 undergoing elective surgery requiring general anesthesia and controlled mechanical ventilation.
Not a fit: Patients with conditions such as one lung ventilation, severe COPD, or those with increased intra-abdominal pressure may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved ventilation strategies that enhance patient outcomes during surgery.
How similar studies have performed: Previous studies have shown promising results with flow-controlled ventilation, indicating potential benefits over traditional methods, though this specific comparison is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults \[18-70\] yrs * General anaesthesia for elective surgery * Arterial line, central venous line and endotracheal tube as part of standard of care * Expected duration of controlled mechanical ventilation ≥ 60 minutes * Supine position (0±10°) Exclusion Criteria: * One lung ventilation * Known pregnancy * Increased intra-abdominal pressure (pneumoperitoneum or obesity (BMI \> 30kg/m2)) * COPD GOLD IV or home oxygen dependence * Cardiac pacemaker, implantable cardioverter-defibrillator (ICD) or thoracic neurostimulator * Skin lesions (e.g. injury, inflammation) at the level where the Electrical Impedance Tomography (EIT) band is to be applied * Clinical signs of raised intracranial pressure * Potential interference with the surgery due to the setup of the study instruments. * Patient refusal to participate
Where this trial is running
Edegem, Antwerp
- Antwerp University Hospital (UZA) — Edegem, Antwerp, Belgium (Recruiting)
Study contacts
- Principal investigator: Vera Saldien, M.D., Ph.D. — Antwerp University Hospital / University of Antwerp
- Study coordinator: Carine Smitz
- Email: carine.smitz@uza.be
- Phone: +32 3 821 49 30
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.