Titrating pressure support using the Flow Index in adults on mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, randomized pilot study compares FI-guided pressure support titration to conventional titration based on tidal volume and respiratory rate in adults expected to need invasive ventilation for more than 48 hours. The study primarily looks at safety and feasibility, including how often safety assessments fail or the trial is terminated early. It also explores whether FI-guided titration yields more respiratory muscle activity within the normal range, indicating adequate inspiratory effort. The trial uses two arms: FI-guided adjustments and conventional PSV adjustments, within an ICU setting. The focus is on adults without certain comorbidities or conditions that could affect respiratory mechanics.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (age ≥ 18 years) receiving pressure support ventilation (PSV)
* Expected duration of invasive mechanical ventilation \> 48 hours

Exclusion Criteria:

* Patients who have received PSV for \> 48 hours at the time of screening
* Neuromuscular disease, diaphragmatic dysfunction, or central nervous system disease affecting the respiratory center
* Incomplete lung or chest wall integrity (e.g., pneumothorax, tracheoesophageal fistula, rib fractures)
* Acute respiratory distress syndrome (ARDS) or chronic obstructive pulmonary disease (COPD)
* Body mass index (BMI) \> 35 kg/m²
* Pregnancy or lactation
* Participation in another interventional study or refusal to participate

Where it's running

• Capital Medical University Beijing Tiantan Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Yi-Min Zhou
• Email: acapoftea2021@163.com
• Phone: +8618518474093

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS

  This study tests whether pulse wave EIT or saline bolus EIT can best show lung blood flow in ARDS patients on mechanical ventilation.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07908368

• Computed inspiratory muscle pressure to monitor inspiratory effort during pressure-targeted assist/control ventilation

  This study tests a noninvasive computed pressure method (cPmus) to see if it matches the traditional esophageal pressure method for measuring inspiratory effort in adults on pressure-targeted ventilation with spontaneous breathing.

  Recruiting Capital Medical University · Beijing · NCT07886918

• Noninvasive estimate of inspiratory effort to monitor pressure support ventilation

  This study tests whether a noninvasive computed inspiratory muscle pressure (cPmus) can match the traditional esophageal pressure method for adults on pressure support ventilation.

  Recruiting Capital Medical University · Beijing · NCT07886892

• Driving pressure-guided individualized PEEP vs standard PEEP during upper abdominal surgery

  In this randomized trial, adults at higher risk of breathing problems after upper abdominal surgery will try a personalized PEEP level based on the lowest driving pressure and compare it to a fixed PEEP of 5 cmH2O to see if it lowers postoperative lung complications.

  Recruiting Hopital Charles Nicolle · Tunis · NCT07885124

• Inspiratory Effort and Dyspnea During Assisted Mechanical Ventilation in Critically Ill Adults

  This study tests how different patient breathing efforts relate to breathlessness in adults on assisted mechanical ventilation.

  Recruiting University of Crete · Heraklion · NCT07877350

• FCV vs VC—Obese Adults Undergoing Laparoscopic Surgery

  In obese adults having laparoscopic surgery, researchers will see if flow-controlled ventilation (FCV) works better than volume-controlled ventilation with autoflow (VC-AF) at keeping airway pressures and lung energy lower.

  Recruiting Kocaeli University · Kocaeli, Izmit · NCT07875530

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.