Predicting who will need reintubation after a successful breathing trial
Official title: The First Affiliated Hospital of Chongqing Medical University
Run by Chongqing Medical University · NCT05069441 · Data updated 2026-11-12
This project will try to combine simple bedside signs to predict which mechanically ventilated adults who pass a spontaneous breathing trial are likely to need reintubation or die within a week.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2604 (estimated) |
| Sponsor | Chongqing Medical University Academic / other |
| Locations | 1 site (Chongqing) |
| Status | Recruiting |
| Started | October 15, 2021 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | March 23, 2026 |
| Trial ID | NCT05069441 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18 years or older) who are mechanically ventilated, have an oral or nasal endotracheal tube, and have successfully completed a spontaneous breathing trial and are prepared for extubation are eligible.
✕Probably not a fit
Patients extubated without a spontaneous breathing trial, patients reintubated because of secondary surgery, and those with a tracheotomy are unlikely to benefit from this prediction scale.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational effort to collect routine bedside and laboratory variables from mechanically ventilated adults who have successfully completed a spontaneous breathing trial and are planned for extubation. Collected data include vital signs, arterial blood gases, cough strength, cuff-leak test results, and use of noninvasive ventilation, among others, with follow-up to 28 days postextubation or hospital discharge. Investigators will analyze predictors of extubation failure (reintubation or death within 7 days), then combine easily obtained variables to develop and validate a bedside risk scale and identify cutoff values for low, moderate, and high risk. The study aims to produce a simple tool usable at the bedside to stratify postextubation risk.
Why it matters
Potential benefit: If successful, the scale could help clinicians identify low, moderate, or high risk patients at the bedside and guide decisions to prevent reintubation and related complications.
How similar studies have gone: Prior research has identified individual predictors such as rapid shallow breathing index, cough strength, and cuff-leak tests, but combining these into a validated, widely accepted bedside scale remains novel and not yet established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Prepared for extubation through spontaneous breathing trial;Oral or nasal endotracheal intubation; be at least 18 years old Exclusion Criteria: * Extubation without a spontaneous breathing trial ;Reintubation due to secondary surgery; Tracheotomy
Where it's running
-
The First Affiliated Hospital of Chongqing Medical University
Chongqing, China Recruiting
Study contacts
- Principal investigator: Jun Duan — First Affiliated Hospital of Chongqing Medical University
- Study coordinator: Jun Duan, Dr
- Email: duanjun412589@163.com
- Phone: 89012017
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.