Understanding how mechanical ventilation causes kidney injury
Mechanisms of acute kidney injury due to mechanical ventilation
This study is looking at how using a breathing machine for very sick patients might affect their kidneys and cause problems, with the goal of finding ways to protect kidney health in those who need this treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Medical Research Fdn/san Diego NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-11084459 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which mechanical ventilation, a critical treatment for severely ill patients, can lead to acute kidney injury (AKI). The study aims to identify the physiological changes in kidney function that occur during mechanical ventilation, which may contribute to increased risks of kidney damage. By using advanced techniques to assess kidney function, the researchers hope to uncover new pathways that could be targeted for future therapies to prevent or treat AKI. This work is essential for improving outcomes for patients who require mechanical ventilation.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill patients who require mechanical ventilation and are at risk for acute kidney injury.
Not a fit: Patients who are not critically ill or do not require mechanical ventilation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of kidney injury in patients undergoing mechanical ventilation.
How similar studies have performed: Previous research has shown that understanding the mechanisms of kidney injury can lead to improved treatment strategies, suggesting that this approach has the potential for success.
Where this research is happening
San Diego, United States
- Veterans Medical Research Fdn/san Diego — San Diego, United States (Active)
Researchers
- Principal investigator: Hepokoski, Mark Lawrence — Veterans Medical Research Fdn/san Diego
- Study coordinator: Hepokoski, Mark Lawrence
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.